DESIGN, SYNTHESIS, AND DOCKING OF SULFADIAZINE SCHIFF BASE SCAFFOLD FOR THEIR POTENTIAL CLAIM AS INHA ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE INHIBITORS

Prabha Thangavelu; Sivakumar Thangavel

doi:10.22159/ajpcr.2018.v11i10.27179

Authors

Prabha Thangavelu Department of Pharmaceutical Chemistry, Nandha College of Pharmacy, Erode â€“ 638 052, Tamil Nadu, India.
Sivakumar Thangavel Department of Pharmaceutical Chemistry, Nandha College of Pharmacy, Erode â€“ 638 052, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i10.27179

Keywords:

Antimycobacterial activity, Sulfadiazine Schiff base, Molecular docking study

Abstract

Objective: An effort was made to design and synthesize the series of sulfadiazine building blocks as a targeted candidate for antimycobacterial activity.

Method: The synthesized compounds were subjected to preliminary in silico screening study for testing their antimycobacterial action by doing their molecular docking study on bioinformatics software, molecular operating environment 2009.10.

Result: The results obtained from this tool showed that there is a best docking affinity score of these target compounds against the enzyme InhA Enoyl-(acyl-carrier-protein) reductase from Mycobacterium tuberculosis (MTB) pathogen, which is one of the key enzymes involved in the type II fatty acid biosynthesis pathway of MTB.

Conclusion: Thus, the synthesized sulfadiazine Schiff base derivatives might serve as the best drug candidate for the existence of menacing pathogen MTB.

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