MICROWAVE-ASSISTED SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL EVALUATION OF PHENYLACRYLAMIDE DERIVATIVES OF TRIAZOLES DERIVED FROM OXAZOLONES

Venkat Swamy Puli; Vukoti Kiran Kumar; Venkata Reddy Regalla; Anindita Chatterjee

doi:10.22159/ajpcr.2018.v11i7.25689

Authors

Venkat Swamy Puli Department of Chemistry, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Vukoti Kiran Kumar Department of Chemistry, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Venkata Reddy Regalla Department of Chemistry, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Anindita Chatterjee Department of Chemistry, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i7.25689

Keywords:

Phenyl acrylamides, Triazoles, Oxazolones, Antimicrobial activity, Antioxidant activity

Abstract

Objective: The aim of the present study is to synthesize novel phenylacrylamide derivatives as potent bioactive agents.

Methods: Novel N-(3-(4H-1,2,4-triazol-4-ylamino)-3-oxo-1-arylidene prop-2-yl) benzimidic acids (7a-c) have been synthesized by the reaction of 4-(arylidene)-2-phenyloxazol-5(4H)-ones (5a-c) with 4-amino-1, 2, 4-triazole (6) in the presence of anhydrous sodium acetate in glacial acetic acid. Titled compounds (7a-c) were obtained in good yields using microwave technology which resulted in dramatic reductions in reaction times leading to the formation of phenylacrylamide derivatives (7a-c) at a faster rate.

Results: The structures of the newly synthesized compounds were characterized by Fourier-transform infrared, 1H NMR, 13C NMR, and mass spectral studies. This method can be an efficient method for the synthesis of phenylacrylamide derivatives (7a-c).

Conclusion: All the final compounds were screened for their antimicrobial and antioxidant activities and found to be biologically active. Among all the compounds, 7b was found to be potent antimicrobial and antioxidant.

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