MEDICINAL PLANTS AS POTENTIAL SOURCE OF ANTIOXIDANT AGENTS: A REVIEW
Keywords:Antioxidants, Free radicals, Medicinal plants, Phytochemicals
All over the world, the recent scientific studies revealed the medicinal properties of plants, which have been examined, because of their effective pharmacological activities, economic viability, and their low toxicity. Reactive oxygen species (ROS) enhancement by endogenous and exogenous stimuli can modify redox circumstances of normal cells. To balance ROS-mediated cellular damage, endogenous antioxidants' protection system subsists; however, when oxidation surpasses the control mechanisms, oxidative stress increases. Detrimental alterations induced in a variety of biomolecules such as proteins, lipids, and DNA which causes chronic escalation of oxidative stresses, which ultimately causes tissue damage and results in numerous diseases. Antioxidants reduce the effects of ROS and help us in the prevention of such diseases. Antioxidants can either be natural or synthetic. Natural antioxidants can be obtained through diet in the form of fruits, spices, vegetables, etc. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole also diminish oxidation, but they have been proved to be dangerous to humankind; therefore, investigation for non-toxic antioxidants has increased in the recent years.
Embuscado ME. Spices and herbs: Natural sources of antioxidantsâ€“a mini review. J Funct Foods 2015;18:811-9.
Haworth JE. Natural Antioxidants Review. In: Proceedings of the 56th Reciprocal Meats Conference; 2003. p. 95-8.
Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci 2004;74:2157-84.
Patil SM, Kadam VJ, Ghosh R. In vitro antioxidant activity of methanolic extract of stem bark of Gmelina arborea Roxb. (Verbenaceae). Int J Pharm Tech Res 2009;1:1408-84.
Subedi L, Timalsena S, Duwadi P, Thapa R, Paudel A, Parajuli K, et al. Antioxidant activity and phenol and flavonoid contents of eight medicinal plants from western Nepal. J Tradit Chin Med 2014;34:584- 90.
KÃ¶ksal E, Bursal E, GÃ¼lÃ§in Ä°, Korkmaz M, Ã‡aÄŸlayan C, GÃ¶ren AC, et al. Antioxidant activity and polyphenol content of Turkish thyme (Thymus vulgaris) monitored by liquid chromatography and tandem mass spectrometry. Int J Food Properties 2017;20:514-25.
Krishnaiah D, Sarbatly R, Nithyanandam R. A review of the antioxidant potential of medicinal plant species. Food Bioprod Process 2011;89:217- 33.
Leaves L. Antioxidant activity by DPPH radical scavenging method of ageratum conyzoides. Am J Ethnomed 2014;1:244-9.
de FÃ¡tima A, Modolo LV, Conegero LS, Pilli RA, Ferreira CV, Kohn LK, et al. Styryl lactones and their derivatives: Biological activities, mechanisms of action and potential leads for drug design. Curr Med Chem 2006;13:3371-84.
Shahidi F, McDonald J, Chandrasekara A, Zhong Y. Phytochemicals of foods, beverages and fruit vinegars: Chemistry and health effects. Asia Pac J Clin Nutr 2008;17 Suppl 1:380-2.
Auddy B, Ferreira M, Blasina F, Lafon L, Arredondo F, Dajas F, et al. Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases. J Ethnopharmacol 2003;84:131-8.
Samuelson G. Drugs of Natural Origin: A Textbook of Pharmacognosy. 4th ed. Stockholm: Swedish Pharmaceutical Press; 1999.
Craig WJ. Health-promoting properties of common herbs. Am J Clin Nutr 1999;70:491S-499S.
Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010;4:118-26.
Chung KT, Wong TY, Wei CI, Huang YW, Lin Y. Tannins and human health: A review. Crit Rev Food Sci Nutr 1998;38:421-64.
Hatano T, Kagawa H, Yasuhara T, Okuda T. Two new flavonoids and other constituents in licorice root: Their relative astringency and radical scavenging effects. Chem Pharm Bull (Tokyo) 1988;36:2090-7.
Benzie IF, Szeto YT. Total antioxidant capacity of teas by the ferric reducing/antioxidant power assay. J Agric Food Chem 1999;47:633-6.
Silva EM, Souza JN, Rogez H, Rees JF, Larondelle Y. Antioxidant activities and polyphenolic contents of fifteen selected plant species from the Amazonian region. Food Chem 2007;101:1012-8.
Leontowicz H, Gorinstein S, Lojek A, Leontowicz M, Ci;z M, Soliva-Fortuny R, et al. Comparative content of some bioactive compounds in apples, peaches and pears and their influence on lipids and antioxidant capacity in rats. J Nutr Biochem 2002;13:603-10.
Ramos A, Rivero R, Victoria MC, Visozo A, Piloto J, GarcÃa A, et al. Assessment of mutagenicity in Parthenium hysterophorus L. J Ethnopharmacol 2001;77:25-30.
Kirby AJ, Schmidt RJ. The antioxidant activity of Chinese herbs for eczema and of placebo herbsâ€”I. J Ethnopharmacol 1997;56:103-8.
Rice-Evans C, Miller NJ. 241 Total antioxidant status in plasma and body fluids. Methods Enzymol 1994;234:279-93.
BaltruÅ¡aitytÄ— V, Venskutonis PR, ÄŒeksterytÄ— V. Radical scavenging activity of different floral origin honey and beebread phenolic extracts. Food Chem 2007;101:502-14.
Halliwell B, Gutteridge JM, Aruoma OI. The deoxyribose method: A simple test-tubeâ€ assay for determination of rate constants for reactions of hydroxyl radicals. Analy Biochem 1987;165:215-9.
Jodynis-Liebert J, Murias M, BÅ‚oszyk E. Effect of several sesquiterpene lactones on lipid peroxidation and glutathione level. Planta Med 1999;65:320-4.
Oyaizu M. Studies on product of browing effect reaction prepared from glucose amine. J Nutr 1986;44:307-15.
Mackeen MM, Ali AM, Lajis NH, Kawazu K, Hassan Z, Amran M, et al. Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis griff. Ex T. Anders. J Ethnopharmacol 2000;72:395-402.
Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 1965;16:144-58.
Bartley JP, Jacobs AL. Effects of drying on flavour compounds in Australian-grown ginger (Zingiber officinale). J Sci Food Agric 2000;80:209-15.
Peter KV, editor. Handbook of Herbs and Spices. Cambridge: Woodhead Publishing; 2006. p. 25.
Baliga MS, Haniadka R, Pereira MM, Dâ€™Souza JJ, Pallaty PL, Bhat HP, et al. Update on the chemopreventive effects of ginger and its phytochemicals. Crit Rev Food Sci Nutr 2011;51:499-523.
Surh YJ, Park KK, Chun KS, Lee LJ, Lee E, Lee SS, et al. Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger. J Environ Pathol Toxicol Oncol 1999;18:131-9.
Akinyemi AJ, Ademiluyi AO, Oboh G. Aqueous extracts of two varieties of ginger (Zingiber officinale) inhibit angiotensin Iâ€“converting enzyme, iron (II), and sodium nitroprusside-induced lipid peroxidation in the rat heart in vitro. J Med Food 2013;16:641-6.
Kazeem MI, Akanji MA, Yakubu MT. Amelioration of pancreatic and renal derangements in streptozotocin-induced diabetic rats by polyphenol extracts of ginger (Zingiber officinale) rhizome. Pathophysiology 2015;22:203-9.
Kazeem MI, Akanji MA, Hafizur RM, Choudhary MI. Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria. Asian Pac J Trop Biomed 2012;2:727-32.
Mahmoud MF, Diaai AA, Ahmed F. Evaluation of the efficacy of ginger, Arabic gum, and Boswellia in acute and chronic renal failure. Ren Fail 2012;34:73-82.
Srinivasan K. Ginger rhizomes (Zingiber officinale): A spice with multiple health beneficial potentials. Pharma Nutr 2017;5:18-28.
Nagendra chari KL, Manasa D, Srinivas P, Sowbhagya HB. Enzyme-assisted extraction of bioactive compounds from ginger (Zingiber officinale roscoe). Food Chem 2013;139:509-14.
Srinivasan K. Antioxidant potential of spices and their active constituents. Crit Rev Food Sci Nutr 2014;54:352-72.
Surh Y. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat Res 1999;428:305- 27.
Stoilova I, Krastanov A, Stoyanova A, Denev P, Gargova S. Antioxidant activity of a ginger extract (Zingiber officinale). Food Chem 2007;102:764-70.
Aeschbach R, LÃ¶liger J, Scott BC, Murcia A, Butler J, Halliwell B, et al. Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem Toxicol 1994;32:31-6.
Ippoushi K, Azuma K, Ito H, Horie H, Higashio H. -gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life Sci 2003;73:3427-37.
Abd El Sattar El Batran S, El-Gengaihi SE, El Shabrawy OA. Some toxicological studies of Momordica charantia L. On albino rats in normal and alloxan diabetic rats. J Ethnopharmacol 2006;108:236-42.
Saeed MK, Shahzadi I, Ahmad I, Ahmad R, Shahzad K, Ashraf M, et al. Nutritional analysis and antioxidant activity of bitter gourd (Momordica charantia) from Pakistan. Pharmacol Online 2010;1:252-60.
Sridhar MG, Vinayagamoorthi R, Suyambunathan VA, Bobby Z, Selvaraj N. Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats. Br J Nutr 2008;99:806- 12.
Shih CC, Lin CH, Lin WL. Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet. Diabetes Res Clin Pract 2008;81:134-43.
Wu SJ, Ng LT. Antioxidant and free radical scavenging activities of wild bitter melon (Momordica charantia Linn. Var. Abbreviata Ser.) in Taiwan. LWT Food Sci Technol 2008;41:323-30.
Carlini EA, Contar J de DP, Silva-Filho AR, da Silveira-Filho NG, Frochtengarten ML, Bueno OF, et al. Pharmacology of lemongrass (Cymbopogon citratus stapf). I. Effects of teas prepared from the leaves on laboratory animals. J Ethnopharmacol 1986;17:37-64.
Jamuna S, Sadullah S, Ashokkumar R, Shanmuganathan G, Mozhi SS. Potential antioxidant and cytoprotective effects of essential oil extracted from Cymbopogon citratus on OxLDL and H2O2 LDL induced human peripheral blood mononuclear cells (PBMC). Food Sci Hum Wellness 2017;6:60-9.
Cheel J, Theoduloz C, RodrÃguez J, Schmeda-Hirschmann G. Free radical scavengers and antioxidants from lemongrass (Cymbopogon citratus (DC.) stapf.). J Agric Food Chem 2005;53:2511-7.
Al-Snafi AE. The chemical constituents and pharmacological effects of Adiantum capillus-veneris - A review. Asian J Pharm Sci Technol 2015;5:106-11.
Rajurkar NS, Gaikwad K. Evaluation of phytochemicals, antioxidant activity and elemental content of Adiantum capillus veneris leaves. J C Pharm Res 2012;4:365-74.
Jiang MZ, Yan H, Wen Y, Li XM. In vitro and in vivo studies of antioxidant activities of flavonoids from Adiantum capillus-veneris L. Afr J Pharm Pharmacol 2011;5:2079-85.
Goenadi DH. Water Tension and Fertilization of Stevia rebaudiana Bertoni on Oxidropudalf soil. Menara perkebunan, Horticulture Abstracts; 1983;54:2882.
Geuns JM. Safety of Stevia and stevioside. Recent Res Dev Phytochem 2000;4:75-88.
Suanarunsawat T, Chaiyabutr N. The effect of stevioside on glucose metabolism in rat. Can J Physiol Pharmacol 1997;75:976-82.
Chan P, Tomlinson B, Chen YJ, Liu JC, Hsieh MH, Cheng JT. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharm 2000;50:215- 20.
Shukla S, Mehta A, Mehta P, Bajpai VK. Antioxidant ability and total phenolic content of aqueous leaf extract of Stevia rebaudiana bert. Exp Toxicol Pathol 2012;64:807-11.
Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: Renal effects. J Ethnopharmacol 1995;47:129-34.
Parrotta JA. Healing Plants of Peninsular India. New York: CABI Publishing; 2001.
Al-Snafi AE. Medical importance of Datura fastuosa (syn: Datura metel) and Datura stramonium - A review. IOSR J Pharm 2017;7:43- 58.
Dhiman A, La R, Bhan M, Dhiman B, Hooda A. Plebeian assessment of anti-microbial and in vitro antioxidant zest of D. fastuosa L. Seeds. J Pharm Sci Innov 2012;1:49-53.
Sangeetha S, Deepa M, Sugitha N, Mythili S, Sathiavelu A. Antioxidant activity and phytochemical analysis of Datura metel. Int J Drug Dev Res 2014;6:4.
Sharififar F, Dehghn-Nudeh G, Mirtajaldini M. Major flavonoids with antioxidant activity from Teucrium polium L. Food Chem 2009;112:885-8.
Hasani P, Yasa N, Vosough-Ghanbari S, Mohammadirad A, Dehghan G, Abdollahi M. In vivo antioxidant potential of Teucrium polium, as compared to Î±-tocopherol. Acta Pharm 2007;57:123-9.
Ljubuncic P, Dakwar S, Portnaya I, Cogan U, Azaizeh H, Bomzon A, et al. Aqueous extracts of Teucrium polium possess remarkable antioxidant activity in vitro. Evid Based Complement Alternat Med 2006;3:329-38.
Padma P, Chansauria JP, Khosa RL, Ray AK. Effect of Annooa muricata and Polyalthia cerasoides on brain neurotransimitters and enzyme monoamine oxidase following cold immobilization stress. J Nat Remedies 2001;1:144-6.
Cousins D, Huffman MA. Medicinal properties in the diet of gorillas: An ethno-pharmacological evaluation. Afr Study Monogr 2002;23:65- 89.
Ravikumar YS, Mahadevan KM, Kumaraswamy MN, Vaidya VP, Manjunatha H, Kumar V, et al. Antioxidant, cytotoxic and genotoxic evaluation of alcoholic extract of Polyalthia cerasoides (Roxb.) bedd. Environ Toxicol Pharmacol 2008;26:142-6.
Kakouri E, Daferera D, Paramithiotis S, Astraka K, Drosinos EH, Polissiou MG. Crocus sativus L. Tepals: The natural source of antioxidant and antimicrobial factors. J Appl Res Med Aromat Plants 2017;4:66-74.
Bulus T, David SI, Bilbis LS, Babando A. In vitro antioxidant activity of n-butanol extract of Curcuma longa and its potential to protect erythrocytes membrane against osmotic-induced haemolysis. Sci World J 2017;12:13-7.
Pandey G, Verma KK, Singh M. Evaluation of phytochemical, antibacterial and free radical scavenging properties of Azadirachta indica (neem) leaves. Int J Pharm Pharm Sci 2014;6:444-7.
Yanpallewar SU, Rai S, Kumar M, Acharya SB. Evaluation of antioxidant and neuroprotective effect of Ocimum sanctum on transient cerebral ischemia and long-term cerebral hypoperfusion. Pharmacol Biochem Behav 2004;79:155-64.
Basu T, Panja S, Ghate NB, Chaudhuri D, Mandal N. Antioxidant and antiproliferative effects of different solvent fractions from Terminalia belerica roxb. Fruit on various cancer cells. Cytotechnology 2017;69:201-16.
Bontempo P, Carafa V, Grassi R, Basile A, Tenore GC, Formisano C, et al. Antioxidant, antimicrobial and anti-proliferative activities of Solanum tuberosum L. Var. Vitelotte. Food Chem Toxicol 2013;55:304-12.
Abdellaoui M, Kasrati A, El Rhaffari L. The effect of domestication on seed yield, essential oil yield and antioxidant activities of fennel seed (Foeniculum vulgare Mill) grown in Moroccan oasis. J Assoc Arab Univ Basic Appl Sci 2017;24:107-14.
Vijikumar S. Cuscuta reflexa Roxb.â€“A wonderful miracle plant in ethnomedicine. Indian J Nat Sci 2011;976:997.
Li Y, Liu H, Han Q, Kong B, Liu Q. Cooperative antioxidative effects of zein hydrolysates with sage (Salvia officinalis) extract in a liposome system. Food Chem 2017;222:74-83.
Arunodaya HS, Krishna V, Shashikumar R, Kumar KG. Antibacterial and antioxidant activities of stem bark essential oil constituents of Litsea glutinosa Cb Rob. Int J Pharm Pharm Sci 2016;8:258-64.
Aju BY, Rajalakshmi R, Mini S. Evaluation of antioxidant activity of Murraya koenigii (L.) Spreng using different in vitro methods. J Pharm Phytochem 2017;6:939-42.
Heer A, Guleria S, Razdan VK. Chemical composition, antioxidant and antimicrobial activities and characterization of bioactive compounds from essential oil of Cinnamomum tamala grown in north-western Himalaya. J Plant Biochem Biotechnol 2017;26:191-8.
Kim S, Kim DB, Jin W, Park J, Yoon W, Lee Y, et al. Comparative studies of bioactive organosulphur compounds and antioxidant activities in garlic (Allium sativum L.), elephant garlic (Allium ampeloprasum L.) and onion (Allium cepa L.). Nat Prod Res 2017;32(10):1193-7.
Prejeena V, Suresh SN, Varsha V. Phytochemical screening, antioxidant analysis and antiproliferative effect of Costus pictus d. Don leaf extracts. Int J Recent Adv Multidiscip Res 2017;4:2373-8.
Verma M, Kumar A. Antimicrobial and antioxidant activity of whole plant extracts of Bacopa monnieri (l.) pennell. Int J Appl Biol Pharm Tech 2017;8:73.
Amakura Y, Yoshimura A, Yoshimura M, Yoshida T. Isolation and characterization of phenolic antioxidants from Plantago herb. Molecules 2012;17:5459-66.
Ganie SA, Dar TA, Hamid R, Zargar O, Ul Abeer S, Masood A, et al. In vitro antioxidant and cytotoxic activities of Arnebia benthamii (Wall ex. G. Don): A critically endangered medicinal plant of Kashmir valley. Oxid Med Cell Longev 2014;2014:792574.
LÃ³pez Z, NÃºÃ±ez-Jinez G, Avalos-Navarro G, Rivera G, Salazar-Flores J, RamÃrez JA, et al. Antioxidant and cytotoxicological effects of Aloe vera food supplements. J Food Qual 2017. Article ID: 7636237, 10 Page.
Shyamala BN Jr., Jamuna P. Nutritional content and antioxidant properties of pulp waste from Daucus carota and beta vulgaris. Malays J Nutr 2010;16:397-408.
Jain S, Jain DK, Balekar N. Inâ€“vivo Antioxidant activity of ethanolic extract of Mentha pulegium leaf against CCl4 induced toxicity in rats. Asian Pac J Trop Biomed 2012;2:S737-40.
KaragÃ¶z A, Artun FT, Ã–zcan G, MelikoÄŸlu G, AnÄ±l S, KÃ¼ltÃ¼r Åž, et al. In vitro evaluation of antioxidant activity of some plant methanol extracts. Biotechnol Biotechnol Equip 2015;29:1184-9.
Fatima Z, Abderrahmane B, Seddik K, Lekhmici A. Antioxidant activity assessment of Tamus communis L. roots. Int J Pharm Pharm Sci 2016;8:64-71.
Abdallah IZ, Ibrahim SS, El-Salam A, Nayrouz AS. Evaluation of antidiabetic and antioxidant activity of Aegle marmelos L. correa fruit extract in the diabetic Rats. Egypt J Hosp Med 2017;67:731-41.
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