DIURETIC ACTIVITY OF MATOA LEAVES EXTRACTS (Pometiapinnata) AND ITS INFLUENCE ON POTASSIUM AND SODIUM LEVELS

Authors

  • Ika Purwidyaningrum Department of School of Pharmacy, Bandung Institute of Technology, Indonesia
  • Elin Yulinah Sukandar Department of School of Pharmacy, Bandung Institute of Technology, Indonesia
  • Irda Fidrianny Department of School of Pharmacy, Bandung Institute of Technology, Indonesia

DOI:

https://doi.org/10.22159/ajpcr.2017.v10s2.19481

Keywords:

Matoa (Pometiapinnata), Diuretic, Urine volume, Potassium levels, Sodium levels

Abstract

Objective: The purpose of this study was to determine diuretic activity of matoa leaves (Pometiapinnata) extracts and fraction and its influence on potassium and sodium levels.

Methods: Matoa leaves were extracted by reflux method followed by evaporation using rotary evaporator. The subjects were male Wistar rats that were divided into 11 group furosemide (3.6 mg/kg bw), control group CMC 0.5%, matoa leaves extracts with doses of 50 mg/kg bw, 100 mg/kg bw, 150 mg/kg bw, matoa leaves aqueous fraction with dose of 10.94 mg/kg bw, 21.88 mg/kg bw, 32.82 mg/kg bw, matoa leaves ethyl acetate fraction with dose of 4.35 mg/kg bw, 8.71 mg/kg bw, 13.06 mg/kg bw. Rats were placed in metabolic cagesduring observation study. Urine volume was measured for 5 to 24 hours. Potassium and sodium levels in urine were determined by using Atomic Absorption Spectrophotometry.

Results: The effective dose of matoa leaves extract and fractions for diuretic activity was matoaleaves ethyl acetate fraction 8.71 mg/kg bw which could increase the excretion of sodium and potassium in the urine of the male Wistar rats.

Conclusion:Matoa leaves extract and fractions could increase the excretion of sodium and potassium in the urine of the male Wistar rats.

 

 

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References

Niranjan S, Alok DK, Soumya MK, Priyanka G, Susri MS. Diuretic activity of Achyranthes aspera leaves extract. Int Res J Pharm 2012;3(4):216-8.

Roa KN, Sunitha CH, Banji D, Sandhya S, Shwetha D, Krishna M. Diuretic activity on different extracts and formulation on aerial parts of Rumex vesicarius Linn. J Chem Pharm Res 2011;3(6):400-8.

Gunawan SG, editor. Pharmacology and Therapy. 5th ed. Jakarta: Medical Faculty Indonesia University; 2007. p. 305, 389, 403, 481-93.

Permadi A. Facilitate Medicinal Plants Urine. 1st ed. Jakarta: Penebar Swadaya; 2006. p. 3-17.

Vazir A, Cowie MR. The use of diuretics in acute hearth failure: Evidence base therapy? World J Cardiovasc Dis 2013;3(2):25-34.

Fransworth NR, Akerele O, Bingel AS, Soejarto DD, Guo ZG. Medicinal plants in therapy. Bull World Health Organ 1985;63(6):965-81.

Gilani AH, Rahman AU. Trends in ethnopharmocology. J Ethnopharmacol 2005;100(1-2):43-9.

Asif M, Jabeen Q, Atif M, Majid AM, Zaman MQ. Diuretic activity of Achyranthes aspera Lin. Crude aqueous extract in albino rats. Trop J Pharm Res 2014;13(12):2039-45.

Suedee A, Tewtrakul S, Panichayupakaranant P. Anti-HIV-1 integrase compound from Pometia pinnata leaves. Pharm Biol 2013;51(10):1256-61.

Gandjar IG, Rohman A. Pharmaceutical Chemistry Analysis. Yogyakarta: Pustaka Pelajar; 2009. p. 298-322.

Turner RA. Screening Methods in Pharmacology. Vol. 3. London: Academic Press; 1971.

Sa’roni S, Azirah YN. Diuretic effect of Desmodium triquentrum (L) DC (daun duduk) to animals. Res Dev Health Media 2006;16(3):19-23. 13. Jeffery GH, Bassett J, Mendham J, Denny RC. Vogel’s Textbook of Quantitative Chemical Analysis. 5th ed. London: Addison Wesley Longman Ltd.; 1989.

Guyton AC, Hall JE. Textbook of Medical Physiology. Medical Book. 9th ed. Jakarta: ECG; 1997. p. 397-415.

Melendez-Camargo ME, Contretas-Leon I, Silvia-Torres R. Diuretic effect of alkaloids fraction extract from Selaginella lephidhophylla (Hook et Grev.) Spring. Bol Latinoam Caribe Plantas Med Aromat 2014;13(1):92-9.

Nadila F. Antihypertensive potential of chayote fruit extract for hypertension treatment. Lampung university. Lampung J Majority 2014;3(7):34-8.

Robinson T. The Organic Constituents of Higher Plants. 6th ed. North Amherst: Cordus Press; 1991. p. 71, 161, 191.

Published

01-05-2017

How to Cite

Purwidyaningrum, I., E. Y. Sukandar, and I. Fidrianny. “DIURETIC ACTIVITY OF MATOA LEAVES EXTRACTS (Pometiapinnata) AND ITS INFLUENCE ON POTASSIUM AND SODIUM LEVELS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 14, May 2017, pp. 31-34, doi:10.22159/ajpcr.2017.v10s2.19481.

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