FORMULATION AND EVALUATION OF RED PALM OLEIN NANOEMULSION

Febia Sari; Kasmirul Ramlan Sinaga; Donald Siahaan

doi:10.22159/ajpcr.2018.v11i9.26532

Authors

Febia Sari Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Kasmirul Ramlan Sinaga Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Donald Siahaan Indonesian Oil Palm Research Institute, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i9.26532

Keywords:

Red palm olein, Nanoemulsion, Spontaneous emulsification, Surfactant, Cosurfactant

Abstract

Objective: The objective of this study is to formulate and evaluate the red palm olein (RPO) nanoemulsion using spontaneous emulsification method.

Methods: Nanoemulsion formulated by spontaneous emulsification method using the comparison of surfactant (tween 80) and cosurfactant (sorbitol) concentration with the variation of RPO concentration. Evaluation of the stability of the nanoemulsion preparation includes centrifugation test, viscosity, pH, organoleptic observation (odor, color, clarity, and phase separation), and particle size measurement during 12 weeks storage at room temperature.

Result: The results showed that all nanoemulsion preparations were transparent yellow, characteristic odor, type weights 1.0166â€“1.0641 g/ml, and stable for 12 weeks storage at room temperature. The smallest particle size was produced by the nanoemulsion preparation in a formula of the concentration of 5%, which was 67, 64 nm.

Conclusion: RPO can be formulated as a nanoemulsion by spontaneous emulsification method. RPO with a 5% concentration is very stable for 12 weeks storage.

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Author Biographies

Febia Sari, Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Department of Pharmaceutical Technology

Kasmirul Ramlan Sinaga, Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Department of Pharmaceutical Technology

Donald Siahaan, Indonesian Oil Palm Research Institute, Medan, Indonesia.

Department of Product Processing and Quality

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