IMMUNOHISTOCHEMICAL EXPRESSION OF C-KIT IN ORAL SQUAMOUS CELL CARCINOMA PATIENTS IN SOUTH INDIAN POPULATIONS

Jayalalitha Sathiyamoorthy; Vidyarani Shyamsundar; Subbiah Shanmugam; Jagadeesan G Mani; Rajeswary Hari

doi:10.22159/ajpcr.2018.v11i10.27443

Authors

Jayalalitha Sathiyamoorthy Department of Biotechnology, Dr. M.G.R. Educational and Research Institute, Maduravoyal, Chennai â€“ 600 099, Tamil Nadu, India.
Vidyarani Shyamsundar Department of Oral Pathology and Microbiology, Centre of Oral Cancer Prevention and Research, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education, Pallikaranai, Chennai - 99, Tamil Nadu, India.
Subbiah Shanmugam Department of Surgical Oncology, Government Royapettah Hospital and Kilpauk Medical College, Chennai, Tamil Nadu, India.
Jagadeesan G Mani Department of Surgical Oncology, Government Royapettah Hospital and Kilpauk Medical College, Chennai, Tamil Nadu, India.
Rajeswary Hari Department of Biotechnology, Dr. M.G.R. Educational and Research Institute, Maduravoyal, Chennai â€“ 600 099, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i10.27443

Keywords:

Oral squamous cell carcinoma, Oral epithelial dysplasia, Immunohistochemistry, C-KIT

Abstract

Objective: The study was designed to evaluate the C-Kit expression and also to assess the relationship with various clinicopathological characteristics in oral squamous cell carcinoma (OSCC) patients.

Methods: A total number of 102 formalin-fixed paraffin-embedded retrospective tissue samples were collected, in which (n =84) were histologically confirmed for OSCC, oral epithelial dysplasia (OED) (n=9), and control group (n=10) and studied immunohistochemically. The baseline characters and the correlation between the protein expression and clinicopathological parameters were analyzed. The survival analysis was performed using Kaplan-Meier Survival Method.

Results: OSCC exhibited C-Kit protein expression positivity of 6% and OED with 11.11% with no expression of this protein in control patients. Overall survival analysis showed that patients with negative expression had a better survival than patients with positive expression. However, we found that expression pattern of C-kit did not correlate with various clinicopathological characteristics.

Conclusion: Vast amount of study has to be still performed to under the mechanism of OSCC in C-KIT Expression to enhance the prognosis of OSCC patients in the near future.

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