NEUROCOGNITIVE STATUS IN INDONESIAN HIV-INFECTED REPRODUCTIVE WOMEN
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i10.24324Keywords:
Neurocognitive, HIV, AIDSAbstract
Introduction: HIV-associated neurocognitive disorder (HAND) was emerging with the deficits inclusion of psychomotor, memory, attention, and verbal fluency. This situation could increase the burden of an HIV-positive subject in daily activities, either the economic or social burden. However, the cases were more likely isolated without exact prevalence data.
Objective: This study aims to find the prevalence of HIV-HAND in Indonesia.
Methods: This was an analytical research with cross-sectional design to assess neurocognitive status in reproductive age mothers who took regular ARVs for more than 6 months. Neurocognitive impairment in AIDS is diagnosed with the International HIV dementia scale. Data were analyzed using SPSS 19.0
Results: In this study, no subjects were diagnosed with had neurocognitive impairment. Only 1 of 29 subjects (3.4%) with CD4>350/mm3 had slight psychomotor disorders.
Conclusion: This study showed that no subject with HIV infection in had dementia or neurocognitive impairment.
Downloads
References
Malini H. HIV/AIDS stigma and discrimination among the general public in selected rural community, Kancheepuram District, India. Asian J Pharm Clin Res 2006;9:132-5.
Velmurugan S, Ali MA, Kumar P. Micro particulate drug carries a promising approach for the development of anti-HIV drugs. Int J Pharm Pharmaceutic Sci 2014;6:21-39.
González-Scarano F, MartÃn-GarcÃa J. The neuropathogenesis of AIDS. Nat Rev Immunol 2005;5:69-81.
Gupta LK, Tripathi V. Chemokine receptors in HIV infection. Int J Pharm Pharmaceutic Sci 2012;4:69-72.
Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology 2007;69:1789-99.
Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: Differences in rates, nature, and predictors. J Neurovirol 2011;17:3-16.
Sacktor N, Skolasky RL, Seaberg E, Munro C, Becker JT, Martin E, et al. Prevalence of HIV-associated neurocognitive disorders in the multicenter AIDS cohort study. Neurology 2016;86:334-40.
Ances BM, Ellis RJ. Dementia and neurocognitive disorders due to HIV-1 infection. Semin Neurol 2007;27:86-92.
Alfahad TB, Nath A. Update on HIV-associated neurocognitive disorders. Curr Neurol Neurosci Rep 2013;13:387.
Arya A, Sindhwani G. A review on the neural circuits in anxiety disorder. Asian J Pharm Clin Res 2016;9:26-31.
Clifford DB, Ances BM. HIV-associated neurocognitive disorder. Lancet Infect Dis 2013;13:976-86.
Churchill MJ, Wesselingh SL, Cowley D, Pardo CA, McArthur JC, Brew BJ, et al. Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia. Ann Neurol 2009;66:253-8.
Chompre G, Cruz E, Maldonado L, Rivera-Amill V, Porter JT, Noel RJ Jr, et al. Astrocytic expression of HIV-1 nef impairs spatial and recognition memory. Neurobiol Dis 2013;49:128-36.
Wagner GA, Chaillon A, Liu S, Franklin DR Jr. Caballero G, Kosakovsky Pond SL, et al. HIV-associated neurocognitive disorder is associated with HIV-1 dual infection. AIDS 2016;30:2591-7.
Zipursky AR, Gogolishvili D, Rueda S, Brunetta J, Carvalhal A, McCombe JA, et al. Evaluation of brief screening tools for neurocognitive impairment in HIV/AIDS: A systematic review of the literature. AIDS 2013;27:2385-401.
Heaton RD, Franklin D, Woods S, Collier A, Clifford D, Gelman B, et al. The Charter Group Prevalence and Predictors of Neurocognitive Decline Over 18 to 42 Months: A Charter Longitudinal Study. 19th Conference on Retroviruses and Opportunistic Infections-Seattle. Western Australia; 2012. p. 246-8.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.