FLAVONOIDS NUTRACEUTICALS IN PREVENTION AND TREATMENT OF CANCER: A REVIEW
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i1.23410Keywords:
Medicinal plants, Flavonoid, Cancer prevention, Antiproliferation, Apoptosis, Antioxidative, Multidrug resistance, AngiogenicAbstract
The objective of the study was to discuss the preventive and treatment of cancer from flavonoids nutraceuticals from our daily dietary source. There has been increasing interest in the research of flavonoids from dietary sources, due to growing evidence of the versatile health benefits of flavonoids through epidemiological studies. Numerous biological activities have been reported. Some clinical trials or meta-analyses have suggested positive associations between flavonoid intake and human health, Several findings have proven that dietary flavonoids to have anticancer properties. Flavonoids due to their nontoxicity in nature and vast, broad aspect of its benefits in biological activities have been intensively studied for their health benefits also added to its abundant availability in our daily diets, for example, green leaves, fruits, red wine, and tea vegetables.
Downloads
References
Gupta J, Siddique YH, Beg T, Ara G, Afzal M. A review on the beneficial effect of tea polyphenols on human health. Int J Pharmacol 2008;4;314-38.
Lalawmpuii PC, Malsawmtluangi C, AQ3 Zothanpuia, Kakoti BB. Phytochemical screening and determination of antioxidant activity of Helicia nilagirica Bedd., an ethnomedicinal plant of Mizoram, India. Asian J Pharm Clin Res 2014;7:246-9.
Shrishail D, Harish KH, Ravichandra H, Tulsianand G, Shruthi SD. Turmeric: Nature’s precious medicine. Asian J Pharm Clin Res 2013;6;10-6.
Ren W, Qiao Z, Wang H, Zhu L, Zhang L. Flavonoids: Promising anticancer agents. Med Res Rev 2003;23:519-34.
Yao LH, Jiang YM, Shi J, Tomás-Barberán FA, Datta N, Singanusong R, et al. Flavonoids in food and their health benefits. Plant Foods Hum Nutr 2004;59:113-22.
Park EJ, Pezzuto JM. Flavonoids in cancer prevention. Anticancer Agents Med Chem 2012;12:836-51.
Kaur R, Arora S. Alkaloids-important therapeutic secondary metabolites of plant origin. J Crit Rev 2015;2:1-8.
Hollman PC, Katan MB. Dietary flavonoids: Intake, health effects and bioavailability. Food Chem Toxicol 1999;37:937-42.
Craig WJ. Health-promoting properties of common herbs. Am J Clin Nutr 1999;70:491S-9S.
Middleton E Jr., Kandaswami C, Theoharides TC . The effects of plant flavonoids on mammalian cells : Implications for inflammation, heart disease and cancer. J Biotech Biomater 2016;6:232-9.
Birt DF, Hendrich S, Wang W. Dietary agents in cancer prevention: Flavonoids and isoflavonoids. Pharmacol Ther 2001;90:157-77.
Webster KR. The therapeutic potential of targeting the cell cycle. Exp Opin Investig Drugs 1998;7:865-87.
Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Cancer 1992;18:1-29.
Wendeu-Foyet MG, Menegaux F. Circadian disruption and prostate cancer risk: An updated review of epidemiological evidences. Cancer Epidemiol Biomarkers Prev 2017;26:985-91.
Shi YQ, Fukai T, Sakagami H, Chang WJ, Yang PQ, Wang FP, et al. Cytotoxic flavonoids with isoprenoid groups from morus mongolica. J Nat Prod 2001;64:181-8.
Han D, Tachibana H, Yamada K. Inhibition of environmental estrogen-induced proliferation of human breast carcinoma MCF-7 cells by flavonoids. In Vitro Cell Dev Biol Anim 2001;37:275-82.
Preedy VR. Apoptosis. Enfield, N.H: Science Publishers; 2010.
Bai F, Matsui T, Ohtani-Fujita N, Matsukawa Y, Ding Y, Sakai T, et al. Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells. FEBS Lett 1998;437:61-4.
Deep G, Agarwal R. Chemopreventive efficacy of silymarin in skin and prostate cancer. Integr Cancer Ther 2007;6:130-45.
Knowles LM, Zigrossi DA, Tauber RA, Hightower C, Milner JA. Flavonoids suppress androgen-independent human prostate tumor proliferation. Nutr Cancer 2000;38:116-22.
Hakimuddin F, Paliyath G, Meckling K. Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells. Breast Cancer Res Treat 2004;85:65-79.
Kuntz S, Wenzel U, Daniel H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur J Nutr 1999;38:133-42.
Wang IK, Lin-Shiau SY, Lin JK. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 1999;35:1517-25.
Csokay B, Prajda N, Weber G, Olah E. Molecular mechanisms in the antiproliferative action of quercetin. Life Sci 1997;60:2157-63.
Iwashita K, Kobori M, Yamaki K, Tsushida T. Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci Biotechnol Biochem 2000;64:1813-20.
Relling MV, Evans RR, Groom S, Crom WR, Pratt CB. Saturable elimination and saturable protein binding account for flavone acetic acid pharmacokinetics. J Pharmacokinet Biopharm 1993;21:639-51.
Ferry R. Phase I clinical trial of the flavonoid tyrosine kinase quercetin : Pharmacokinetics for in vivo. Clin Cancer Res 1996;2;659-68.
Mulholland PJ, Ferry DR, Anderson D, Hussain SA, Young AM, Cook JE, et al. Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin. Ann Oncol 2001;12:245-8.
Karimi G, Vahabzadeh M, Lari P, Rashedinia M, Moshiri M. Silymarinâ€, a promising pharmacological agent for treatment of diseases. Iran J Basic Med Sci 2011;14:308-17.
Zhao C, Feng X, Tang T, Qiu L. Isolation and expression analysis of CYP9A11 and cytochrome P450 reductase gene in the beet armyworm (Lepidoptera: Noctuidae). J Insect Sci 2015;15:122.
Nagao A, Seki M, Kobayashi H. Inhibition of xanthine oxidase by flavonoids. Biosci Biotechnol Biochem 1999;63:1787-90.
Senderowicz AM. Flavopiridol: The rst cyclin-dependent kinase inhibitor in human clinical trials. Invest New Drugs 1999;17:313-20.
Senderowicz AM. Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies. Leukemia 2001;15:1-9.
Markovits J, Linassier C, Fossé P, Couprie J, Pierre J, Jacquemin-Sablon A, et al. Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res 1989;49:5111-7.
Bailly C. Topoisomerase I poisons and suppressors as anticancer drugs. Curr Med Chem 2000;7:39-58.
Yoon G, Kang BY, Cheon SH. Topoisomerase I inhibition and cytotoxicity of licochalcones A and E from glycyrrhiza inflata. Arch Pharm Res 2007;30:313-6.
Yu JS, Kim AK. Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells. Mol Cells 2011;31:327-35.
Takahashi T, Kobori M, Shinmoto H, Tsushida T. Structure-activity relationships of flavonoids and the induction of granulocytic- or monocytic-differentiation in HL60 human myeloid leukemia cells. Biosci Biotechnol Biochem 1998;62:2199-204.
Adlercreutz H. Phytoestrogens: Epidemiology and a possible role in cancer protection. Environ Health Perspect 1995;103:103-12.
Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: An overview. Methods Enzymol 1990;186:1-85.
Halliwell B. Free radicals and antioxidants: A personal view. Nutr Rev 1994;52:253-65.
Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA, et al. Flavonoids: A review of probable mechanisms of action and potential applications. Am J Clin Nutr 2001;74:418-25.
Tosetti F, Ferrari N, De Flora S, Albini A. Angioprevention’: Angiogenesis is a common and key target for cancer chemopreventive agents. FASEB J 2002;16:2-14.
Kioka N, Hosokawa N, Komano T, Hirayoshi K, Nagata K, Ueda K, et al. Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite. FEBS Lett 1992;301:307-9.
Kiessling R, Klein E, Wigzell H. Natural killer cells in the mouse. Eur J Immunol 1975;5:112-7.
Sutlu T, Alici E. Natural killer cell-based immunotherapy in cancer: Current insights and future prospects. J Intern Med 2009;266:154-81.
Russo GL, Tedesco I, Spagnuolo C, Russo M. Antioxidant polyphenols in cancer treatment: Friend, foe or foil? Semin Cancer Biol 2017;46:1-3.
Rafiq RA, Quadri A, Nazir LA, Peerzada K, Ganai BA, Tasduq SA, et al. A potent inhibitor of phosphoinositide 3-kinase (PI3K) and mitogen activated protein (MAP) kinase signalling, quercetin (3, 3’, 4’, 5, 7-pentahydroxyflavone) promotes cell death in ultraviolet (UV)-B-irradiated B16F10 melanoma cells. PLoS One 2015;10:e0131253.
Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, et al. Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line. Food Chem Toxicol 2013;60:377-84.
Raina K, Agarwal C, Wadhwa R, Serkova NJ, Agarwal R. Energy deprivation by silibinin in colorectal cancer cells: A double-edged sword targeting both apoptotic and autophagic machineries. Autophagy 2013;9:697-713.
Khan HY, Zubair H, Faisal M, Ullah MF, Farhan M, Sarkar FH, et al. Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: A mechanism for cancer chemopreventive action. Mol Nutr Food Res 2014;58:437-46.
Dai F, Liu GY, Li Y, Yan WJ, Wang Q, Yang J, et al. Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids. Free Radic Biol Med 2015;85:127-37.
Jing X, Cheng W, Wang S, Li P, He L. Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN-regulated PI3K/Akt signaling pathway. Oncol Rep 2016;35:472-8.
Xie J, Yun JP, Yang YN, Hua F, Zhang XW, Lin H, et al. A novel ECG analog 4-(S)-(2,4,6-trimethylthiobenzyl)-epigallocatechin gallate selectively induces apoptosis of B16-F10 melanoma via activation of autophagy and ROS. Sci Rep 2017;7:42194.
Shin SY, Lee JM, Lee MS, Koh D, Jung H, Lim Y, et al. Targeting cancer cells via the reactive oxygen species-mediated unfolded protein response with a novel synthetic polyphenol conjugate. Clin Cancer Res 2014;20:4302-13.
Amawi H, Ashby CR, Samuel T, Peraman R, Tiwari AK. Polyphenolic nutrients in cancer chemoprevention and metastasis: Role of the epithelial-to-mesenchymal (EMT) pathway. Nutrients 2017;9:911.
Meiyanto E, Hermawan A, Anindyajati A. Natural products for cancer-targeted therapy: Citrus flavonoids as potent chemopreventive agents. Asian Pacific J Cancer Prev 2012;13:427-36.
Klimaszewska-Wisniewska A, Halas-Wisniewska M, Tadrowski T, Gagat M, Grzanka D, Grzanka A, et al. Paclitaxel and the dietary flavonoid fisetin: A synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells. Cancer Cell Int 2016;16:10.
Kumar M, Sasmita S. Colon targeted drug delivery system-an approach for treating colonic ailments. J Crit Rev 2015;2: ???.
Park MH, Hong JE, Hwang CJ, Choi M, Choi JS, An YJ, et al. Synergistic inhibitory effect of cetuximab and tectochrysin on human colon cancer cell growth via inhibition of EGFR signal. Arch Pharm Res 2016;39:721-9.
Hirata Y, Tatsu M, Amano C, Kawaratani Y, Hirata1 M, Ohmomo Y. Synergistic antitumor effect of genitinib (Iressa) with flavonoids from the root on the non-small cell lung cells. Open Plant Sci J 2017;10;62-9.
So FV, Guthrie N, Chambers AF, Moussa M, Carroll KK. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer 1996;26:167-81.
Liu HL, Jiang WB, Xie MX. Flavonoids: Recent advances as anticancer drugs. Recent Pat Anticancer Drug Discov 2010;5:152-64.
Fr N, Schutze F. (12) United States Patent; 2005;. p. 5-11.
Cotter RJ. (12) United States Patent No. 5,908,690; 2003. p. 1.
Nandakumar V, Singh T, Katiyar SK. Multi-targeted prevention and therapy of cancer by proanthocyanidins. Cancer Lett 2008;269:378-87.
Budiman ES, Zhang S. United States (12) No. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 26. 27. 28. 29. 30. 31. 32; 2014. p. 1.
Application F, Data P, Ciattini R. (19) United States; 2008.
Bstract A. (19) United States (12) Patent Application Publication; 2002. p. 1.
Llp B, Docketing P, Street E. (19) United States (12); 2008.
El-toumy SA, Salib JY, Shafik NH, Elkarim AS, Farag AA. New flavonoids from the aerial parts of polygonum equisetiforme sm (Polygonaceae). Int J Pharm Pharm Sci 2017;9:166-70.
Sambandam B, Thiyagarajan D, Ayyaswamy A, Raman P, Kulasekaran J, Venkatasamy H, et al. Extraction and isolation of flavonoid quercetin from the leaves of Trigonella foenum-graecum and their anti-oxidant activity. Int J Pharm Pharm Sci 2016;8:120-4.
Sundaram KM, Nanthini UR, Yadav SA, Thangavel S. Anti-oxidant and anti-microbial activities of synthetic 3-formyl, 7-flavonol intermediates obtained by microwave assisted technique. Int J Pharm Pharm Sci 2015;7:124-8.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
