EFFECT OF LABETALOL AND ESMOLOL ON ONSET OF ACTION OF ROCURONIUM: A PROSPECTIVE DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL

Ranjita Acharya; Shakti Bedanta Mishra; Arun Rath; Bhabani Sankara Pati; Kalyani Bala Nayak

doi:10.22159/ajpcr.2018.v11i6.23515

Authors

Ranjita Acharya Department of Anaesthesiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.
Shakti Bedanta Mishra Department of Anaesthesiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.
Arun Rath Department of Anaesthesiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.
Bhabani Sankara Pati Department of Anaesthesiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.
Kalyani Bala Nayak Department of Anaesthesiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i6.23515

Keywords:

Rocuronium, Muscle relaxation, Labetalol

Abstract

Objective: Labetalol is a non-selective beta blocker which is used for the treatment of hypertension. Its role in controlling the hemodynamic response to tracheal intubation is established. This comparative controlled study was carried out to verify its effects on time to onset of action of rocuronium in comparison to esmolol.

Methods: We randomized patients into two groups. Group A receiving injection labetalol 0.25 mg/kg diluted to 10 ml with 0.9% saline and Group B receiving 0.5 mg/kg of esmolol in 10 ml 0.9% saline before surgery. The time to onset of action of rocuronium, systolic blood pressure, and heart rate were recorded. The adverse reactions were observed in the post-operative period.

Results: A total of 60 patients were randomized into two groups. At the time of intubation, the systolic blood pressure and heart rate were similar between the two groups. The onset of action of rocuronium was decreased significantly in the labetalol group.

Conclusion: Labetalol attenuates the hemodynamic response to tracheal intubation both during intubation. It also slightly decreases the time to onset of action of rocuronium.

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Author Biographies

Ranjita Acharya, Department of Anaesthesiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

DEPARTMENT OF ANESTHESIOLOGY, ASSOCIATE PROFESSOR

Shakti Bedanta Mishra, Department of Anaesthesiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

Associate Professor department of anaesthesiology, IMS and SUM Hospital, Bhubaneswar, Odisha, India 751014

Arun Rath, Department of Anaesthesiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

Assistant Professor, IMS and SUM Hospital, Bhubaneswar, Odisha, India 751014

Bhabani Sankara Pati, Department of Anaesthesiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

Assistant Professor, IMS and SUM Hospital, Bhubaneswar, Odisha, India 751014

Kalyani Bala Nayak, Department of Anaesthesiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

Associate Professor, SCB Medical College and Hospital, Cuttack, Odisha, India 753007

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