THE INVESTIGATION OF THE DEVELOPMENT OF A CREAM COMPOSITION WITH THE SAPROPEL EXTRACT

Authors

  • Oksana Strus Department of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
  • Natalya Polovko Department of Drug Technology, National University of Pharmacy, Kharkiv, Ukraine.
  • Yuliya Plaskonis Department of Pharmacy Management, Economics and Technology, SHEI I. Ya. Horbachevsky Тernopil State Medical University MPH of Ukraine”, Тernopil, Ukraine.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i7.23575

Keywords:

Sapropel, Sapropel extract, Emulsifying base, Investigation of the creamSapropel, Investigation of the cream

Abstract

Objective: The objective of this research was the development of cream with sapropel extract on the emulsifying base and the investigation of the possibility for cream samples to be in future applied in medicine, cosmetics, and veterinary.

Methods: To carry out the research a set of methods (centrifugal, thermal, and potentiometric) to analyze colloidal and thermal stability and determine pH values of the tested samples were used. Organoleptic characteristics of the tested samples and possible signs of physical instability were studied. Rheological properties of the samples were determined on the rotating viscometer. The method of microscopic analysis was carried out to analyze the stability of the emulsion system.

Results: The research outcomes revealed that all the prototype samples have thermal and colloid stability, neutral pH value, and consistency that depends on the content of the oil phase and the emulsifying mixture. The samples, containing 15% of Vaseline oil and 4% and 6% of emulsifier no. 1, have low viscosity indexes, and the sample with 10% of emulsifier has a rather dense consistency. The samples containing 20% of oil phase possess unsatisfactory organoleptic properties. Since the sample with 4% of emulsifier possessed low rates of viscosity and phase separation occurred during its storage.

Microscopic studies have shown that the sample containing 6% of emulsifier no. 1 exhibits monodisperse and a uniform roundness of drops that indicates the stability of the system.

Conclusion: The outcome of the research is the development of the composition of the cream with sapropel extract with the emulsifying base containing 15% of corn oil, 6% of emulsifier no. 1, and 1% of Cetostearyl alcohol and purified water.

Downloads

Download data is not yet available.

Author Biographies

Oksana Strus, Department of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

Department of drug technology and biopharmaceutics

Natalya Polovko, Department of Drug Technology, National University of Pharmacy, Kharkiv, Ukraine.

D.P. Salo Department of Drug Technology

Yuliya Plaskonis, Department of Pharmacy Management, Economics and Technology, SHEI I. Ya. Horbachevsky Тernopil State Medical University MPH of Ukraine”, Тernopil, Ukraine.

Department of Pharmacy Management, Economics and Technology

References

Konechna, et al. Research of antioxidant properties of extracts of the plants and the callus biomass. Asian J Pharm Clin Res 2017;10:182-5.

Eziuzo OS, Amarauche C. Studies on sida acuta hydrogel I: Processing and physicochemical properties of the derived hydrogel obtained from South East Nigeria. Int J Pharm Pharm Sci 2017;9;5-11.

Bhardwaj A, Modi KP. Pharmacognostical screening and determination of antioxidant activity of Nelumbo nucifera Gaertn ethanol seed extract by different in vitro models. Int J Pharm Pharm Sci 2017;9:64-70.

Strus OY. Study of sapropel extracts from Prybych natural deposits. J Chem Pharm Res 2015;7:133-7.

Strus OY. Prospects of the use of sapropel in medicine and cosmetology. Ukrainian J Сlin Lab Med 2014;2:28-37.

Strus OY. Investigation of carboxylic acids composition of sapropel by a chromato-mass spectroscopy method. Coll Sci Pap Staff Members P L Shupyk NMAPE 2015;24:228-33.

Strus OY. The study of amino acid composition of sapropel by capillary electrophoresis method. News Pharm 2015;2:12-6.

Strus OY. Analysis of extraction methods and improvement of sapropel extract’s technology, Coll Sci Pap Staff Members P L Shupyk NMAPE 2016;26:266-71.

Strus OY, Polovko NP. Modern State and Prospects of Sapropels use and their Preparations in Veterinary Practice Agrobiodiversity for Improving Nutrition, Health and Life Quality: Scientific Proceedings of the International Network AgroBioNet of the Institution and Researcher of International Research, Education and Development Programme «Agrobiodiversity for Improving Nutrition, Health and Life Quality». Part1; 2015. p. 633-6.

Strus OY, Polovko NP, Maloshtan LM, Yatsenko EY. Study of anti-inflammatory and reparative properties of sapropel extracts from Prybych deposits. Coll Sci Pap Staff Members P L Shupyk NMAPE 2014;23:392-8.

Strus OY, Polovko NP, Maloshtan LM, Osolodchenko TP. The research of the properties of sapropel from Prybych deposits. Ecol Med Gen Clin Immun 2014;3:169-73.

Strus OY, Geyderikh OG, Silaeva LF. The studies on development of the composition of masks with the sapropel paste. News Pharm 2016;3:51-3.

Nikam S. Anti-acne gel of Isotretinoin: Formulation and evaluation. Asian J Pharm Clin Res 2017;10:257-66.

Zandraa O, Saha N, Kitano T, Saha P. Properties of guar gum - dead sea salt (GG-DSS) medicated gel. Int J Pharm Pharm Sci 2015;7;226-32.

Yurchenko VY, Kovaleva TN, Polovko NP. Study of the development of emulsion bases for soft drug and cosmetic forms. Prob Ecol Med Gen Clin Immun 2012;114:440-6.

Kolesnikova V, Polovko NP. Justification of dermatological cream composition. Coll Sci Pap Staff Memb P L Shupyk NMAPE 2015;24:410-4.

Gubchenko TD. Development of the Composition and Technology of the Treatment-Cosmetic Cream with a Dense Extract of Walnut Leaves/ the Author’s Abstract of the Dissertation Ñand. Pharmacy Sciences: 15.00; 2008. p. 20, 14-5.

European Pharmacopoeia. European Pharmacopoeia. 8.0. Strasbourg: Council of Europe, European Directorate for the Quality of Medicines; 2013.

State Standard of Ukraine No. 4765:2007 Cosmetic Creams. General Technical Conditions. Kyiv, Ukraine: State Consumer Standard of Ukraine (In Ukr.); 2008. p. 12.

Published

07-07-2018

How to Cite

Strus, O., N. Polovko, and Y. Plaskonis. “THE INVESTIGATION OF THE DEVELOPMENT OF A CREAM COMPOSITION WITH THE SAPROPEL EXTRACT”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 7, July 2018, pp. 147-50, doi:10.22159/ajpcr.2018.v11i7.23575.

Issue

Section

Original Article(s)