ENVIRONMENTAL EXPOSURES TO LOW LEVEL OF CADMIUM AND LEAD AND HEARING IMPAIRMENT IN IRAQI PATIENTS

Wrood S Al-khfajy; Ghadeer Kadhum Baiee; Inam Sameh Arif

doi:10.22159/ajpcr.2018.v11i7.26235

Authors

Wrood S Al-khfajy Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq. http://orcid.org/0000-0003-4451-8939
Ghadeer Kadhum Baiee Babel Health Directorate, Forensic division, Drugs and Poison Unit, Iraq.
Inam Sameh Arif Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i7.26235

Keywords:

Cadmium, Hearing loss, Lead, Environmental toxicology, Pure-tone audiometry

Abstract

Objectives: We examined the relations between blood cadmium and lead exposure and hearing impairments in the Iraqi people.

Methods: We analyzed data from 51 individual 13â€“75 ages who had been randomly dispensed to the audiometry examination center at Al-Hilla Teaching Hospital (Babel) for each Iraqi civilian who said, I suffering from the hearing problem.â€ Pure-tone average (PTA) of auditory thresholds at frequencies of 0.5, 1, 2, and 4 kHz was calculated, and hearing impairment was described as a PTA >25 dB in either ear.

Results: All patients who suffer from hearing impairment have serum lead level (23.14Â±1.76 Î¼g/dL), which is a significantly elevated in comparison to control group (21.20Â±2.08 Î¼g/dL). In addition to lead, the blood level of cadmium in people with hearing impairment was showed a significant elevation (0.28Â±0.05 Î¼g/dL) in comparison to normal people (0.22Â±0.03 Î¼g/dL). In general, this elevation remains within normal reference for the blood level of cadmium (0.5 Î¼g/dL).

Conclusions: The present study revealed that the environmental and occupational cadmium and lead coexposures lead to a significant elevation in the blood level of these metals and could have an essential part in the progression of hearing loss.

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