ANTIHYPERURICEMIC ACTIVITY OF ETHANOL EXTRACT OF SYZYGIUM CUMINI LEAVES ON POTASSIUM OXONATED-INDUCED RATS

Mona Asiah; Rosidah Rosidah; Yuandani Yuandani

doi:10.22159/ajpcr.2018.v11s1.26587

Authors

Mona Asiah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Rosidah Rosidah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Yuandani Yuandani Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26587

Keywords:

Ethanol extract of Syzygium cumini leaves, Serum uric acid, Potassium oxonate

Abstract

Objective: This study was conducted to investigate the effect of extract of Syzygium cumini on serum uric acid levels of rats induced by potassium oxonate.

Methods: A total of 30 male Wistar rats were randomly divided into six groups, consist of one normal group (without treatment) and five groups that were induced by potassium oxonate 250 mg/kg bw intraperitoneally for 7 days. The ethanol extract of S. cumini leaves dose (100, 200, and 400 mg/kg bw) was administered orally 1 h after the potassium oxonate exposure during 7 days. On day 8, blood samples were collected for serum uric acid determination.

Result: Ethanol extract of S. cumini leaves at doses of 100 mg/kg bw, 200 mg/kg bw, and 400 mg/kg bw significantly reduced serum uric acid as compared to negative control group of carboxymethylcellulose 0.5%.

Conclusion: Ethanol extract of S. cumini leaves can be used as antihyperuricemic agent.

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