SARGASSUM POLYCYSTUM METHANOL EXTRACT AFFECTS THE NUCLEAR FACTOR-k BETA AND INTERLEUKIN-6 EXPRESSION IN STREPTOZOTOCIN-INDUCED DIABETES RATS

Muhamad Firdaus; Anies Chamidah

doi:10.22159/ajpcr.2018.v11i11.27658

Authors

Muhamad Firdaus Department of Fish Product Technology, Faculty of Fisheries and Marine Sciences, Brawijaya University, Malang-65145, Indonesia.
Anies Chamidah Department of Fish Product Technology, Faculty of Fisheries and Marine Sciences, Brawijaya University, Malang-65145, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i11.27658

Keywords:

Diabetes mellitus, Free radical, Inflammation, Sargassum polycystum

Abstract

Objective: The objective of this study is to investigate the attenuation of the nuclear factor-Îº beta (NF-ÎºB) and interleukin (IL)-6 expression in streptozotocin-induced diabetic rats by Sargassum polycystum methanol extract.

Methods: Diabetic rats were intraperitoneally induced by streptozotocin (40 mg/kg b.w.). S. polycystum methanol extract was administered to diabetic rats for 45 days. The effect of S. polycystum methanol extract on blood glucose, hemoglobin A1c (HbA1c), NF-ÎºB, and IL-6 expression was investigated on streptozotocin-induced diabetic rats. The gliclazide (30 mg/kg b.w., p.o.) was used as a reference antidiabetic drug.

Results: The administration of S. polycystum methanol extract on streptozotocin-induced diabetic rats decreased the blood glucose level, HbA1c, NF-ÎºB, and IL-6.

Conclusion: S. polycystum methanol extract indicates a promising anti-inflammation agent in diabetes.

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