THE SPERMICIDE GELS FORMULATION FROM THE DURIAN'S (DuriozibethinusMurr.) CORTEX EXTRACT: THE DECOLOURIZATION AND SOLID DISPERSION

Nani Kartinah; Mia Fitriana; Anni Nurliani; Revani Hardian

doi:10.22159/ajpcr.2017.v10s2.19477

Authors

Nani Kartinah Department of Pharmacy, Faculty of Mathematics and Natural Science, Lambung Mangkurat University, South Borneo, Indonesia
Mia Fitriana Department of Pharmacy, Faculty of Mathematics and Natural Science, Lambung Mangkurat University, South Borneo, Indonesia
Anni Nurliani Department of Biology, Faculty of Mathematics and Natural Science, Lambung Mangkurat University, South Borneo, Indonesia.
Revani Hardian Department of Pharmacy, Faculty of Mathematics and Natural Science, Lambung Mangkurat University, South Borneo, Indonesia

DOI:

https://doi.org/10.22159/ajpcr.2017.v10s2.19477

Keywords:

Spermicide gels, Durio zibethinus, Decolorization, Solid dispersion

Abstract

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Â Objective: The efficacy of the Durio zibethinus cortex extract as spermicidal agent was investigated on mice sperms and human sperms. The intense color spoiled the final product appearance. The purpose of this study was to determine the effect of decolorization and the best formula for preparation the spermicide gel from D. zibethinus cortex extract.

Methods: The extract of the D. zibethinus cortex was prepared by two-step methods before made into the spermicide gels preparation. First, decolorization used activated carbon and second, the extract was formed into solid dispersion with variation of the polyethylene glycol (PEG) 6000 concentration were 2%, 4%, 6%, and 10%. The extract quality was investigated by total phenolic. The gel preparation was evaluated for pH value, viscosity, and spreadability.

Results: The decolorization reduced 23.25% of total phenolic. The variation of the PEG 6000 concentration increased the viscosity (p<0.05) but decreased pH value and the spreadability (p<0.05).

Conclusion: The decolorization increased final product appearance and formulation with 2% of PEG 6000 was found to be the best.

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References

Singh A, Pramod KS, Nitin K, Rupesh D, Shushank D. Review: Novel spermicidal agent. Pharm Chem 2010;2 Suppl 4:278-97.

Shah HC, Pratima T, Kamalinder KS. Review: Spermicidal agents. Drug Discov Ther 2008;2 Suppl 4:200-10.

Nurliani A, Nani K. Formulasi Sediaan Gel Spermisida Ekstrak Kulit Kayu Durian (Durio zibethinus Murr). AQ3 ???: FMIPA Universitas Lambung Mangkurat; 2015.

Marinova D, Ribarova F, Atanassova M. Total phenolics and total flavanoids in bulgarian fruits and vegetables. J Univ Chem.Technol Metall 2005;40 Suppl 3:255-60.

Chiou WL, Sidney R. Review: Pharmaceutical applications of solid dispersion systems. J Pharm Sci 1971;60 Suppl 9:1281-302.

AQ4 6. Lubis ES, Lely SL, Julia R. Pelembab kulit alami dari sari buah jeruk bali (Citrus maxima Burm. Osbeck). J Pharm Pharmacol 2012; 1 Suppl 2:104-11.

Kumesan YA, Paulina VY, Hamidah SS. Formulasi dan uji aktivitas gel antijerawat ekstrak umbi bakung (Crinum asiaticum L.) Terhadap bakteri Staphylococcus aureus secara in vitro. Pharmacon 2013;2 Suppl 2:18-26.

Stankovic M, Vesna S, Valentina M. Development of formulations for vaginal gel carrier in the pharmacy - A regulatory and quality aspect. Sci J Fac Med NiÅ¡ 2012;29 Suppl 1:23-30.

Arikumalasari J, Dewantara IG, Wijayanti NP. Optimasi HPMC sebagai gelling agent dalam formula gel ekstrak kulit buah manggis (Garciana mangostana L.). J Farmasi Udayana 2013;2 Suppl 3:145-52.

Narayana RC, Harish NM, Mohammed GA, Prabhu P, Amit KS, Subrahmanyam EV. Formulation and in vitro evaluation of in situ gels containing secnidazole for vaginitis. Yakugaku Zasshi 2009;129 Suppl 5:569-74.

Mappa T, Hosea JE, Novel K. Formulasi gel ekstrak daun sasaladahan (Peperomia pellucida L.) Dan uji efektivitasnya terhadap luka bakar pada kelinci (Oryctolagus cuniculus). Pharmacon 2013;2 Suppl 2:49 55.

Chee TL, Rozilawati AG, Fadzillah AA, Mohammad RS. Herbal extract decolourization device using activated carbon. J. Teknol 2013;61 Suppl 1:73-9.

Caqueret V, Stephane B, Benoit C, Henri F. Purification of sugar beet vinasse - Adsoption of polyphenolic and dark colored compounds on different commercial activated carbons. Bioresour Technol 2008;99 Suppl 13:5814-21.

Johansen A, Torben S. Effects of interactions between powder particle size and binder viscosity on agglomerate growth mechanism in a high shear mixer. Eur J Pharm Sci 2001;12 Suppl 3:297-309.

Choi HK, Lee M, Kim M, Kim C. Effect of additives on the physicochemical properties of liquid suppository bases. Int J Pharm 1999;190:13-9.

Garge A, Deepika A, Garg S, Singla AK. Spreading of Semisolid Formulation. USA: Pharmaceutical Technology; 2002.