THERMOGRAVIMETRIC STUDIES OF NASAL GEL WITH DRY EXTRACT OF LICORICE ROOT AND ESSENTIAL OILS
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i8.24948Keywords:
Thermogravimetric studies, Nasal gel, Dry extract of licorice root, Essential oilsAbstract
Objectives: The objectives of this study were to conduct thermogravimetric (TG) studies of nasal gel with dry extract of licorice root and essential oils for the treatment of viral rhinitis.
Methods: TG analysis performs on the derivative Q-1000 of the system F. Paulik, I. Paulik, and L. Efdei with platinum-based thermocouple. Then the curves T (temperature changes), TG (changes in weight), DTA (differentiated curve of thermal effects), DTG (differentiated weight change curve) were recorded. As an inert material, the standard is usually aluminum oxide, which should not undergo transformations with the release or absorption of heat in the temperature range under study. The temperature difference of the sample and the standard is determined by the differential thermocouple. The samples were heated in ceramic crucibles from 18 to 500°C in the air. The heating rate was 5°C in min. The weight of the samples was 50 mg.
Results: In analyzing the derivatograms of all samples, it was found that the developed nasal dosage form of natural raw compounds on the base of carbomer gel is a mechanical mixture of active ingredients and excipients since its ingredients do not interact with each other.
The production of nasal gel with dry extract of licorice root and essential oils of Siberian pine and eucalyptus at temperatures taken in the process of carbomer gel (room temperature) does not lead to destruction of the components of investigated dosage form.
Conclusion: The developed nasal dosage form of natural raw compounds on the base of carbomer gel is a mechanical mixture of active ingredients and excipients since its ingredients do not interact with each other. The production of nasal gel with dry extract of licorice root and essential oils of Siberian pine and eucalyptus at temperatures taken in the process of carbomer gel (room temperature) does not lead to the destruction of the components of investigated dosage form.
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