REVIEW ON TRANSDERMAL MICRONEEDLE-BASED DRUG DELIVERY
DOI:
https://doi.org/10.22159/ajpcr.2019.v12i1.27434Keywords:
Microneedles, Transdermal patches, Insulin, Drug deliveryAbstract
Drug delivery research extensively studies methods to transport proteins, deoxyribonucleic acid (DNA), genes, antibodies, and vaccines efficiently and safely to human bodies in recent years. This review comprehensively covers the developments in microneedle-based drug delivery, their configurations, design, fabrication, and operation. The factors surrounding the mechanical strength of microneedle-based transdermal patches (MNTP's) have also been reviewed. MNTP's can eliminate limitations of conventional drug delivery systems. Microneedle-based transdermal delivery approach will offer a self-management, patient-friendly, and efficient administration route for drug delivery.
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Lee JW, Park JH, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials 2008;29:2113-24.
Donnelly RF, Singh TR, Garland MJ, Migalska K, Majithiya R, McCrudden CM, et al. Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. Adv Funct Mater 2012;22:4879 90.
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Crichton ML, Ansaldo A, Chen X, Prow TW, Fernando GJ, Kendall MA, et al. The effect of strain rate on the precision of penetration of short densely-packed microprojection array patches coated with vaccine. Biomaterials 2010;31:4562-72.
Yan G, Warner KS, Zhang J, Sharma S, Gale BK. Evaluation needle length and density of microneedle arrays in the pretreatment of skin for transdermal drug delivery. Int J Pharm 2010;391:7-12.
Gill HS, Denson DD, Burris BA, Prausnitz MR. Effect of microneedle design on pain in human volunteers. Clin J Pain 2008;24:585-94.
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