A REVIEW ON MEDICINAL PLANTS OF RAJASTHAN HAVING ANTIDIABETIC ACTIVITY
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i12.28176Keywords:
Antidiabetic, Antihyperglycemic, HypolipidemicAbstract
Diabetes is one of the most common chronic diseases in nearly all countries, and continuously increasing in numbers and significance, as changing lifestyles lead to reduced physical activity. Diabetes is the leading cause of blindness, renal failure, and lower limb amputation. Diabetes is also now one of the leading causes of death, largely because of a markedly increased risk of coronary heart disease and stroke. Due to the existing synthetic drugs have many limitations, the medicine from plants is drawing ever-increasing attention worldwide, due to their low toxicity and few side effects. The present review is providing data of some important medicinal plants species possessing antihyperglycemic and antidiabetic activity. It would provide a handbook for the research related to diabetes. Further, efforts should be made to implement these plants based drugs in clinical trials.
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Okon JE, Ofeni AA. Antidiabetic effect of Dioscorea bulfifera on alloxan-induced diabetic rats. CIB Tech J Pharm Sci 2013;1:14-9.
Sachan NK, Kumar Y, Pushkar S, Thakur RN, Gangwar SS, Kalaichelvan VK, et al. Antidiabetic potential of alchohol and aqueous extracts of Ficus racemosa Linn. Bark in normal and alloxan-induced diabetic rats. Int J Pharm Sci Drug Res 2009;1:24-7.
Sicree R, Shaw J, Zimmet P. The global burden. diabetes and impaired glucose tolerance. prevalence and projections. In: Gan D, editor. Diabetes Atlas. 3rd ed. Brussels: International Diabetes Federation; 2006. p. 16-103.
Matheka DM, Alkizim FO. Complementary and alternative medicine for Type 2 diabetes mellitus: Role of medicinal herbs. J Diabetes Endocrinol 2012;3:44-56.
Khan A, Anderson RA. Insulin potentiating factor (IPF) present in foods, species and natural products. Pak J Nutr 2003;2:254-7.
Malviya N, Jain S, Malviya S. Antidiabetic potential of medicinal plants. Acta Pol Pharm 2010;67:113-8.
Jain A, Katewa SS, Galav P, Nag A. Some therapeutic uses of biodiversity among the tribals of Rajasthan. Indian J Tradit Knowl 2008;7:256-62.
Pareek P, Choudhry M. Management of Type 2 diabetics by Indian gum Arabic (Acacia nilotica) pods powder. Int J Food Nutr Sci 2013;2:77 83.
Nayak P, Kar DM, Maharana L. Antidiabetic activity of aerial parts of Argemone mexicana L. In alloxan induced hyperglycaemic rats. Pharmacol Online2011;1:889-903.
Rathee S, Rathee P, Rathee D, Rathee D, Kumar V. Phytochemical and pharmacological potential of kair (Capparis decidua). Int J Phytomed 2010;2:7-10.
Singh D, Singh RK. Kair (Capparis decidua): A potential ethnobotanical weather predictor and livelihood security shrub of the arid zone of Rajasthan and Gujarat. Indian J Tradit Knowl 2011;10:146-55.
Upadhyay RK. Kareelplant: A natural source of medicines and nutrients. Int J Green Pharm (IJGP) 2011;5:255-65.
Verma PD, Dangar RD, Shah KN, Gandhi DM, SuhagiaBN. Pharmacognostical potential of Capparis deciduas Edgew. J Appl Pharm Sci 2011;1:6-11.
Jean HR, Jean MN, Gaelle LC, Philippe T, Monique ZH, Louisette LM, et al. Isolation of indole alkaloids from Catharanthus roseus by centrifugal partition chromatography in the pH-zone refining mode. J Chromatogr A 1999;849:421-31.
Sumana G, Suryawanshi SA. Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rat. Indian J Exp Biol 2001;39:748 59.
Antia BS, Okokon JE. Effect of leaf juice of Catharanthus roseus Linn. On cholesterol, triglyceride and lipoproteins levels in normal rats. Indian J Pharm 2005;37:401-2.
Jaleel CA, Gopi R, Manivannan P, Sankar B, Kishorekumar A, Panneerselvam R, et al. Antioxidant potentials and ajmalicine accumulation in Catharanthus roseus after treatment with giberellic acid. Colloids Surf B Biointerfaces 2007;60:195-200.
Gilles B, Marie GD, Bruno D, Anne MM. A new flavonol glycoside from Catharanthus roseus. Phytochemistry 1999;50:167-9.
Akirai S. Brassinosteroid biosynthesis. Plant Physiol Biochem 1999;37:351-61.
Ramadan MF, Zayed R, El-Shamy H. Screening of bioactive lipids and radical scavenging potential of some Solanaceae plants. Food Chem 2007;103:885-90.
Zhang M, Chen M, Zhang HQ, Sun S, Xia B, Wu FH, et al. In vivo hypoglycemic effects of phenolics from the root bark of Morus alba. Fitoterapia 2009;80:475-7.
Yang X, Yang L, Zheng H. Hypolipidemic and antioxidant effects of mulberry (Morus alba L.) fruit in hyperlipidaemia rats. Food Chem Toxicol 2010;48:2374-9.
Wang CP, Wang Y, Wang X, Zhang X, Ye JF, Hu LS, et al. Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Planta Med 2011;77:786-94.
Kim JK, Kim M, Cho SG, Kim MK, Kim SW, Lim YH, et al. Biotransformation of mulberroside a from Morus alba results in enhancement of tyrosinase inhibition. J Ind Microbiol Biotechnol 2010;37:631-7.
Naowaboot J, Pannangpetch P, Kukongviriyapan V, Kongyingyoes B, Kukongviriyapan U. Antihyperglycemic, antioxidant and antiglycation activities of mulberry leaf extract in streptozotocin-induced chronic diabetic rats. Plant Foods Hum Nutr 2009;64:116-21.
Flexible Dose Open trial of Vijayasar in Cases of Newly-Diagnosed Non-insulin-Dependent Diabetes Mellitus. Indian council of medical research (ICMR), collaborating centres, New Delhi. Indian J Med Res 1998;108:24-9.
Hui H, Tang G, Go VL. Hypoglycemic herbs and their action mechanisms. Chin Med 2009;4:11.
Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 2003;84:105-8.
van de Venter M, Roux S, Bungu LC, Louw J, Crouch NR, Grace OM, et al. Antidiabetic screening and scoring of 11 plants traditionally used in South Africa. J Ethnopharmacol 2008;119:81-6.
Pathak AK, Saraf S, Dixit VK. Hepatoprotective activity of Tridax procumbens-Part I. Fitoterapia 1991;62:307-13.
Ravikumar V, Shivashangari KS, Devaki T. Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galactosamine sensitised rats. Mol Cell Biochem 2005;269:131-6.
Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: Council of Scientific and Industrial Research; 1945. p. 259.
Moerman D. Native American Ethnobotany. Oregon. Portland: Timber Press; 1998. p. 453-9.
AgarwalA. Critical issues in quality control of herbal products. Pharm Times 2005;37:9-11.
Khanra R, Dewanjee S, K Dua T, Sahu R, Gangopadhyay M, De Feo V, et al. Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response. J Transl Med 2015;13:6.
Srivastava SP, Mishra A, Bhatia V, Tadigoppula N, Srivastava AK. Acacia catechu hard wood: Potential anti-diabetic cum anti-dyslipidemic. Med Chem Res 2011;20:1732-9.
Kumar S, Chodhary M, Yadav P, Nitesh N, Budhawar V. Anti-diabetic activity of hydroalcoholic extract of Acacia melanoxylon Linn. Seeds in streptozotocin induced diabetic rats. J Diabetes Res Ther 2016;2:3.
Saha D, Ghosh SK, Das T, Mishra SB. Hypoglycemic and antihyperlipidemic effects of Adiantum caudatum in alloxan induced diabetes in rats. Asian J Pharm Clin Res 2016;9:361-3.
Kumar D, Kumar S, Kohli S, Arya R, Gupta J. Antidiabetic activity of methanolic bark extract of Albizia odoratissima Benth. In alloxan induced diabetic albino mice. Asian Pac J Trop Med 2011;4:900-3.
Rajan TS, Aanandhi VM. Antidiabetic activity of ethanolic extract of Alternanthera ficodia Linn in streptozotocin induced diabetic rats. Int J Pharm Bio Sci 2016;7:177-80.
Akter R, Mahabub-Uz-Zaman M, Rahman MS, Khatun MA, Abdullah AM, Ahmed NU, et al. Comparative studies on antidiabetic effect with phytochemical screening of Azadirachta indicia and Andrographis paniculata. IOSR J Pharm Biol Sci 2013;5:122-8.
Biworo A, Tanjung E, Iskandar R, Khairina S, Suhartono E. Antidiabetic and antioxidant activity of jackfruit (Artocarpus heterophyllus) extract. J Med Bioeng 2015;4:318-23.
Hannan JM, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel-Wahab YH, et al. Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic b-cells. J Endocrinol 2007;192:159-68.
Nazreen S, Kaur G, Alam MM, Haider S, Hamid H, Alam MS, et al. Hypoglycemic activity of Bambusa arudiacea leaf ethaolic extract in streptozotocin induced diabetic rats. Pharmacol Online 2011;1:964-72.
Kanagavalli U, Bhuvaneshwari B, Sadiq AM. Antidiabetic activity of Boerhaavia diffusa against alloxan induced diabetic rats. Int J Pharm Bio Sci 2015;6:1215-9.
Rahmatullah M, Shefa TF, Hasan L, Hossain MT, Ahmed S, Mamun AA, et al. A study on antinociceptive and anti-hyperglycemic activity of methanol extract of Brassica juncea Linn. Czern. Leaves in mice. Adv Nat Appl Sci 2010;4:221-5.
Assad T, Khan RA, Feroz Z. Evaluation of hypoglycemic and hypolipidemic activity of methanol extract of Brassica oleracea. Chin J Nat Med 2014;12:648-53.
Neto MC, de Vasconcelos CF, Thijan VN, Caldas GF, Araújo AV, Costa- Silva JH, et al. Evaluation of antihyperglycaemic activity of Calotropis procera leaves extract on streptozotocin-induced diabetes in wistar rats. Rev Bras Farmacogn 2013;23:913-9.
Magied MM, Salama NA, Ali MR. Hypoglycemic and hypocholesterolemia effects of intragastric administration of dried red chili pepper (Capsicum annum) in alloxan-induced diabetic male albino rats fed with high-fat-diet. J Food Nutr Res 2014;2:850-6.
Malpani SN, Manjunath KP, Sholapur H, Savadi RV, Akki KS, Darade SS, et al. Antidiabetic activity of Cassia fistula Linn. Bark in alloxan induced diabetic rats. Int J Pharm Sci 2010;2:382-5.
Cheng DM, Kuhn P, Poulev A, Rojo LE, Lila MA, Raskin I, et al. In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix. Food Chem 2012;135:2994-3002.
Piero NM, Eliud NM, Susan KN, George OO, David NJ, Sakyi AD, et al. In vivo antidiabetic activity and safety in rats of Cissampelos pareira traditionally used in the management of diabetes mellitus in Embu county, Kenya. J Drug Metabol Toxicol 2015;6:180.
Akhila S, Bindu AR, Bindu K, Aleykutty NA. Phytochemical and pharmacological evaluation of Citrus limon peel. World J Pharm Pharm Sci 2015;4:1128-30.
Olatunde A, Joel EB, Tijjani H, Obidola SM, Luka CD. Anti-diabetic activity of aqueous extract of Curcuma longa (Linn) rhizome in normal and alloxan-induced diabetic rats. Researcher 2014;6:58-65.
Pund KV, Vyawahare NS, Gadakh RT, Murkute VK. Antidiabetic evaluation of Dalbergia Sissoo against alloxan induced diabetes mellitus in wistar albino rats. J Nat Prod Plant Resour 2012;2:81-8.
Song MK, Um JY, Jang HJ, Lee BC. Beneficial effect of dietary Ephedra sinica on obesity and glucose intolerance in high-fat diet-fed mice. Exp Ther Med 2012;3:707-12.
Basak SS, Candan F. Chemical composition and in vitro antioxidant and antidiabetic activities of Eucalyptus Camaldulensis Dehnh. Essential oil. J Iran Chem Soc 2010;7:216-26.
Devi S, Kumar M. In-vivo antidiabetic activity of methanolic extract of Euphorbia hirta L. Int J Diabetes Endocrinol 2017;2:36-9.
Nasution R, Marianne M, Kausar A. Antidiabetic activity of ARA (Ficus racemosa) from ACEH. Int J Chem Tech Res 2010;10:9-10.
Mhaidat NM, Abu-zaiton AS, Alzoubi KH, Alzoubi W, Alazab RS. Antihyperglycemic properties of Foeniculum vulgare Extract in streptozotocin- induced diabetes in rats. Int J Pharmacol 2015;11:72 5.
El Shafey AA, El-Ezabi MM, Seliem MM, Ouda HH, Ibrahim DS. Effect of Gymnema sylvestre R.Br. Leaves extract on certain physiological parameters of diabetic rats. J King Saud Univ Sci 2013;25:135-41.
Ogunrinola OO, Fajana OO, Olaitan SN, Adu OB, Akinola MO. Anti-diabetic activity of Ipomoea batatas Leaves extract: Effects on hepatic enzymes in alloxan-induced diabetic rats. Res J Med Plant 2015;9:227 33.
Johnson M, Olufunmilayo LA, Adegboyega CC, Adetayo OM. Evaluation of antidiabetic and the effect of methanolic leaf extract of Jatropha curcas on some biochemical parameters in alloxan induced diabetic male albino rats. Eur J Med Plants 2014;4:1501-12.
Gupta R, Mathur M, Bajaj VK, Katariya P, Yadav S, Kamal R, et al. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J Diabetes 2012;4:164-71.
Al-Ani IM, Santosa RI, Yankuzo MH, Saxena AK, Alazzawi KS. The antidiabetic activity of curry leaves Murraya koenigii†on the glucose levels, kidneys, and islets of Langerhans of rats with streptozotocin induced diabetes. Makara J Health Res 2017;21:54-60
Sakuljaitrong S, Buddhakala N, Chomko S, Talubmook C. Effects of flower extract from lotus (Nelumbo nucifera) on hypoglycemic and hypolipidemic in streptozotocin-induced diabetic rats. Int J Sci Eng Res 2013;4:1441-6.
Fartyal M. Nerium oleander Linn. In vitro alpha amylase inhibitory potential of stem and root extracts. Int J Curr Pharm Res 2017;9:37 41.
Sharma V, Marwaha AP. Hypoglycemicactivity of methanolic extracts of Nyctanthes arbor-tristis Linn. Root in alloxan induced diabetic rats. Int J Pharm Pharm Sci 2011;3:210-2.
Malairaman U, Mehra V, Sharma A, Khailkhura P. Antioxidant, anti-inflammatory, and antidiabetic activity of hydroalcoholic extract of Ocimum sanctum: An in-vitro and in-silico study. Asian J Pharm Clin Res 2016;9:44-9.
Zhao LY, Lan QJ, Huang ZC, Ouyang LJ, Zeng FH. Antidiabetic effect of a newly identified component of Opuntia dillenii polysaccharides. Phytomedicine 2011;18:661-8.
Shimoda H, Aitani M, Tanaka J, Hitoe S. Purple rice extract exhibits preventive activities on experimental diabetes models and human subjects. J Rice Res 2015;3:137.
Antia BS, Okokon JE, Umoh EE, Udobang JA. Antidiabetic activity of ethanolic leaf extract of Panicum maximum. Int J Drug DevRes 2010;2:488-92.
Kasali FM, Kadima JN, Mpiana PT, Ngbolua K, Tshibangu DS. Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L. In guinea-pig. Asian Pac J Trop Biomed 2103;3:841-6.
Kumar S, Sharma S, Jitpal S. In vivo anti-hyperglycemic and antioxidant potential of Piper longum fruit. J Pharm Res 2011;4:471-4.
Inagaki K, Nishimura Y, Iwata E, Manabe S, Goto M, Ogura Y, et al. Hypolipidemic effect of the autoclaved extract prepared from pea (Pisum sativum L.) pods in vivo and in vitro. J Nutr Sci Vitaminol (Tokyo) 2016;62:322-9.
Godebo A, Makonnen E, Mekonnen N. Hypoglycemic and antihyperglycemic effect of leaves extracts of Psidium guajava in normoglycemic and streptozotocin-induced diabetic mice. Int J Pharm 2017;4:250-6.
Azmi MB, Qureshi SA. Glucose lowering potential of hydromethanolic extract of Rauwolfia serpentine benth, improves the glycemic, antiatherogenic, and cardioprotective indices in alloxan-induced diabetic mice. World J Pharm Sci 2014;2:219-23.
Widyawati T, Yusoff NA, Asmawi MZ, Ahmad M. Antihyperglycemic effect of methanol extract of Syzygium polyanthum (Wight.) leaf in streptozotocin-induced diabetic rats. Nutrients 2015;7:7764-80.
Al-Ahdab MA. Anti-hyperglycemic effect of Tamarindus indica extract in streptozotocin-induced diabetes in male rats. World Appl Sci J 2015;33:1940-8.
Krishnasamy R. Antioxidant and antidiabetic activity of Tectona grandis Linn. In alloxan induced albino rats. Asian J Pharm Clin Res 2013;6 Suppl 3:1974-7.
Thomson HA, Ojo OO, Flatt PR, Abdel-Wahab YH. Aqueous bark extracts of Terminalia arjuna stimulates insulin release, enhances insulin action and inhibits starch digestion and protein glycation in vitro. Austin J Endocrinol Diabetes 2014;1:1001.
Alamin MA, Yagi AI, Yagi SM. Evaluation of antidiabetic activity of plants used in Western Sudan. Asian Pac J Trop Biomed 2015;5:395 402.
Stoilova I, Trifonova D, Marchev A, Stanchev V, Angelova G, Krastanov A. Phytochemical constituents and in vitro anti-diabetic properties of Ziziphus jujubа (Rhamnaceae) Fruits. Int J Pharm Phytochem Res 2017;9:150-8.
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