G-QUADRUPLEX LIGANDS AS STABILIZER TARGETING TELOMERASE ENZYME AS ANTI CANCER AGENTS

Authors

  • Hemalatha Cn Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.
  • Vijey Aanandhi M Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.
  • Vijey Aanandhi M Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i8.19797

Keywords:

Perylene derivatives, G-Quadruplex, Telomerase, Anticancer

Abstract

The human telomere stabilization with G-Quadruplex DNA tends to induce apoptosis. The molecular target of telomere cascade with a rigid molecular may show efficacious to treat cancer. The study of intercalation to human telomeric DNA with proposed ligand can be evaluated by the help of biophysical studies and biological studies. G-Quadruplex is one of the key epigenetic episodes of eukaryotes and prokaryotes, generally found in the telomeric end region, immunoglobulin switch recombination and the lagging strand of the DNA. These chemotherapeutic advances are not enough to maintain a life expectancy of cancer affected patients. A number of G-Quadruplex ligands such as acridine, perylene, and anthraquinones have been synthesized reported and evaluated them for the inhibitor activity. Therefore, translational research can pave the novel prospect to treat cancer in a fundamental way. In that connection, basic research showed G-Quadruplex phenomenon of DNA, which is having a great impact in this chemotherapy.

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Author Biography

Hemalatha Cn, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.


Professor and Head
Department of Pharmaceutical Chemistry and Analysis

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Published

01-08-2017

How to Cite

Cn, H., V. A. M, and V. A. M. “G-QUADRUPLEX LIGANDS AS STABILIZER TARGETING TELOMERASE ENZYME AS ANTI CANCER AGENTS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 8, Aug. 2017, pp. 50-53, doi:10.22159/ajpcr.2017.v10i8.19797.

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Section

Review Article(s)