EVALUATION OF NOOTROPIC ACTIVITY OF ACHYRANTHES ASPERA LEAVES EXTRACT IN WISTAR RATS
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i12.28314Keywords:
Achyranthes aspera, Nootropic, Elevated plus maze, Radial arm mazeAbstract
Objective: The objective of the study was to evaluate the nootropic activity of hydroalcoholic extract of Achyranthes aspera leaves using elevated plus maze and radial arm maze.
Methods: Adult Wistar rats were allotted to three groups; Group 1 served as control, Groups 2 and 3 received 200 mg/kg and 400 mg/kg of AA extract, respectively, orally for 2 weeks after which the extent of improvement of memory was assessed.
Results: AA showed nootropic activity in both elevated plus maze and radial arm maze. 200 mg/kg of AA extract showed better improvement in learning and memory compared to 400 mg/kg.
Conclusions: These results indicate that AA leaves extract clearly exhibited the improvement in learning and memory.
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