ANTICANCER ACTIVITY OF ZINC OXIDE AND ZINC OXIDE/CADMIUM SULFIDE NANOCOMPOSITES
DOI:
https://doi.org/10.22159/ajpcr.2019.v12i2.26265Keywords:
Medical applications of nanocomposites, Antitumor activity, Antioxidant activityAbstract
Objective: The objective of this study is to investigate the anticancer activity of zinc oxide (ZnO) and ZnO/cadmium sulfide (CdS) nanoparticles (NPs). These NPs were active index against five human tumor cell lines, namely hepatocellular carcinoma, mammary gland (MCF-7), epidermoid carcinoma (HEP2), colorectal carcinoma (HCT-116), and rhabdomyosarcoma (RD).
Methods: ZnO and ZnO/CdS NPs were synthesized using zinc acetate dihydrate and oxalic acid. The samples are characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and atomic force microscopy (AFM).
Results: The results were indicated that these NPs can be used to made drug delivery system depending on ZnO and ZnO/CdS nanocomposites for its potential role in enhancing the anticancer efficacy of doxorubicin as well as work on reducing side effects.
Conclusions: ZnO and ZnO/CdS nanocomposites can be used anticancer for five human tumor cells.
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