STUDIES ON HEPATOPROTECTIVE AND ANTI-INFLAMMATORY ACTIVITY OF COIX LACRYMAâ€“JOBI (LINN)
Keywords:Anti-inflammation, Coix lacryma-jobi, Hepatotoxicity, Rheumatoid arthritis, and Edema
Objective: In the present study, evaluation of hepatoprotective activity of Coix lacryma-jobi by CCl4-induced hepatotoxicity test, and evaluation of anti-inflammatory activity of by egg albumin-induced paw edema, and complete Freund's adjuvant-induced arthritis model were done.
Methods: Plant extract was prepared by mixing ethanol with powdered plant seeds and experiment was done as per the procedures of above-mentioned three models.
Results: C. lacryma-jobi test extracts out of two doses, 400 mg/kg exhibited a significant reduction in serum cholesterol level as 33 mg/dl when compared to control groups. C. lacryma-jobi seed extract has restored various serological alterations following CCl4-induced hepatotoxicity and was capable of reversing the toxic effects of CCl4 on liver cells. Considerable reduction in the paw volume of exudates observed with C. lacryma-jobi extract, indicating significant anti-inflammatory activity.
Conclusion: Therefore, this study shows that C. lacryma-jobs seed extract have anti-inflammatory activity in the models studied.
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