ANTI-ULCER ACTIVITY OF AFRICAN LEAVES (VERNONIA AMYGDALINA DEL.) ETHANOL EXTRACT ON MALE RAT

Wahyudi; Edy Suwarso; Marline Nainggolan

doi:10.22159/ajpcr.2018.v11i3.23565

Authors

Wahyudi Department of Pharmacology, Faculty of Pharmacy.Indonesia
Edy Suwarso Department of Pharmacology, Faculty of Pharmacy.Indonesia
Marline Nainggolan Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i3.23565

Keywords:

African leaves, Peptic ulcer, Acetosal, Vernonia amygdalina Del

Abstract

Â Objectives: This study aims to evaluate the anti-ulcer activity of African leaves (Vernonia amygdalina Del.) ethanol extract on male rat.

Methods: African leaf powder was extracted used ethanol 96% by percolation, then made into a suspension preparation used 0.5% Na-CMC with 3 dose variations (100, 200 and 400 mg/kg). Further tested its effectiveness in healing peptic ulcer in gastric-induced rats using acetosal dose 800 mg/kg with oral administration every day until surgery at 3, 8, and 14. Observations include macroscopic (number and index of ulcer) and microscopic (histopathological test).

Results: A significant healing of ulcer was observed. The extract 100, 200, and 400 mg/kg group showed significant (p<0.05) reduction in number and index of ulcer as compared to the negative control. The most effective dose is 200 mg/kg because it has the greatest ability to reduce the number and index of ulcers and has the fastest recovery day.

Conclusion: Results of this study indicated that African leaves (V. amygdalina Del.) ethanol extract has potential anti-ulcer activity.

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