INFLUENCE OF FORMULATION PARAMETERS ON DISSOLUTION RATE ENHANCEMENT OF ACYCLOVIR USING LIQUISOLID FORMULATION

Authors

  • Kubota Mwaka Hazemba Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Jivan Jyoti Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Sheetu Wadhwa Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Sananda Som Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Souvik Mohanta Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Ankit Kumar Yadav Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Bimlesh Kumar Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Varun Garg Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Deep Shikha Sharma Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Rubiya Khursheed Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Monica Gulati Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Sachin Kumar Singh Department of Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s2.28537

Keywords:

Acyclovir, Dissolution, Non-volatile liquid, Liquisolid tablets

Abstract

Objective: The objective of this research work is to explore the use of liquisolid technique in enhancement of acyclovir dissolution rate. This current study was planned to assess the impact of different formulation variables, such as non-volatile liquid type and concentrations of acyclovir on its dissolution rates profile.

Method: Acyclovir liquisolid tablets were prepared with Tween 60 (liquid vehicle), Microcrystalline cellulose PH 102 (acted as a carrier to turn liquid medication into free-flowing powder) and Syloid XDP (coating material). In vitro, drug dissolution rate of liquisolid formulations of acyclovir was performed and compared with pure acyclovir drug using USP dissolution apparatus (Type II) for 60 min at a paddle speed of 50 rpm and filled with 900 mL of distilled water.

Results: The dissolution study showed that 94.1% of the drug was released in 60 min of ratio 10 while only 66% of the pure drug acyclovir was released in 60 min. Hence, present work concluded that the acyclovir dissolution rate profile has been improved with the formation of liquisolid formulations.

Conclusion: From the present study, it may be ratified that the drug dissolution rate of acyclovir has been improved with the utilization of liquisolid formulations approach. 

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References

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Published

27-07-2018

How to Cite

Hazemba, K. M., J. Jyoti, S. Wadhwa, S. Som, S. Mohanta, A. K. Yadav, B. Kumar, V. Garg, D. S. Sharma, R. Khursheed, M. Gulati, and S. K. Singh. “INFLUENCE OF FORMULATION PARAMETERS ON DISSOLUTION RATE ENHANCEMENT OF ACYCLOVIR USING LIQUISOLID FORMULATION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 14, July 2018, pp. 36-40, doi:10.22159/ajpcr.2018.v11s2.28537.

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