AMELIORATION OF ALUMINUM- AND FLUORIDE-INDUCED BEHAVIORAL ALTERATIONS THROUGH RESVERATROL IN RATS.
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i1.21620Keywords:
Aluminum, Fluoride, Resveratrol, Weight, BehaviorAbstract
 Objective: The objective of the study was to investigate the ameliorative effects of resveratrol against aluminum- and fluoride-altered neurobehavioral activities.
Methods: Aluminum chloride (100 mg/kg body weight [bw])+sodium fluoride (10 mg/kg bw), aluminum chloride (100 mg/kg bw) + sodium fluoride (10 mg/kg bw) + resveratrol (30 mg/kg bw), and resveratrol (30 mg/kg bw) alone were given orally to II, III, and IV groups, respectively, and Group-I was served as control for 8 weeks. The bw, brain weight, grip strength, learning ability, and behavioral activities were assayed.
Results: The results showed significantly (*p<0.05) altered body and brain weights, learning ability, grip strength, and behavioral activities in Group- II, whereas significant (*p<0.05) reversal was observed in Group-III.
Conclusion: Taken together, the above findings conclude that resveratrol ameliorated aluminum and fluoride-altered neurobehavioral activities.
Downloads
References
Flarend R, Bin T, Elmore D, Hem SL. A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26. Food Chem Toxicol 2001;39:163-8.
Flarend RE, Hem SL, White JL, Elmore D, Suckow MA, Rudy AC, et al. In vivo absorption of aluminium-containing vaccine adjuvants using 26Al. Vaccine 1997;15:1314-7.
Walton J, Tuniz C, Fink D, Jacobsen G, Wilcox D. Uptake of trace amounts of aluminum into the brain from drinking water. Neurotoxicology 1995;16:187-90.
Yokel RA, Rhineheimer SS, Brauer RD, Sharma P, Elmore D, McNamara PJ. Aluminum bioavailability from drinking water is very low and is not appreciably influenced by stomach contents or water hardness. Toxicology 2001;161:93-101.
Zatta P, Favarato M, Nicolini M. Deposition of aluminum in brain tissues of rats exposed to inhalation of aluminum acetylacetonate. Neuroreport 1993;4:1119-22.
Langcake P, Pryce R. The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury. Physiol Plant Pathol 1976;9:77-6.
Soleas GJ, Dam J, Carey M, Goldberg DM. Towards the fingerprinting of wines: Cultivar-related patterns of polyphenolic constituents in Ontario wines. J Agric Food Chem 1997;45:3871-80.
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: The in vivo evidence. Nat Rev Drug Discov 2006;5:493-506.
Cottart CH, Nivet-Antoine V, Beaudeux JL. Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans. Mol Nutr Food Res 2014;58:7-21.
Rai AR, Madhyastha S, Prabhu LV, Saralaya VV, Sahu SS, Rao G. Resveratrol reverses the restraint stress-induced cognitive dysfunction involving brain antioxidant system in rats. Int J Pharm Pharm Sci 2014;6:768-72.
Lalitha V, Korah MC, Sengottuvel S, Sivakumar T. Antidiabetic and antioxidant activity of resveratrol and vitamin-c Combination on streptozotocin induced diabetic rats. Int J Pharm Pharm Sci 2015;7:455-8.
McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev 2013;2013:575482.
Kasiotis KM, Pratsinis H, Kletsas D, Haroutounian SA. Resveratrol and related stilbenes: Their anti-aging and anti-angiogenic properties. Food Chem Toxicol 2013;61:112-20.
Nalagoni CS, Karnati PR. Protective effect of resveratrol against neuronal damage through oxidative stress in cerebral hemisphere of aluminum and fluoride treated rats. Interdiscip Toxicol 2016;9:78-82.
Jones BJ, Roberts DJ. The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod. J Pharm Pharmacol 1968;20:302-4.
Seibenhener ML, Wooten MC. Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice. J Vis Exp 2015;96:e52434.
Winocur G, Moscovitch M. Hippocampal and prefrontal cortex contributions to learning and memory: Analysis of lesion and aging effects on maze learning in rats. Behav Neurosci 1990;104:544-51.
Cherrot G, Desor D, Huntin MF, Burel D, Capoleghil B, Lehr PR. Effects of aluminum chloride on normal and uremic adult male rats: Tissue distribution, brain choline, acetyl transferase activity and some biological variable. Biol Trace Elem Res 1995;54:43-53.
Rani A, Neha, Sodhi RK, Kaur A. Protective effect of a calcium channel blocker diltiazem†on aluminum chloride-induced dementia in mice. Naunyn Schmiedebergs Arch Pharmacol 2015;388:1151-61.
Sharma P, Ahmad SZ, Kumar A, Islam F, Mishra KP. Role of combined administration of iron and glutathione against aluminum induced oxidative stress in rat brain. J Trace Elem Med Biol 2007;21:63-70.
Evans HL. Markers of neurotoxicity: From behavior to autoantibodies against brain proteins. Clin Chem 1995;41:1874-81.
Vanguilder HD, Freeman WM. The hippocampal neuroproteome with aging and cognitive decline: Past progress and future directions. Front Aging Neurosci 2011;3:8.
Ferreira PC, Piai Kde A, Takayanagui AM, Segura-Muñoz SI. Aluminum as a risk factor for Alzheimer’s disease. Rev Lat Am Enfermagem 2008;16:151-7.
Sánchez-Iglesias S, Méndez-Alvarez E, Iglesias-González J, Muñoz-Patiño A, Sánchez-Sellero I, Labandeira-GarcÃa JL, et al. Brain oxidative stress and selective behaviour of aluminium in specific areas of rat brain: Potential effects in a 6-OHDA-induced model of Parkinson’s disease. J Neurochem 2009;109:879-88.
Bhalla P, Garg ML, Dhawan DK. Protective role of lithium during aluminium-induced neurotoxicity. Neurochem Int 2010;56:256-62.
Lu H, Hu J, Li J, Pang W, Hu Y, Yang H, et al. Optimal dose of zinc supplementation for preventing aluminum-induced neurotoxicity in rats. Neural Regen Res 2013;8:2754-62.
Yu L, Jiang R, Su Q, Yu H, Yang J. Hippocampal neuronal metal ion imbalance related oxidative stress in a rat model of chronic aluminum exposure and neuroprotection of meloxicam. Behav Brain Funct 2014;10:6.
Walton JR. Cognitive deterioration and associated pathology induced by chronic low-level aluminum ingestion in a translational rat modelprovides an explanation of Alzheimer’s disease, tests for susceptibility and avenues for treatment. Int J Alzheimers Dis 2012;2012:914947.
Zhang ZJ, Qian YH, Hu HT. The herbal medicine Dipsacus asper wall extract reduces the cognitive deficits and over expression of beta amyloid protein induced by aluminum exposure. Life Sci 2003;73:2443-54.
Canales JJ, Corbalán R, Montoliu C, Llansola M, Monfort P, Erceg S, et al. Aluminium impairs the glutamate-nitric oxide-cGMP pathway in cultured neurons and in rat brain in vivo: Molecular mechanisms and implications for neuropathology. J Inorg Biochem 2001;87:63-9.
Foti Cuzzola V, Ciurleo R, Giacoppo S, Marino S, Bramanti P. Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: Focus on recent discoveries. CNS Neurol Disord Drug Targets 2011;10:849-62.
Novelle MG, Wahla D, Diéguez C, Bernier M, de Cabo R. Resveratrol supplementation: Where are we now and where should we go? Ageing Res Rev 2015;21:1-15.
Sun AY, Wang Q, Simonyi A, Sun GY. Resveratrol as a therapeutic agent for neurodegenerative diseases. Mol Neurobiol 2010;41:375-83.
Gonda Z, Lehotzky K, Miklósi A. Neurotoxicity induced by prenatal aluminum exposure in rats. Neurotoxicology 1996;17:459-69.
Hu H, Yang YJ, Li XP, Chen GH. Effect of aluminum chloride on motor activity and species-typical behaviors in mice. Zhonghua Lao DongWei Sheng Zhi Ye Bing Za Zhi 2005;23:132-5.
Golub MS, Donald JM, Gershwin ME, Keen CL. Effects of aluminum ingestion on spontaneous motor activity of mice. Neurotoxicol Teratol 1989;11:231-5.
Abdel-Aal RA, Assi AA, Kostandy BB. Rivastigmine reverses aluminum-induced behavioral changes in rats. Eur J Pharmacol 2011;659:169-76.
Erazi H, Sansar W, Ahboucha S, Gamrani H. Aluminum affects glial system and behavior of rats. C R Biol 2010;333:23-7.
Liang RF, Li WQ, Wang H, Wang JX, Niu Q. Impact of sub-chronic aluminium-maltolate exposure on catabolism of amyloid precursor protein in rats. Biomed Environ Sci 2013;26:445-52.
Li N, Wang XY, Liu CC, Zhang QL, Niu Q. The effects of caspase-3 siRNA on the neurobehavior of mice exposed to aluminum. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2011;29:343-8.
Huang TC, Lu KT, Wo YY, Wu YJ, Yang YL. Resveratrol protects rats from Aß-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation. PLoS One 2011;6:e29102.
Lu KT, Ko MC, Chen BY, Huang JC, Hsieh CW, Lee MC, et al. Neuroprotective effects of resveratrol on MPTP-induced neuron loss mediated by free radical scavenging. J Agric Food Chem 2008;56:6910-3.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
