DRUG PRESCRIPTION PATTERN OF BREAST CANCER PATIENTS IN A TERTIARY CARE HOSPITAL IN WEST BENGAL: A CROSS-SECTIONAL AND QUESTIONNAIRE-BASED STUDY

Anjan Adhikari; Dipesh Chakraborty; Rania Indu; Sangita Bhattacharya; Moumita Ray; Ramanuj Mukherjee

doi:10.22159/ajpcr.2018.v11i3.23180

Authors

Anjan Adhikari Department of Pharmacology, R. G. Kar Medical College, Kolkata - 700 004, West Bengal, India.
Dipesh Chakraborty Department of Pharmacology, Bengal School of Technology, Hooghly - 712 102, West Bengal, India.
Rania Indu Department of Pharmacology, R. G. Kar Medical College, Kolkata - 700 004, West Bengal, India.
Sangita Bhattacharya Department of Pharmacology, R. G. Kar Medical College, Kolkata - 700 004, West Bengal, India.
Moumita Ray Department of Pharmacology, R. G. Kar Medical College, Kolkata - 700 004, West Bengal, India.
Ramanuj Mukherjee Department of Surgery, R. G. Kar Medical College, Kolkata - 700 004, West Bengal, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i3.23180

Keywords:

Allred score, Breast carcinoma, Nottingham factor, Prescription

Abstract

Â Objective: Cancer is a disease of uncontrolled division of cells in any part of the body. Breast cancer most common in women accounts for 13% of the death worldwide. The objective of the present study was to evaluate the drug prescription pattern of breast carcinoma patients in a tertiary care hospital of West Bengal.

Methods: This was a cross-sectional observational questionnaire-based study done for a period of 6 months at the Department of Pharmacology in Collaboration with the Department of Surgery and Department of Radiotherapy of a Tertiary Care Hospital at Kolkata, West Bengal, India. Female patients with breast cancer (originated from epithelial tissues) of different types and grade attending surgery outdoor patient department were taken as subjects for the study, after signing informed consent.

Results: The present study evaluated 28 patients (n=28) diagnosed as breast cancer by the physicians of the department of surgery and radiotherapy. It was observed that breast cancer was mostly found in the middle age group. Breast carcinoma in postmenopausal women accounted to 75%. The most prevalent breast cancer was invasive ductal carcinoma, accounting to 75% of the study population. 5-Fluorouracil, epirubicin, doxorubicin, cyclophosphamide, docetaxel/paclitaxel, and carboplatin were mostly used as chemotherapeutic agent.

Conclusion: Breast carcinoma being a prevalent type of cancer in females, the present study tried to evaluate the pattern of prescribing chemotherapeutic agents for breast cancer patients in a tertiary care hospital. Such study is essential to evaluate and refine the therapeutic regimen of the cancer patients to reduce their sufferings.

Downloads

Download data is not yet available.

References

Shyamala K, Girish HC, Murgod S. Risk of tumor cell seeding through biopsy and aspiration cytology. J Int Soc Prevent Communit Dent 2014;4:5-11.

Elmore S. Apoptosis: A review of programmed cell death. Toxicol Pathol 2007;35:495-516.

Seyfried TN, Huysentruyt LC. On the origin of cancer metastasis. Crit Rev Oncog 2013;18:43-73.

Siegel RL, Miller KD, Jemal A. Cancer statistics. CA Cancer J Clin 2016;66:7-30.

Available from: http://www.cancerindia.org.in/cp/index.php/know-about-cancer/statistics. [Last accessed on 2017 Jun 15].

WHO (October 2010) Cancerâ€™. World Health Organization. Available from: [Last accessed on 2017 Jun 02].

Iyer M, Kumar PS, Karthikeyan S, Namboori PK. â€˜BRCA1â€™ responsiveness towards breast cancer-a population-wise pharmacogenomic analysis. Int J Pharm Pharm Sci 2016;9:267-70.

Green AR, Soria D, Powe DG, Nolan CC, Aleskandarany M, SzÃ¡sz MA, et al. Nottingham prognostic index plus (NPI+) predicts risk of distant metastases in primary breast cancer. Breast Cancer Res Treat 2016;157:65-75.

DaltoÃ© RD, Madeira KP, de Carvalho AA, de Rezende LC, Silva IV, Rangel LB. Evaluation of the progesterone receptor status in breast cancer using three different antibodies: A comparison by Allred score system. Int J Clin Exp Pathol 2014;7:331-9.

Reddy D, Kalyani G, Pradeep K, Asif M, Kartheek D, Gangabhavani M. The survey of cancer patients in the region of Guntur: Based on hospital registry. Int J Pharm Pharm Sci 2017;9:288-32.

Kamath R, Mahajan KS, Ashok L, Sanal TS. A study on risk factors of breast cancer among patients attending the Tertiary care hospital, in Udupi District. Indian J Community Med 2013;38:95-99.

Ozmen V, Ozcinar B, Karanlik H, Cabioglu N, Tukenmez M, Disci R, et al. Breast cancer risk factors in Turkish women a university hospital based nested case control study. World J Surg Oncol 2009;7:37.

Abbasi S, Azimi C, Othman F, Einollahi N, Dashti N, Nabatchian F, et al. Risk factors for breast cancer in Iranian women: A case control study. Int J Cancer Res 2009;5:1-11.

Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: A multicentre retrospective study. PLoS One 2010;5:e8933.

Soonmyung P, Gong T, Steven S, Chungyeul K, Joffre B, Wanseop K, et al. Gene expression and benefit of chemotherapy in women With node-negative, estrogen receptorâ€“positive breast cancer. J Clin Oncol 2006;24:3726-34.

Rebecca D, Maureen T, Kathleen IP, Wedad MH, Harriet KK, Carol AS, et al. Triple-negative breast cancer: Clinical features and patterns of recurrence. Clin Cancer Res 2007;13:4429-34.

Key T, Appleby P, Barnes I, Reeves G, Endogenous Hormones and Breast Cancer Collaborative Group. Endogenous sex hormones and breast cancer in postmenopausal women: Reanalysis of nine prospective studies. J Natl Cancer Inst 2002;94:606-16.

Surakasula A, Nagarjunapu GC, Raghavaiah KV. A comparative study of pre-and post-menopausal breast cancer: Risk factors, presentation, characteristics and management. J Res Pharm Pract 2014;3:12-18.

Butt Z, Haider SF, Arif S, Khan MR, Ashfaq U, Shahbaz U, et al. Breast cancer risk factors: A comparison between pre-menopausal and post-menopausal women. J Pak Med Assoc 2012;62:120-4.

Saxena S, Rekhi B, Bansal A, Bagga A, Chintamani, Murthy NS. Clinico-morphological patterns of breast cancer including family history in a New Delhi hospital, India â€“ A cross-sectional study. World J Surg Oncol 2005;3:67.

Dogra A, Doval DC, Sardana M, Chedi SK, Mehta A. Clinic pathological characteristics of triple negative breast cancer at a tertiary care hospital in India. Asian Pac J Cancer Prev 2014;15:10577-83.

Reddy GM, Suresh PK, Pai RR. Clinic pathological features of triple negative breast carcinoma. J Clin Diagn Res 2017;11:EC05-8.

Adisa A, Arowolo O, Akinkuolie A, Alatise OI, Lawal OO, Adesunkanmi AK, et al. Metastatic breast cancer in a Nigerian tertiary hospital. Afr Health Sci 2011;11:279-284.

Saini VK, Sewal RK, Ahmad Y, Medhi B. Prospective observational study of adverse drug reactions of anticancer drugs used in cancer treatment in a tertiary care hospital. Indian J Pharm Sci 2015;77:687- 93.