FORMULATION AND CHARACTERIZATION OF MUCOADHESIVE BUCCAL FILM OF RANITIDINE HYDROCHLORIDE USING STERCULIA FOETIDA GUM AS POLYMER
Abstract
The aim of the present study was to develop buccal drug delivery system of Sterculia foetida gum and Ranitidine HCl. Buccal film of Ranitidine
HCl was developed using mucoadhesive polymer S. foetida gums like. The prepared films were evaluated in terms of their physical characteristics
and in vitro release. The formulation was optimized for the different concentration of S. foetida gum. The results of in vitro release studies showed
that optimized formulation (A4) could sustain drug release (98.79%) for 12 hrs. The release profiles were subjected to various kinetic equations
like Higuchi diffusion equation and Peppas exponential equation. The regression coefficient values of this kinetic equation are very nearer to one
suggesting that plots are fairly linear and slope values of the Peppas equation is (>1) suggest that drug was released by diffusion mechanism
following non-Fickian transport. Mucoadhesive buccal films of Ranitidine HCL sustained release, and non-Fickian transport of the drug from film
was confirmed.
Keywords: Ranitidine HCl, Buccal drug delivery system, Sterculia foetida gum, Sustaine release.
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References
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