THERAPEUTIC IMPACT OF BERRIES (MORUS ALBA AND MORUS RUBRA) FRUIT EXTRACT IN THE REGRESSION OF HIGH-FAT DIET-INDUCED CARDIAC DYSFUNCTION IN RATS

Authors

  • Farouk K El-baz Department of Plant Biochemistry, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, Giza, P.O.12622, Egypt. http://orcid.org/0000-0002-4750-3559
  • Hanan F Aly Department of Therapeutic Chemistry, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, Giza, P.O.12622, Egypt.
  • Howaida I Abd-alla Department of Chemistry of Natural Compounds, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, Giza, P.O.12622, Egypt.
  • Dalia F Biomy Department of Therapeutic Chemistry, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, Giza, P.O.12622, Egypt.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i7.25859

Keywords:

Mulberry fruit, Cardiac dysfunction, Cardiac fibrosis, Obesity

Abstract

Objective: The aim of the present study is to investigate the effect of Morus alba (MA) and Morus rubra L. (MR) fruit extract on obesity-induced cardiac dysfunction and fibrosis in cardiac tissue.

Methods: Seventy male Wistar albino rats were randomly divided into five groups of ten rats each. MA and MR have been administered for 6 weeks in obese rats induced by high-fat diet (HFD). Adiponectin, glucagon, troponin, plasminogen activator inhibitor, cell adhesion molecules-1 (intracellular and vascular respectively), C-reactive protein, collagen type II and collagen alpha-1 (III) chain, and lipoxygenase activity were also estimated in serum of obese rats. Histopathological investigation of cardiac tissue was carried out.

Results: MA and MR treatments significantly normalized cardiac dysfunction biomarkers as well as cardiac fibrosis as examined by histopathological examination with higher percentage of improvement for MR extract.

Conclusion: Hence, it could be concluded that MA and MR extracts have useful effects on obesity-associated cardiac diseases through lipid metabolism regulation, cardiac functions and reversed cardiac fibrosis.

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Author Biography

Farouk K El-baz, Department of Plant Biochemistry, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, Giza, P.O.12622, Egypt.

Plant Biochemistry

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Published

07-07-2018

How to Cite

El-baz, F. K., H. F. Aly, H. I. Abd-alla, and D. F. Biomy. “THERAPEUTIC IMPACT OF BERRIES (MORUS ALBA AND MORUS RUBRA) FRUIT EXTRACT IN THE REGRESSION OF HIGH-FAT DIET-INDUCED CARDIAC DYSFUNCTION IN RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 7, July 2018, pp. 314-20, doi:10.22159/ajpcr.2018.v11i7.25859.

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