THE RATIONALITY OF ANTIBIOTICS THERAPY TOWARD CHILDREN WITH TYPHOID FEVER AT M.M. DUNDA HOSPITAL
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i7.25631Keywords:
Antibiotic, Dunda limboto, Rationality, Typhoid, TherapyAbstract
Objectives: Typhoid fever is an acute systemic infectious disease in the small intestine caused by Salmonella enterica serotype typhi (Salmonella typhi) having the symptoms of fever a week or more with impairment of the gastrointestinal tract with or without impaired consciousness. The purpose of this study was to determine the rationality of antibiotic therapy in pediatric patients at M.M Dunda Limboto Hospital.
Methods: This research belongs to non-experimental descriptive with retrospective data retrieval. The data used were obtained from 83 medical records of childhood typhoid patients during 6 months (June–November 2016) at the regional general hospital of M.M Dunda Limboto. These data were analyzed using the Gyssens criteria.
Results: The results showed that the most antibiotics used by physicians were ceftriaxone 39% of the use of antibiotic quality which was category IIB 9%, category IIA 13%, and category 0 (rational) 52%.
Conclusion: The rationality of antibiotic therapy in children with typhoid fever at M.M Dunda Limboto Hospital was 52% of the most antibiotics used, i.e. ceftriaxone (39%).
Â
Downloads
References
KalraNaithaniMehtaSwamyJohn S, GunnJM, MarshallStephen BSabina DRichelle C, CharlesEdward T. AkhloufiRH,StreefkerkDC,MellesJEM. SteenwinkelCAM,SchurinkRP. VerkooijenCP, Van DHVerbon1. Wain J, Hendriksen RS, Mikoleit ML, Keddy KH, Ochiai RL. Typhoid Fever. Lancet 2015;385:1136-45.
Pandit RK, Gupta D, Mukherjee T. Identifications of potential Salmonella typhi Beta-lactamase TEM inhibitors using peptidomimetics, virtual screening and molecular dynamics simulations. Int J Pharm Pharm Sci 2018;10:91-6.
Sinha A, Sazawal S, Kumar R, Sood S, Reddaiah VP, Singh B, et al.Typhoid fever in children aged less than 5 years. Lancet 1999;354:734 7.
Punjabi NH. Cost evaluation of typhoid fever in Indonesia. Med J Ind 1998;7:90-3.
Simanjuntak CH. Typhoid Fever, Epidemiology and Development Research. The Mirror of Medicine Word 83. Jakarta: Garuda Portal Press; 2009.
Musnelina L, Fuad A, Ascobat G, Pratiwi A. The pattern of antibiotics treatment for child typhoid fever at fatmawati Hospital. J Inst Sains Tech Natl 2004;59:130-5.
Muslim Z, Meinisasti R. Rationality of antibiotic usage in paediatrics in Bengkulu, Indonesia: Gyssens’ criteria and type oftherapy analysis. Indian J Pharm Sci 2016;78:840-4.
Gyssens IC, Van Den Broek PJ, Kullberg BJ, Hekster Y, Van Der Meer JW. Optimizing antimicrobial therapy: A method for antimicrobial drug use evaluation. J Antimicrob Chemother 2005;30:724-7.
BNF. For Children. London: British National Formulary Publications, Royal Pharmaceutical Society of Great Britain; 2009.
Tatli MM, Aktas G, Kosecik M, Yilmaz A. Treatment of typhoid fever in children with a flexible duration of ceftriaxone, compared with a 14-day treatment with chloramphenicol. Int J Antimicrob Agents 2003;21:350 3.
Ochiai RL, Acosta CJ, Danovaro-Holliday M, Baiqing D, Bhattacharya SK, Agtini MD, et al. A study of typhoid fever in five Asian Countries: Disease burden and implications for controls. Bull World Health Organ 2008;86:260-8.
Chau TT, Campbell JI, Galindo CM, et al. Antimicrobial drug resistance of Salmonella enterica serovartyphi in Asia and molecular mechanism of reduced susceptibility to the fluoroquinolones. Antimicrob Agents Chemother 2007;51:4315-23.
Khanam F, Sayeed MD, Feroza KC, Alaullah SDA, Doli G, Lokman H, Abdullah B, Stephen BC, Richelle CC, Alejandro CET, Ryan, Firdausi Q. Typhoid Fever in Young Children in Bangladesh: Clinical Findings, Antibiotic Suspectibility Pattern And Immune Responses. Plos Neglected Tropical Disease. 2015;4:1-11.
Sucindar M, Kumaran SS. Profile of culture enteric fever in children admitted in a tertiary care hospital. J Evol Med Dent Sci 2017;6:278 802.
World Health Organization. Background Document: The Diagnosis, Treatment and Prevention of Typhoid Fever. Geneva Switzerland: WHO; 2003.
Rajesh U, Milind Y, Nadkar A, Muruganathan A, Mangesh T, Deepak A, Banka AN, et al. Api recommendations for the management of typhoid fever. J Assoc Phys India 2015;63:267.
Kalra SP, Naithani N, Mehta SR, Swamy AI. Current trends in the management of typhoid fever. Med J Armed Forces India 2003;59:130 5.
Gunn JS, Marshall JM, Stephen B, Sabina D, Charles RC, Edward T. Salmonella Chronic carriage: Epidemiology, diagnosis and gallbladder persistence. Trends Microbiol 2014;22:648-55.
Mukesh KC, Singh R, Kusum P, Pratiksha B, Ram SC, Suvash G. Efficacy of cefixime in the treatment of typhoid fever. Int J Pharm Bio Arch 2013;4:325-7.
Akhloufi RH, Streefkerk DC, Melles JE, Steenwinkel CA, Schurink RP, Verkooijen CP, et al. Point prevalence of appropriate antimicrobial therapy in a dutch university hospital. Eur J Clin Microbiol Infect Dis 2015;34:1631-7.
Shamin MD, Ali MD, Ahmad S, Ansari SM. Drug utilization based ADRS detection of antibiotics prescribed for LRTi in tertiary care teaching hospital New Delhi. Int J Pharm Pharm Sci 2018;10:7-14.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.