SYNERGISTIC ANTICANDIDAL ACTIVITY OF TWO TERMINALIA SPECIES WITH POLYENE AND AZOLE GROUP OF ANTIBIOTICS AGAINST MULTIDRUG-RESISTANT CLINICAL ISOLATES OF CANDIDA

Tejas Rathod; Hemali Padalia; Sumitra Chanda

doi:10.22159/ajpcr.2018.v11i1.21664

Authors

Tejas Rathod Department of Biosciences (UGC-CAS), Phytochemical, Pharmacological and Microbiological Laboratory, Saurashtra University, Rajkot - 360 005, Gujarat, India
Hemali Padalia Department of Biosciences (UGC-CAS), Phytochemical, Pharmacological and Microbiological Laboratory, Saurashtra University, Rajkot - 360 005, Gujarat, India
Sumitra Chanda Department of Biosciences (UGC-CAS), Phytochemical, Pharmacological and Microbiological Laboratory, Saurashtra University, Rajkot - 360 005, Gujarat, India

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i1.21664

Keywords:

Terminalia chebula, Terminalia catappa, Antibiotics, Fluconazole, Synergistic activity, Anticandidal agent

Abstract

Objectives: The aim of the present study was to evaluate synergistic anticandidal activity of two Terminalia species with polyene and azole group of antibiotics against multidrug-resistant clinical isolates of Candida.

Methods: The synergistic effect of ethanol extract of leaf of Terminalia cattapa. and Terminalia chebula with six standard antibiotics, namely, amphotericin B, nystatin, fluconazole (FLC), ketoconazole (KT), clotrimazole (CC), and itraconazole (IT) was evaluated against the clinical isolates by disk diffusion assay.

Results: The synergistic activity of the antibiotics with ethanol extract of T. chebula was better than with that of T. cattapa. T. chebula ethanol extract increased the anticandidal effect of azole antibiotics FLC and KT, while it had a less synergistic effect on CC and IT.

Conclusion: Therefore, FLC/KT plus ethanol extract of T. chebula can be an interesting and alternative source of anticandidal agent against Candida species.

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