NEW COMBINATION SUPPOSITORIES OF LORNOXICAM AND ALOIN FOR RHEUMATOID ARTHRITIS
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i2.22921Keywords:
Lornoxicam, Aloin, Rectal suppositories, Anti-inflammatory, Polyethylene glycolAbstract
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 Objective: The objective of our current work is to formulate, optimize and evaluate new combination rectal suppositories as a treatment for rheumatoid arthritis that contains both lornoxicam and aloin. Both are strong anti-inflammatory agents, and a combination of both may have synergistic effect as an anti-inflammatory treatment.
Methods: Rectal suppositories containing 8 mg lornoxicam and 200 mg aloin were formulated by heat fusion method. Different combinations of different molecular weights of polyethylene glycol (PEG) were used for the formulated suppositories. The formulated suppositories were evaluated for their visual appearance, weight variation, hardness, friability, disintegration time, melting temperature, and drug content uniformity.
Results: All the formulations prepared were within the required limits for USP. When the release study was performed, both drugs were released from all the formulations prepared. However, formulation F7 which is composed of PEG 400 30.88% (w/w): PEG 4000 46.32% (w/w) was superior to other formulations in which more than 80% of both drugs loaded were released after 35 min. The presence of both drugs in the same suppository did not affect their release.
Conclusion: A new combination suppositories have been obtained where the two combined drugs were released fast without interference with each other release. The proposed new combination has the potential to be used as a strong analgesic and anti-inflammatory treatment compared to using lornoxicam or aloin alone.
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Kristensen LE, Bliddal H, Christensen R, Karlsson JA, Gülfe A, Saxne T, et al. Is swollen to tender joint count ratio a new and useful clinical marker for biologic drug response in rheumatoid arthritis? Results from a Swedish cohort. Arthritis Care Res (Hoboken) 2014;66:173-9.
Brennan-Olsen SL, Cook S, Leech MT, Bowe SJ, Kowal P, Naidoo N,
et al. Prevalence of arthritis according to age, sex and socioeconomic status in six low and middle income countries: Analysis of data from the World Health Organization study on global AGEing and adult health (SAGE) Wave 1. BMC Musculoskelet Disord 2017;18:271.
Papana A, Meng SJ, Wei YX, Wang W, Ruth M, Page C, et al. Prevalence of rheumatoid arthritis in low-and middle-income countries. Am J Glob Health 2015;5:1-10.
Reginster JY. The prevalence and burden of arthritis. Rheumatology (Oxford) 2002;41 Supp 1:3-6.
Saag KG, Teng G, Patkar NM, Anuntiyo J, Finney C, Curtis JR, et al. American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. Arthritis Rheum 2008;59:762-84.
Kapoor B, Singh SK, Gulati M, Gupta R, Vaidya Y. Application of liposomes in treatment of rheumatoid arthritis: Quo vadis. ScientificWorldJournal 2014;2014:978351.
Macpherson J, Russell S. Side effects of nonsteroidal anti-inflammatory small and large intestine in humans. Gastroenterology 1993;104:1832-47.
Brune K, Patrignani P. New insights into the use of currently available non-steroidal anti-inflammatory drugs. J Pain Res 2015;8:105-18.
Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA 2000;284:1247-55.
Warrington SJ, Debbas NM, Farthing M, Horton M, Johnston A, Thillainayagam A, et al. Lornoxicam, indomethacin and placebo: Comparison of effects on faecal blood loss and upper gastrointestinal endoscopic appearances in healthy men. Postgrad Med J 1990;66:622-6.
Byrav DS, Medhi B, Prakash A, Patyar S, Wadhwa S. Lornoxicam: A newer NSAID. Drug Rev 2009;20:27-31.
Pushpa K, Mahesh K. An overview on plants with anti-inflammatory potential. Int J Curr Pharm Res 2017;9:1-4.
Corrêa GM, Gomes V, Costa DA, Alois D, Martins DE, Takahashi JA, et al. Anti-inflammatory and antimicrobial activities of steroids and triterpenes isolated from aerial parts of Justicia acuminatissima (Acanthaceae). Int J Pharm Pharm Sci 2014;6:75-81.
Nanjundaiah SM, Kim HR, Rajaiah R, Yang Y, Tong L, Yu H, et al. Control of autoimmune arthritis by herbal extracts and their bioactive components. Asian J Pharm Sci 2016;11:301-7.
Langmead L, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, et al. Randomized, double-blind, placebo-controlled trial of oral Aloe vera gel for active ulcerative colitis. Aliment Pharmacol Ther 2004;19:739-47.
Rohilkhand MJ, Sai S, Madan J, Sharma AK, Singh R. Fast dissolving tablets of Aloe vera Gel. Trop J Pharm Res 2009;8:63-70.
Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. J Tradit Complement Med 2014;5:21-6.
Patel K, Patel DK. Medicinal importance, pharmacological activities, and analytical aspects of aloin: A concise report. J Acute Dis 2013;2:262-9.
Park MY, Kwon HJ, Sung MK. Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Biosci Biotechnol Biochem 2009;73:828-32.
Moghimipour E, Dabbagh MA, Zarif F. Characterization and in vitro evaluation of piroxicam suppositories. Asian J Pharm Clin Res 2009;2:92-8.
British Pharmacopeial Commisssion. British Pharmacopoeia. London: The Stationery Office on Behalf of the Medicines and Healthcare Products Regulatory Agency, MHRA; 2013.
Zawar LR, Bhandari GS. Formulation and evaluation of sustained release ondansetron poloxamer based solid suppositories. J Appl Pharm Sci 2012;2:186-90.
Allen LV. Quality control of suppositories. Suppositories. 1st ed. UK: The Pharmaceutical Press; 2008. p. 139-58.
Varshney HM, Chatterjee A. Formulation, evaluation and in vitro release characterisatics of zaltoprofen suppositories. Asian J Pharm Clin Res 2012;5:235-8.
Abass H, Kamel R, Abdelbary A. Metronidazole bioadhesive vaginal suppositories: Formulation, in vitro and in vivo evaluation. Int J Pharm Pharm Sci 2012;4:344-53.
Tarkase KN, Danve AV. Formulation evaluation and in-vitro drug release characteristics of Aloe vera herbal suppositories. Der Pharm Lett 2015;7:310-6.
Baviskar P, Jaiswal S, Sadique S, Landged A. Formulation and evaluation of lornoxicam suppositories. Pharm Innov J 2013;2:20-8.
Tawfeek HM. Lornoxicam suppositories: In-vitro formulation and in-vivo evaluation. Int J Pharm Sci Res 2013;4:4228-35.
Ogundipe OD, Oladimeji FA. Quantitative analysis of the effects of
drug-base ratio on the physical and release properties of paracetamol suppositories. Pharm Innov J 2017;6:190-6.
Suryakumari C, Anusha A, Anitha P, Ravindra D. Formulation and evaluation of cow Ghee as a base fast and sustained release chloroquine phosphate suppositories. World J Pharm Pharm Sci 2014;3:1493-509.
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