HEPATOPROTECTIVE EFFECT OF CHENOPODIUM QUINOA SEED AGAINST CCL4-INDUCED LIVER TOXICITY IN SWISS ALBINO MALE MICE
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i11.20918Keywords:
Quinoa seed, Carbon tetrachloride, Liver marker enzymes, Histopathological studiesAbstract
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 Objective: To study the effect of Quinoa seed on carbon tetrachloride (CCL4)-induced liver toxicity in Swiss albino male mice.
Methods: Swiss albino male mice were divided into three groups: Group 1 served as control group; Group 2 served as hepatotoxic group (CCl4 treated); and Group 3 served as combination of Quinoa seed powder (20 mg/kg) + CCl4-treated group. The effect of these groups on liver tissue was studied after three different periods of 4, 8, and 12 weeks. Liver marker enzyme level of serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, serum alkaline phosphatase and liver antioxidant enzyme level of lipid peroxidation, superoxide dismutase, and reduced glutathione were measured. Further, histopathological analysis of liver was also conducted.
Results: The results showed that the treatment with Quinoa seed powder significantly reduced CCl4-induced elevated serum level of hepatic enzymes and restored the level of liver antioxidant enzymes toward the normal levels, which was also confirmed by histopathological studies.
Conclusion: Results of the present study concluded that the Quinoa seed (Chenopodium quinoa) showed hepatoprotective effect against CCl4-induced liver damage in Swiss albino male mice.
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