A STUDY OF DRUG RELATED PROBLEM IN UROLOGIC PATIENTS: A COHORT PROSPECTIVE STUDY
DOI:
https://doi.org/10.22159/ajpcr.2017.v10s2.19472Keywords:
Drug therapy problems, Clinical pharmacist, Drug therapy, Drug interactions, Adverse drug reactionsAbstract
Objective:Drug therapy problems (DRPs) are the clinical domain of the pharmaceutical care practitioner. The purpose of identifying drug therapy problems is to help patients on achieving their goals of therapy and realizing the best possible outcomes from drug therapy. The purpose of this study was to determine the number of DRPs and to classifyDRPs that occurred in post-operative patients from urology surgery ward.
Methods:A 3-month prospective study was conducted by considering62 hospitalized post-operative patients from urology surgery ward at the Teaching Hospital in Surabaya, East Java, Indonesia. Clinical pharmacists were involved in medical rounds to identify DRPs.
Results:From 37 patients, 81 DRPs were identified in this study. About 20 patients were considered to have more than one DRP. The most common identified DRPs were over-dosage (38%), drug use without indication (20%),improper drug (11%), drug interaction (10%), untreated indication(9%), adverse drug reaction (7%), failure to receive drug (4%) and sub-therapeutic drugs (1%). The clinical pharmacists were involved in doing dose adjustment, monitoring, evaluating drug discontinuation, doing drug substitution and, additional therapy, counseling to patients, increasing dose and referring to prescriber.
Conclusion:The most identified DRPs were over-dosage, drug use without indication and improper drug. Clinical pharmacist's intervention were required toidentify, prevent, resolve DRPs and assist patient on achieving their goals of therapy and improving their quality of life.
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References
Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm 1990;47(3):533-43.
Cipolle R, Strand L, Peter M. Pharmaceutical Care. 2nd ed. New York, NY: Mc Graw-Hill; 1998.
Ernst F, Grizzile A. Drug Related morbidity and mortality: Updating the cost-of-illness model. J Am Pharm Assoc 2001;41:192-9.
Adusumilli P, Adepu R. Drug related problems: An over view of various classification systems. Asian J Pharm Clin Res 2014;7 Suppl 4:7-10.
Cockcroft D, Gault M. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16 Suppl 1:31-41.
Vijayalakshmi S, George R, James E. Clinical pharmacist’s interventions on drug related problems in a tertiary care hospital. Int J Pharm Pharm Sci 2015;7 Suppl 6:401-4.
Prasanna D, Kumar BS, Venkataraman R, Fuloria PC. Assessment of clinical pharmacist intervention in tertiary care teaching hospital of Southern India. Asian J Pharm Clin Res 2013;6 Suppl 2:258-61.
Castelino R, Sathvik B, Parthasarathi G, Gurudev K, Shetty M, Narahari M. Prevalence of medication-related problems among patients with renal compromise in an Indian hospital. J Clin Pharm Ther 2011;36 Suppl 4:481-7.
Samoy L, Zed P, Wilbur K, Balen R, Abu-Laban R, Roberts M. Drug-related hospitalizations in a tertiary care internal medicine service of a Canadian hospital: A prospective study. Pharmacotherapy 2006;26 Suppl 11:1578-86.
Munar M. Drug dosing adjustments in patients with chronic. Am Fam Physician 2007;75 Suppl 10:1487-96.
Alagiriswami B, Ramesh M, Parthasarathi G, Basavanagowdappa H. A study of clinical pharmacist initiated changes in drug therapy in a teaching hospital. Indian J Pharm Pract 2009;1 Suppl 2:36-45.
Ganachari M, Kumar BM, Shashikala C, Fibrin M. Assessment of drug therapy intervention by clinical pharmacist in tertiary care hospital. Indian J Pharm Pract 2009;38 Suppl 5:361-2.
Al-Hajje AH, Atoui F, Awada S, Rachidi S, Zein S, Salameh P. Drug-related problems identified by clinical pharmacist’s students and pharmacist’s interventions. Ann Pharm Fr 2012;70(3):169-76.
Ayalew MB, Megersa TN, Mengistu YT. Drug-related problems in medical wards of Tikur Anbessa specialized hospital, Ethiopia. J Res Pharm Pract 2015;4 Suppl 4:216-21.
Huri HZ, Wee HF. Drug related problems in Type 2 diabetes patients with hypertension: A cross-sectional retrospective study. BMC Endocr Disord 2013;13 Suppl 2:1-25.
Baxter IA, Davis M, Driver S, Garner R. In: Baxter K, editor. Stockley’s Drug Interactions. 9th ed. London: Pharmaceutical Press; 2010.
Nishio S, Watanabe H, Kosuge K, Uchida S, Hayashi H, Ohashi K. Interaction between amlodipine and simvastatin in patients with hypercholesterolemia and hypertension. Hypertens Res 2005;28 Suppl 3:223-7.
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