IS URINARY CREATININE ASSOCIATED WITH WASTING IN NEONATES

Sri Widia Ningsih; Nita Andriani Lubis; Aslis Wirda Hayati; Alkausyari Azis

doi:10.22159/ajpcr.2018.v11s1.26603

Authors

Sri Widia Ningsih Department of Pharmacy, Medan Health Polytechnic, Jl. Airlangga No. 20 Medan Indonesia 20112.
Nita Andriani Lubis Department of Health Analyst, Medan Health Polytechnic, Jl. William Iskandar Pasar V Barat No. 6 Medan Estate, Indonesia 20137
Aslis Wirda Hayati Department of Nutrition, Riau Health Polytechnic, Pekanbaru, Indonesia.
Alkausyari Azis Department of Nutrition, Riau Health Polytechnic, Pekanbaru, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26603

Keywords:

Biomarker, Creatinine urine, Neonates, Wasting

Abstract

Objective: To analyze the correlation between creatinine urine and wasting in neonates.

Methods: The study was cross sectional by involving 35 healthy neonates aged 1â€“3 days that were born at Pekanbaru Andini Hospital, Indonesia, on August to September 2014. Body length gauges, digital weighing scale, family socioeconomic questionnaires, pediatrics urine collection bag, and creatinine urine were used to collect the data. We used two indicators (creatinine urine and weight/height [WH]) as a parameter in this study. Pearson correlation (significance p<0.05 and p<0.01) was applied for statistical analysis.

Results: There was no wasting neonates, WH z-score (WHZ) >-2 SD. The concentrations of absolute creatinine urine excretion were about 11.1â€“167.2 mmol/day, and creatinine urine excretion related to body weight was about 4.08â€“50.06 mmol/Kg/day. Bivariate analysis obtained that there were negative significant correlation between the absolute creatinine urine (r=âˆ’0.357, p=0.035) and creatinine urine â€“ body weight (r=âˆ’0.482, p=0.003) with WH. Creatinine urine measurement is a sensitive biomarker of renal and total muscle mass that can be used as a child's growth biomarker.

Conclusion: The creatinine urine was associated with wasting in neonates therefore can be used as a growth biomarker.

Downloads

Download data is not yet available.

References

Indonesian Health Ministry. National Basic Health Research. Jakarta. Indonesian Health Ministry; 2013.

Fernandez ID, Hilmes JH, de Onis M. Prevalence of nutritional wasting in populations: Building explanatory model using secondary data. Bull World Health Organ 2002;80:282-91.

World Health Assembly Target 2025: Wasting Policy Brief. WHO; 2014. Available from: http://www.who.int/nutrition/topics/globaltargets_ wasting_policybrief.pdf.[Last accessed on 2017 Jun 04].

Mgongo M, Chotta NA, Hashim TH, Uriyo JG, Damian JD, Pedersen BS, et al. Underweight, stunting and wasting among children in Kilimanjaro Region, Tanzania; A population-based cross-sectional. Int J Environ Res Public Health 2017;14:439.

Kerac M, Blencowe H, Grijalva-Eternod C, McGrath M, Shoham J, Cole TJ, et al. Prevalence of wasting among under 6-month-old infants in developing countries and implications of new case definitions using WHO growth standards: A secondary data analysis. Arch Disease Child 2011;96:1008-13.

Manila RM, Bouchard C, Bar-Or O. Growth, Maturation and Physical Activity. 2nd ed. New Zealand: Human Kinetics Publisher; 2004.

Andreev E, Koopman M, Arisz L. A rise in plasma creatinine that is not a sign of renal failure: Which drugs can be responsible? J Intern Med 1999;246:247-52.

Sulemanji M, Vakili K. Neonatal renal physiology. Semin Pediatr Surg 2013; 22: 195â€“198.

Hayati AW, Aziz A, Ningsih SW. The Pyridinium Crosslinks of Urine is Associated with Body Length in Neonates. Indonesia, Jakarta: Seminar in Responding to the Nutrition Transition in Asia Pacific Region; 2016.

Naâ€™im A, Syaputra H. Citizenship, Ethnicity, Religion and Language of the Indonesian Population, the Results of the 2010 Population Census. Jakarta-Indonesia: International Crisis Group (ICG); 2011. p. 36.

Mahyar A, Ayazi P, Fallahi M, Javadi TH, Farkhondehmehr B, Javadi A, et al. Prevalence of underweight, stunting and wasting among children in Qazvin, Iran. Iran J Pediatr Soc 2010;2:37-43.

Ibrahim M, Forsyth JS. Lifestyle and maternal health interaction between mother and fetus. In: Jane BM, John WT, editors. Nutrition in Early Life. Chichester: John Wiley & Sons Ltd.; 2003. p. 1-38.

Creatinine Random Urine; 2017. Available from: http://www. questdiagnostics.com/testcenter/TestDetail.action?ntc=8459. [Last accessed on 2017 Aug 25].

Allegaert K, Vermeersch P, Smits A, Mekahli D, Levtchenko, Pauwels S. Paired measurement of urinary creatinine in neonates based on a Jaffe and an enzymatic IDMS-traceable assay. BioMed Central Nephrol 2014;15:62.

Sharkawy AM, Sahota O, Maughan RJ, Lobo DN. The pathophysiology of fluid and electrolyte balance in the older adult surgical patient. Clin Nutr 2014;33:6-13.

Poggio ED, Nef PC, Wang X, Greene T, Van Lente F, Dennis VW, et al. Performance of the cockcroft-gault and modification of diet in renal disease equations in estimating GFR in ill hospitalized patients. Am J Kidney Dis 2005;46:242-52.

Remer T, Neubert A, Masser-Gluth C. Anthropometry-based reference values for 24-h urinary creatinine excretion during growth and their use in endocrine and nutritional research. Am J Clin Nutr 2002;75:561-9.

Howard TE. Clinical Chemistry. New York: John Wiley and Sons; 1989. p. 4, 58-62.