NEUROCOGNITIVE STATUS IN INDONESIAN HIV-INFECTED REPRODUCTIVE WOMEN

Authors

  • Sarma Nursani Lumbanraja Fetomaternal Division, Department of Obstetrics and Gynecology, H. Adam Malik General Hospital, University of Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i10.24324

Keywords:

Neurocognitive, HIV, AIDS

Abstract

Introduction: HIV-associated neurocognitive disorder (HAND) was emerging with the deficits inclusion of psychomotor, memory, attention, and verbal fluency. This situation could increase the burden of an HIV-positive subject in daily activities, either the economic or social burden. However, the cases were more likely isolated without exact prevalence data.

Objective: This study aims to find the prevalence of HIV-HAND in Indonesia.

Methods: This was an analytical research with cross-sectional design to assess neurocognitive status in reproductive age mothers who took regular ARVs for more than 6 months. Neurocognitive impairment in AIDS is diagnosed with the International HIV dementia scale. Data were analyzed using SPSS 19.0

Results: In this study, no subjects were diagnosed with had neurocognitive impairment. Only 1 of 29 subjects (3.4%) with CD4>350/mm3 had slight psychomotor disorders.

Conclusion: This study showed that no subject with HIV infection in had dementia or neurocognitive impairment.

Downloads

Download data is not yet available.

Author Biography

Sarma Nursani Lumbanraja, Fetomaternal Division, Department of Obstetrics and Gynecology, H. Adam Malik General Hospital, University of Sumatera Utara, Medan, Indonesia.

Associate professor

Department of Obstetrics and Gynaecology

Medical Faculty Universitas Sumatera Utara

Medan, Indonesia

References

Malini H. HIV/AIDS stigma and discrimination among the general public in selected rural community, Kancheepuram District, India. Asian J Pharm Clin Res 2006;9:132-5.

Velmurugan S, Ali MA, Kumar P. Micro particulate drug carries a promising approach for the development of anti-HIV drugs. Int J Pharm Pharmaceutic Sci 2014;6:21-39.

González-Scarano F, Martín-García J. The neuropathogenesis of AIDS. Nat Rev Immunol 2005;5:69-81.

Gupta LK, Tripathi V. Chemokine receptors in HIV infection. Int J Pharm Pharmaceutic Sci 2012;4:69-72.

Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology 2007;69:1789-99.

Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: Differences in rates, nature, and predictors. J Neurovirol 2011;17:3-16.

Sacktor N, Skolasky RL, Seaberg E, Munro C, Becker JT, Martin E, et al. Prevalence of HIV-associated neurocognitive disorders in the multicenter AIDS cohort study. Neurology 2016;86:334-40.

Ances BM, Ellis RJ. Dementia and neurocognitive disorders due to HIV-1 infection. Semin Neurol 2007;27:86-92.

Alfahad TB, Nath A. Update on HIV-associated neurocognitive disorders. Curr Neurol Neurosci Rep 2013;13:387.

Arya A, Sindhwani G. A review on the neural circuits in anxiety disorder. Asian J Pharm Clin Res 2016;9:26-31.

Clifford DB, Ances BM. HIV-associated neurocognitive disorder. Lancet Infect Dis 2013;13:976-86.

Churchill MJ, Wesselingh SL, Cowley D, Pardo CA, McArthur JC, Brew BJ, et al. Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia. Ann Neurol 2009;66:253-8.

Chompre G, Cruz E, Maldonado L, Rivera-Amill V, Porter JT, Noel RJ Jr, et al. Astrocytic expression of HIV-1 nef impairs spatial and recognition memory. Neurobiol Dis 2013;49:128-36.

Wagner GA, Chaillon A, Liu S, Franklin DR Jr. Caballero G, Kosakovsky Pond SL, et al. HIV-associated neurocognitive disorder is associated with HIV-1 dual infection. AIDS 2016;30:2591-7.

Zipursky AR, Gogolishvili D, Rueda S, Brunetta J, Carvalhal A, McCombe JA, et al. Evaluation of brief screening tools for neurocognitive impairment in HIV/AIDS: A systematic review of the literature. AIDS 2013;27:2385-401.

Heaton RD, Franklin D, Woods S, Collier A, Clifford D, Gelman B, et al. The Charter Group Prevalence and Predictors of Neurocognitive Decline Over 18 to 42 Months: A Charter Longitudinal Study. 19th Conference on Retroviruses and Opportunistic Infections-Seattle. Western Australia; 2012. p. 246-8.

Published

07-10-2018

How to Cite

Lumbanraja, S. N. “NEUROCOGNITIVE STATUS IN INDONESIAN HIV-INFECTED REPRODUCTIVE WOMEN”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 10, Oct. 2018, pp. 285-7, doi:10.22159/ajpcr.2018.v11i10.24324.

Issue

Section

Original Article(s)