A SYSTEMATIC REVIEW OF TRADITIONAL USES BIOACTIVE PHYTOCONSTITUENTS OF GENUS EHRETIA
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i6.25178Keywords:
Ehretia, Traditional and medicinal importance, Essential oil, Antiparasitic activity, Future prospectsAbstract
 The plants of the genus Ehretia composed of about 150 species mainly distributed in tropical Asia, Africa, Australia, and North America. They have been used as traditional and folk medicines to treat various ailments in Japan, India, and China for a long time. Previous phytochemical screenings demonstrated that the Ehretia plants mainly contain fatty acids, phenolic acids, flavonoids, cyanogenetic glycosides, and benzoquinones and other constituents from different chemical classes. The pharmacological studies confirmed that the crude extracts or individual compounds from the genus showed antioxidant, anti-inflammatory, antibacterial, antiarthritic, antitubercular, and antiallergic activities, as well as anti-snake venom property. In this review, we presented a summary of the secondary metabolites isolated from different species of Ehretia based on the published literatures up to March 2017. In addition to the traditional medicinal use of Ehretia plants, we focused on the known biological activities of the plants and discussed them in detail here.
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References
Gottschling M, Hilger HH. Characterisation of a novel fruit type found in Ehretia (Ehretiaceae, Boraginales). Blumea 2004a;49:145-53.
Sahay SK. On the Pollen Morphology of Ehretiaceae with Reference to Taxonomy. IV Int. Palynol. Conf. 1979. p. 471-9.
Rabaey D, Lens F, Smets E Jansen S. The phylogenetic significance of vestured pits in Boraginaceae. Int Assoc Plant Taxonomy 2010;59:510-6.
Sultana A, Hussain MS, Rathore DK. Diversity of tree vegetation of Rajasthan, India. Trop Ecol 2014;55:403-10.
Mandal G, Joshi SP. Analysis of vegetation dynamics and phytodiversity from three dry deciduous forests of Doon Valley, Western Himalaya, India. J Asia Pac Biodivers 2014a;7:292-304.
Gottschling M, Hilger HH. The systematic position of Ehretia cortesia nom. nov. (-Cortesia cuneifolia: Ehretiaceae, Boraginales) inferred from molecular and morphological data. Int Assoc Plant Taxonomy 2004b;53:919-23.
Hester AJ, Scogings PF, Trollope WS. Long-term impacts of goat browsing on bush-clump dynamics in a semi-arid subtropical savanna. Plant Ecol 2006;183:277-90.
Miller JS. Classification of Boraginaceae subfam. Ehretioideae : Resurrection of the genus Hilsenbergia Tausch ex Meisn. World 2003;25:151-89.
Forster PI. Ehretia grahamii (Boraginaceae): Notes on distribution, habitat, variation and conservation status. Queensland Herbarium 1995;4:451-2.
Gottschling M, Hilger HH. First fossil record of transfer cells in angiosperms. Am J Bot 2003;90:957-9.
Gurke M. Die Natürlichen Pflanzenfamilien. Vol. 4. Germany: W. Engelmann, Leipzig; 1893. p. 59-96.
Pimienta-Barrios E, Robles-Murguia C, Martinez-Chavez CC. Ecophysiological responses of native and exotic young trees to drought and rainfall. Rev Fitotecnia Mex 2012;35:15-20.
Retief E, Van Wyk AE. The genus Ehretia (Boraginaceae: Ehretioideae) In Southern Africa. Bothalia 2001;31:9-23.
Shu HK. Ehretia P. browne, Civ. nat. Hist. Jamaica 168. 1756. Flora of China. 1995;16:333-6.
Miller JS. Arevision of the new world species of Ehretia (Boraginaceae). Ann Mo Bot Gard 1989;76:1050-76.
Scott PE, Martin RF. Avian consumers of Bursera, Ficus, and Ehretia fruits in Yucatán. Biotropica 1984;16:319-23.
Joshi R, Singh R. Feeding behaviour of wild Asian elephants (elephas maximus) in the Rajaji National Park. J Am Sci 2008;4:34-48.
Bakshi MP, Wadhwa M. Evaluation of forest tree leaves of semi-hilly arid region as livestock feed. Asian Aust J Anim Sci 2004;17:777-83.
Tefera S, Mlambo V, Dlamini BJ, Dlamini AM, Koralagama KD, Mould FL. Chemical composition and in vitro ruminal fermentation of common tree forages in the semi-arid rangelands of Swaziland. Anim Feed Sci Technol 2008;142:99-110.
Bandyopadhyay S, Kr MS. Wild edible plant of Koch Bihar District, West Bengal. Natl Prod Radiance 2009;8:64-72.
Mandal G, Joshi SP. Quantitative vegetation dynamics and invasion success of lantana camara from the tropical forests of doon valley. Int J Conserv Sci 2014b;5:511-26.
Rao BH, Rao PSP. Embryology of three species of Ehretia. Proc Indian Acad Sci (Plant Sci.) 1984;93:57-65.
Li L, Li MH, Xu LJ, Guo N, Wu-Lan T, Shi R, et al. Distribution of seven polyphenols in several medicinal plants of Boraginaceae in China. J Med Plants Res 2010;4:1216-21.
Jeruto P, Mutai C, C. L, O. G. Phytochemical constituents of some medicinal plants. JAnim Plant Sci 2011;9:1201-10.
Li L, Peng Y, Yao X, Xu L, Wulan T, Liu Y, et al. Chemical constituents and biological activities of plants from the genus Ehretia Linn. Chinese Herb Med 2010;2:106-11.
Jain S, Srivastava S. Dictionary of Ethnoveterinary Plants of India. Dictionary of Ethnoveterinary Plants of India. New Delhi: Deep Publications; 1999. p. 218.
Wang WT. Flora Reipublicae Popularis Sinicae. Beijing: Science Press; 1979.
Choudhury S, Sharma P, Choudhury MD, Sharma GD. Ethnomedicinal plants used by Chorei tribes of Southern Assam, North Eastern India. Asian Pac J Trop Dis 2012;2:141-7
Wang YC, Huang TL. Screening of anti-helicobacter pylori herbs deriving from Taiwanese folk medicinal plants. FEMS Immunol Med Microbiol 2005;43:295-300.
Torane RC, Kamble GS, Kale AA, Gadkari TV, Deshpande NR. Quantification of dioctyl phthalate from Ehretia laevis Roxb by HPTLC. J Chem Pharm Res 2011a;3:48-51.
Torane RC, Kamble GS, Gadkari TV, Tambe AS, Deshpande NR. GC-MS study of nutritious leaves of Ehretia laevis. Int J ChemTech Res 2011;3:1589-91.
Sharma J, Gairola S, Sharma YP, Gaur RD. Ethnomedicinal plants used to treat skin diseases by Tharu community of district Udham Singh Nagar, Uttarakhand, India. J Ethnopharmacol 2014;158 Pt A:140-206.
Yamamura S, Simpol LR, Ozawa K, Ohtani K, Otsuka H, Kasai R, et al. Antiallergic dimeric prenylbenzoquinones from Ehretia microphylla. Phytochemistry 1995;39:105-10.
Iqbal K, Nawaz SA, Malik A, Riaz N, Mukhtar N, Mohammad P, Choudhary MI. Isolation and lipoxygenase-inhibition study of phenolic constituent from Ehretia obstifolia. Chem Biodiv 2005;2:104-11.
Ogundajo AL, Nnaemeka CO, Olawunmi RO, Ogunwande IA. Chemical Constituents of essential oil of Ehretia cymosa Thonn. Br J Appl Sci Technol 2016;14:1-6.
Sempombe J, Mugoyela V, Mihale MJ, Zacharia A, Ipagala P, Kilulya KF. Preliminary in vivo antitrypanosomal activity and cytotoxicity of Entada abyssinica, Securinega virosa and Ehretia amoena. East Central Afr J Pharm Sci 2014;17:37-43.
Yoshikawa K, Kageyama H, Arihara S. Phenolic glucosides and lignans from Ehretia ovalifolia. Phytochemistry 1995;39:659-64.
Li L, Xu LJ, He ZD, Yang QQ, Peng Y, Xiao PG. Chemical study on ethyl acetate portion of Ehretia thyrsiflora, Boraginaceae species of Ku-Ding-Cha. China J Chinese Mater Med 2008;17:2121-3.
Li L, Peng Y, Xu LJ, Li MH, Xiao PG. Flavonoid glycosides and phenolic acids from Ehretia thyrsiflora. Biochem Syst Ecol 2009a;36:915-8.
Khattab AM, Grace MH, El-Khrisy EA. ChemInform abstract: A new flavone derivative from Ehretia ovalifolia leaves. Pharmazie 2001;56:661-2.
Suri OP, Jamwal RS, Suri KA, Atal CT. Ehretinine, a novel pyrrolizidine alkaloid from Ehretia aspera. Phytochemistry 1980;19:1273-4.
Li L, Studies on Quality Control of Small Leaves Ku-Ding-Cha and Preliminary Pharmacophylogeny on Boraginaceae Ku-Ding-Cha. Ph.D. Dissertion, Peking Union Medical College, Beijing; 2009.
Dong M, Oda Y, Hirota M. (10E,12Z,15Z)-9-hydroxy-10,12,15- octadecatrienoic acid methyl ester as an anti-inflammatory compound from Ehretia dicksonii. Biosci Biotechnol Biochem 2000;64:882-6.
Selvanayagam ZE, Gnanavendhan SG, Balakrishna K, Rao RB, Sivaraman J, Subramanian K, et al. Ehretianone, a novel quinonoid xanthene from Ehretia buxifolia with antisnake venom activity. J Natl Prod 1996;59:664-7.
Agarwal SK, Rastogi RP, Van Koningsveld H, Goubitz K, Olthof GJ. The molecular structure of 4a, 5, 8, 8a-tetrahydro-11,14-dimethoxy-7- methyl-4a-(3-methyl-2-butenyl)-5,8a-O-benzeno-1,4-naphthoquinone. Tetrahedron 1980;36:1435-8.
Thapliyal PC, Yadav SK. A new naphthoquinone from aerial parts of Ehretia laevis. J Inst Chem India 2003;75:13-5.
Chien Y, Lin C, Chiang MY, Chang H, Liao C, Chen I, et al. Secondary metabolites from the root of Ehretia longiflora and their biological activities. Phytochemistry 2012;80:50-7.
Simpol LR, Otsuka H, Ohtani K, Kasai R, Yamasaki K. Nitrile glucosides and rosmarinic acid, the histamine inhibitor from Ehretia philippinensis. Phytochemistry 1994;36:91-5.
Dan S, Dan SS. Triterpenoids of the bark of Ehretia laevis. Fitoterapia 1982;53:51-2.
Li L, Tu YH, Xu LJ, Ma P, Peng Y, Wu QL, et al. Antioxidant activities and identification of the polyphenol characters by HPLC/UV/MS on Ehretia thyrsiflora. Natl Prod Res Dev 2009b;21:360-4.
Torane RC. In-vitro antioxidative activity of phenolic and flavonoid contents of leaves of medicinal plant–Ehretia laevis. Int J Pharm Biosci 2011;2:810-5.
Saad R, Asmani F, Saad M, Hussain M, Khan J, Kaleemullah M, et al. A new approach for predicting antioxidant property of herbal extracts. Int J Pharm Phytochem Res 2015;7:166-74.
Saman Z, Dildar A, Hira B, Muhammad I. Evaluation of antioxidant activities of various solvent extracts of fruits and leaves of Ehretia serrata. Asian J Chem 2012;24:4345-435.
Sivasankar V, Revathi P, Parimelazhagan T. Evaluation of in vitro antioxidant activity in edible fruits of Ehretia laevis Roxb. Int J Pharm Bio Sci 2013;4:847-57.
Juan FP, Sylvia PD, Mercedes GL, Julio M, Gabriela L, Francisco D. Physicochemical, nutritional and antioxidant characteristics of the fruit of Ehretia tinifolia. Rev Mex Biodiv 2012;83:273-80.
Palaniappan R, Senguttuvan J, Kandasamy P, Subramaniam P. In vitro antioxidant properties of the traditional medicinal plant species, Ehretia microphylla Lam. and Erythroxylon monogynum Roxb. Res J Pharm Biol Chem Sci 2014;5:247-52.
Jyothirmai N, Nagaraju B, Deepika MY, Kumar JN, Rani GS. Evaluation of anti-inflammatory and anti-bacterial activities of different solvent extracts of Ehretia laevis Roxb. J Pharm Sci Res 2016;8:715-20.
Rimando AM, Inoshiri S, Otsuka H, Kohda H, Yamasaki K, Padolina WG, et al. Screening for mast cell histamine release inhibitory activity of Philippine medicinal plants. Active constituent of Ehretia microphylla. Japanese J Pharmacog 1987;41:242-7.
Deshpande R, Kamath A, Chaturvedi S, Mutha MM, Shep S, Torane R, et al. Comparative evaluation of antimicrobial properties of different extracts of ‘Ehretia laevis’ against salivary microflora. Res J Pharm Biol Chem Sci 2014;5:489.
Gumgumjee NM, Hajar AS. Antibacterial activities and gc-ms analysis of phytocomponents of Ehretia abyssinica R.Br. Ex Fresen. Int J Appl Biol Pharm Technol 2015;6:236-41.
Demetrio LV, Jeannie IA, Juliana JM, Esperanza CC, Windell LR. Antibacterial activities of ethanol extracts of Philippine medicinal plants against multidrug-resistant bacteria. Asian Pac J Trop Biomed 2015;5:532-40.
Velappan S, Thangaraj P. Phytochemical constituents and antiarthritic activity of Ehretia laevis Roxb. J Food Biochem 2013;38:433-43.
Freiburghaus F, Ogwal EN, Nkunya MH, Kaminsky R, Brun R. In vitro antitrypanosomal activity of African plants used in traditional medicine in Uganda to treat sleeping sickness. Trop Med Int Health 1996;1:765-71.
Joshi B, Hendrickx S, Magar LB, Parajuli N, Dorny P, Maes L. In vitro antileishmanial and antimalarial activity of selected plants of Nepal. J Intercult Ethnopharmacol 2016;5:383-9.
Mohiuddin M, Arbain D, Islam AK, Rahman M, Ahmad MS, Ahmad MN. Electrochemical measurement of the antidiabetic potential of medicinal plants using multi-walled carbon nanotubes paste electrode. Russ J Electrochem 2015;51:368-75.
Venkata PK, Prameela RA, Pooja B, Anil KY. Phytochemical screening, spectroscpic characterisation and cardiotonic activity of aqueous extract from arieal parts of Carmona retusa (Vahl) masam on isolated frogs heart. Int J Pharm Chem 2016;6:231-6.
Shaoyong Y, Fan D, Ruinian L, Dan Z, Zhaoqiang H. A new species of Ehretia, Ehretia retroserrata in Nujiang County, Yunnan Province, China. Am J Plant Sci 2015;6:260-3.
Aarthi V, Anbu J, Ahamed KF, Anjana A, Velpandian V. Effect of Ehretia microphylla lamk on stimulation of reproductive function and ovarian folliculogenesis in rats. Int J Pharm Biosci 2012;3:273-80
A.H., M., S., H., R., J., M., R. Some medicinal plants used in Bangladesh in traditional medicinal treatment of various forms of cancer. Planta Med 2009;75:1537-4170. Mageswari S, Karpagam S, Reddy GA. Evaluation of wound healing activity of the plant Carmona retusa (Vahl.) Masam., in mice. Int J Integr Sci Innov Technol 2015;4:1-4.
Quintana E, Saludez J, Batoon M, Generalao M. Agricultural production of selected medicinal plants: Propagation to postharvest handling. Philipp Counc Agric Resour Res Dev 1982;10:8-10.
Chakraborty M, Bhattacharjee A. A Plants used as masticatories by the ethnic communities of Purulia District, West Bengal, India. J Econ Taxonomic Bot 2003;27:568-70.
Shah A, Rahim S. Ethnomedicinal uses of plants for the treatment of malaria in Soon Valley, Khushab, Pakistan. J Ethnopharmacol 2017;200:84-106.
Airi S, Rawal R, Samant S, Dhar U. Treatments to improve germination of four multipurpose trees of central sub Himalaya. Seed Sci Technol 1998;26:347-54.
Gottschling M, Luebert F, Hilger HH, Miller JS. Molecular delimitations in the ehretiaceae (boraginales). Mol Phylogenet Evol 2014;72:1-6.
Dzib-Guerra W del C, Escalante-Erosa F, Garcia-Sosa K, Derbre S, Blanchard P, Richomme P, Pena-Rodriguez L. Anti-Advanced glycation end-product and free radical scavenging activity of plants from the yucatecan flora. Pharmacog Res 2016;8:276.
Thakre R, Bhutada S, Chouragade B, Khobragade P, Harne K. Unexplored wound healing property of Ehretia leavis Roxb. (Khandu chakka) plant. Int J Res Ayurveda Pharm 2016;7:54-7.
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