NATURAL PERMEATION ENHANCER FOR TRANSDERMAL DRUG DELIVERY SYSTEM AND PERMEATION EVALUATION: A REVIEW

Asha Das; Abdul Baquee Ahmed

doi:10.22159/ajpcr.2017.v10i9.19389

Authors

Asha Das Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati, Assam, India.
Abdul Baquee Ahmed Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati, Assam, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i9.19389

Keywords:

Transdermal drug delivery system, Permeation enhancer, Transdermal barrier

Abstract

The transdermal drug delivery route is evolving as a potential route due to its advantages of bypassing the hepatic first pass metabolism, decreasedÂ side effects and gastrointestinal effects, improve patience compliance as it is a pain-free self-administration for patients, etc. The major setbackÂ appearing in this route is the difficulty of the drugs to penetrate through the skin as the stratum corneum (outermost layer of the skin) forms aÂ protective barrier for the underlying tissues from the outer environment. A transdermally delivered drug can only show its action when it can crossÂ the transdermal barrier to reach the systemic circulation and for helping on doing that the penetration enhancer are the agents which increase theÂ permeability of the skin which on return maintains the drug level in the blood. Permeation enhancers can be of a chemical type, natural type, andÂ physical type. The present review describes the natural permeation enhancers can be which be employed for transdermal permeation of drugs.

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Author Biography

Asha Das, Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati, Assam, India.

Deptt. Of Pharmaceutics

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