THE CURRENT SCREENING TECHNOLOGIES OF GENE EXPRESSION PROFILE IN DIABETES MELLITUS

Holifa Saheera Asmara; Mainul Haque

doi:10.22159/ajpcr.2017.v10i8.20420

Authors

Holifa Saheera Asmara Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia
Mainul Haque Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defense University of Malaysia), Kem Sungai Besi, 57000 Kuala Lumpur Malaysia), Kem Sungai Besi, 57000 Kuala Lumpur, Malaysia. http://orcid.org/0000-0002-6124-7993

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i8.20420

Keywords:

Gene Expression, Microarray, Real Time PCR, Next Gene Sequencing, Diabetes

Abstract

Diabetes is commonly observed as a complexity and alteration of metabolic pathways through the oxidative stress and inflammations. It is a chronic condition, which has shown adverse effects and damages mechanisms. A broad study involving latest technologies has been conducted to view the alteration of gene expressions in order to understand the underlying of diabetes complications, a high rank of mortal disease worldwide, which demands a high cost of treatments and medications. Current technology has engaged with the method of gene expression detection, which is available in the laboratory settings, includes microarray system, real-time PCR (RT-PCR) and next gene sequencing (NGS). The output from gene expressions studies contributes to a better understanding of the molecular mechanism, promising a better possible gene target therapy and preventions.

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Author Biographies

Holifa Saheera Asmara, Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia

Biochemistry

Mainul Haque, Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defense University of Malaysia), Kem Sungai Besi, 57000 Kuala Lumpur Malaysia), Kem Sungai Besi, 57000 Kuala Lumpur, Malaysia.

Pharmacology

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