EVALUATION OF ANTICANCER ACTIVITY OF PARKINSONIA ACULEATA LEAVES EXTRACT ON EHRLICH'S ASCITES CARCINOMA-INDUCED MICE.
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i1.22404Keywords:
Ehrlich ascites carcinoma induced model, Anticancer, Parkinsonia aculeata, 5-fluorouracilAbstract
 Objective: The objective of the study was to investigate the anticancer activity of the ethanolic extract of Parkinsonia aculeata (EEPA) leaves.
Methods: Anticancer activity of P. aculeata (EEPA) of leaf extract was evaluated in Swiss albino mice against Ehrlich ascites carcinoma (EAC) cell line at the doses of 200 and 400 mg/kg body weight orally. The extracts were administered for 14 consecutive days. 24 h of the last dose and 18 h of fasting, the mice were sacrificed, and the anticancer effect of EEPA was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight, hematological parameters, and biochemical parameters of EAC bearing mice.
Results: P. aculeata extracts showed a significant decrease in (p<0.01) tumor volume, viable cell count, tumor weight, and elevated the life span of EAC bearing mice. Hematological profile such as red blood cell, hemoglobin count reverted to normal level in EEPA treated mice. The extracts significantly (p<0.05) decreased the levels of lipid peroxidation and significantly (p<0.05) increased the levels of reduced glutathione, superoxide dismutase and catalase.
Conclusion: The results showed that the EEPA was effective in inhibiting the tumor growth in ascitic models and that is comparable to 5-fluorouracil.
Â
Downloads
References
Gennari C, Castoldi D, Sharon O. Natural products with taxol-like anti-tumor activity: Synthetic approaches to eleutherobin and dictyostatin. Pure Appl Chem 2007;79:173-80.
Khlifi S, EI Hachimi Y, Khalil Y, Khalil Y, Khalil A, ES-Safi N, et al. In vitro antioxidant properties of Salvia verbenaca L. hydromethanolic extract. Indian J Pharmacol 2006;38:276-80.
Albrecht J, editor. Tree Seed Handbook of Kenya. Nairobi, Kenya: GTZ Forestry Seed Center Muguga; 1993.
Singh P, Shrivastava R, Saxena R, Sharma M, Karchuli M, Tripathi J. Phytochemical screening and evaluation of antioxidant activity of Parkinsonia aculeate L. (Family-Leguminoseae) leaves extract. IJPRIF 2011;3:1952-17.
Kamal R, Mathur N. Rotenoids from Parkinsonia aculeata L and their in vitro. amoebicidal activity. Asian J Exp Sci 2007;21:317-23.
Patel P, Jivani NP, Malaviya SV, Bhalodia Y. Phytochemical study and antiparkinson’s activity of Parkinsonia aculeata and Ananas comosus L. effect on haloperidol induced catalepsy. Ethnopharmacology 2014;2014:17.
Gupta MK, Kenganora M, Banerjee A, Saini L, Kuma V. Pharmacognostical and phytochemical evaluation on the bark of Parkinsonia aculeata Linn. J Pharm Sci Biosci Res 2011;1:86-92.
Divya B, Mruthunjaya K, Manjula SN. Parkinsonia aculeata: Phytopharmacological review. Asian J 2008;4:1-7.
Priyam S, Rajni S, Manik S, Manvendra S. In vivo antitumor, antioxidant activities and toxicity profile of ethyl acetate crude leaf extract of Parkinsonia equality on B16F10 Melanoma. Int Res J Pharma 2013;4:89.
Gupta M, Mazumder UK, Kumar RS, Sivakumar T, Vamsi ML. Antitumor activity and antioxidant status of Caesalpinia bonducella against ehrlich ascites carcinoma in Swiss albino mice. J Pharmacol Sci 2004;94:177-84.
Aishwarya V, Abdulla SS, Dheeba B, Renuka R. In vitro antioxidant and anticancer activity of Cardiospermum halicacabum L. against EAC cell line. Int J Pharm Pharm Sci 2014;6:263-8.
Ahuja R, Agrawal N, Mukerjee A. Evaluation of the anticancer potential of Terminalia chebula fruits against ehrlich ascites carcinoma induced cancer in mice. J Sci Innov Res 2013;2:549-54.
Muralidhar A, Somasekhar A, Sumanjali A, Kumar BP. Anticancer activity of Tephrosia purpurea root extracts against ehrlich ascites carcinoma (EAC) cells in Swiss albino mice. Pharm Sin 2014;5:81-7.
Segura JA, Barero LG, Marquez J. Elrich ascites tumor unbalanced splenic cell population and reduced responsiveness of T cell to Staphylococcus. Immunomol Lett 2000;74:111-15.
Harborne JB, Williams CA. Advances in flavonoid research since 1992. Phytochemistry 2000;55:481-4.
D’Armour FE, Blood FR, Belden DA. The Manual for Laboratory Work in Mammalian Physiology. 3rd ed. Chicago: The University of Chicago; 1965.
Bala A, Kar B, Haldar PK, Mazumder UK, Bera S. Evaluation of anticancer activity of Cleome gynandra on ehrlich’s ascites carcinoma treated mice. J Etna Pharmacol 2010;129:131-4.
Sreelatha S, Padma PR, Umasankari E. Evaluation of anticancer activity of ethanol extract of Sesbania grandiflora (Agati sesban) against ehrlich ascites carcinoma in Swiss albino mice. J Ethnopharmacol 2011;134:984-7.
Gupta M, Mazumder UK, Rath N, Mukhopadhyay DK. Antitumor activity of methanolic extract of Cassia fistula L. Seed against ehrlich ascites carcinoma. J Ethnopharmacol 2000;72:151-6.
Naveena, Bharath BK, Selvasubramanian. Antitumor activity of Aloe vera against ehrlich ascitis carcinoma (Eac) in Swiss albino mice. Int J Pharm Bio Sci 2011;2:400-9.
Arora S, Agarwal S, Singhal S. Anticancer activities of thiosemicarbazides/thiosemicarbazones: A review. Int J Pharm Pharm Sci 2014;6:1179-85.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
