ANTIPYRETIC POTENTIAL OF AQUEOUS LEAF EXTRACT OF ANNONA MURICATA.L AND SPERMACOCE ARTICULARIS. L.F. ON YEAST-INDUCED PYREXIA IN RATS

Maruvoor Arasi K; Krishnaveni C

doi:10.22159/ajpcr.2018.v11i3.22728

Authors

Maruvoor Arasi K Department of Botany, PSGR Krishnammal College for Women (Autonomous), Coimbatore-641004, Tamil Nadu, India.
Krishnaveni C Department of Botany, PSGR Krishnammal College for Women (Autonomous), Coimbatore-641004, Tamil Nadu,India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i3.22728

Keywords:

Annona muricata L, Antipyretic activity, Nil, Spermacoce articularis Lf, Pyrexia

Abstract

Â Objective: The objective of this study is to evaluate the potential of in vivo antipyretic activity of the aqueous leaf extracts of Annona muricata L. and Spermacoce articularis. L.f.

Methods: The acute oral toxicity was determined by the Organization of Economic and Cooperation Development-423 class methods, and the in vivo antipyretic activity was determined by brewer's yeast induced pyrexia method.

Results: The results showed that the aqueous leaf extract of A. muricata. L and S. articularis L.f plants is non-toxic and possessed significant antipyretic effect.

Conclusion: This study provides evidence for the antipyretic activity of A. muricata. L and S. articularis L.f. The aqueous leaf extract of S. articularis L.f at a dose of 400 mg/kg showed a more significant effect (p<0.01) in lowering the hypothermia than the extract of A. muricata L but found to have a similar effect as the standard drug aspirin (100 mg/kg).

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Author Biography

Maruvoor Arasi K, Department of Botany, PSGR Krishnammal College for Women (Autonomous), Coimbatore-641004, Tamil Nadu, India.

department of Botany

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