HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF TERMINALIA CHEBULA FRUIT AGAINST ETHANOL INDUCED HEPATOTOXICITY IN RATS

Balakrishna V; Lakshmi T

doi:10.22159/ajpcr.2017.v10i11.20270

Authors

Balakrishna V Department of Pharmacology, Guru Nanak Institutions Technical Campus, School of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana,India. http://orcid.org/0000-0001-6802-9828
Lakshmi T Department of Pharmacology, Guru Nanak Institutions Technical Campus, School of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana,India. http://orcid.org/0000-0001-6664-988X

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i11.20270

Keywords:

Terminalia chebula, Ethanol, Hepatotoxicity, Silymarin, Extract of Terminalia chebula

Abstract

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Â Objective: The purpose of this study was to evaluate the effect of Terminalia chebula fruit extract on liver antioxidant enzymes in ethanol-induced hepatotoxicity in rats.

Method: Rats were divided into six different groups each having six. Group 1 served as a control, Group 2 received 40% ethanol (2 ml/100 g, oral), in sterile water, Groups 4, 5, and 6 served as extract treatment groups and received 50, 100, and 200 mg/kg, orally, ethanolic fruit extract of T. chebula (TCE) and Group 3 served as standard group and received silymarin 25 mg/kg orally. All the treatment protocols followed 21 days, and after which rats were sacrificed, the liver was taken for antioxidant and histological studies, respectively.

Results: The ethanol-treated group rats (G2) showed variable decrease in antioxidant parameter (catalase, glutathione, and glutathione reductase) levels. Administration of ethanolic TCE significantly prevented ethanol-induced elevation in the levels of malondialdehyde lipid peroxidation and decreased antioxidant parameters in experimental groups of rats. The effect of extract was compared with a standard drug, silymarin. The changes in antioxidant parameters were supported by histological profile.

Conclusion: It is concluded that the ethanolic fruit TCE protects against ethanol-induced oxidative liver injury in rats.

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Author Biographies

Balakrishna V, Department of Pharmacology, Guru Nanak Institutions Technical Campus, School of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana,India.

pharmacology

Lakshmi T, Department of Pharmacology, Guru Nanak Institutions Technical Campus, School of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana,India.

PHARMACOLOGY

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