PHARMACOLOGICAL IMPORTANCE OF MORINGA CONCANENSIS NIMMO LEAF: AN OVERVIEW
DOI:
https://doi.org/10.22159/ajpcr.2019.v12i2.28979Keywords:
Moringa concanensis, Alkaloids, Flavonoids, Terpenoids, Diabetes, Inflammation, ThyroidAbstract
In the current years, the use of traditional medicine is increasing and gaining popularity. The extracts of Moringa concanensis Nimmo leaves have reported many medicinal uses. In the previous few decades, a massive quantity of scientific facts concerning plants, crude extracts, and quite a number supplies from plant life as medicinal dealers has come to light. M. concanensis is a plant whose components are oftentimes used in the medicinal treatments. There are good sized anecdotal facts about the organic undertaking of M. concanensis which includes anticancerous, antibacterial, antifungal, analgesic, and anti-inflammatory type of activities. The leaves of M. concanensis had been located to contain a higher quantity of triterpenoids and flavonoids. The existing assessment includes the phytochemical, ethnopharmacological, and pharmacological reviews of M. concanensis. The future scope of the plant has been emphasized with a view to isolate bioactive moieties which should be used for multifarious biological activities.
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Ragavendran P, Sophia D, Raj CA, Gopikrishnan VK. Functional group analysis of various extracts of Aerva lantata (L.,) by FTIR spectrum. Pharm Online Newslett 2011;1:358-64.
Sandosh TA, Peter MP, Raj JY. Phytochemical analysis of Stylosanthes fruticosa using UV-VIS, FTIR and GC-MS. Res J Chem Sci 2013;3:14 23.
Amani AS, Alothman MR.Zain YM, Alqasoumi SI, Alothman EA. Quantitative and qualitative analysis for standardization of Euphorbia cuneata Vahl. Saudi Pharm J 2017;25:1175-8.
Santhi K, Sengottuvel R. Antibacterial activity of methanolic extracts of Moringa concanensis Nimm. Int J Pharm Bio Sci 2016;7:61-5.
Awodele O, Oreagba IA, Odoma S, da Silva JA, Osunkalu VO. Toxicological evaluation of the aqueous leaf extract of Moringa oleifera lam. (Moringaceae). J Ethnopharm 2012;139:330-6.
Vijayakumar S, Sumathi A, Preliminary phytochemical and GC-MS analysis of bioactive compounds from Moringa concanensis Nimmo leaves family: Moringaceae. Int J Rec Adv Multidiscip Res 2016;3:1257-9.
Balakrishnan BB, Krishnasamy K, Choi KC. Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by upregulating PPAR-?, C/EBP-? via Akt signaling pathway and STZ-induced diabetic rats. Biomed Pharm 2018;103:719-28.
Anbazhakan S, Dhandapani R, Anandhakumar P, Balu S. Traditional medicinal knowledge on Moringa concanensis Nimmo of Perambalur district, Tamilnadu. Anc Sci Life 2007;26:42-5.
Bhamadevi R. Screening of Bioactive Compounds from the leaves of Moringa concanensis Nimmo. Int J Innov Res Sci Eng Technol 2015;4:9702-9.
Santhi K, Sengottuvel R. Qualitative and quantitative phytochemical analysis of Moringa concanensis Nimmo. Int J Curr Microbiol Appl Sci 2016;5:633-40.
Balamurugan V, Balakrishnan V. Evaluation of phytochemical, pharmacognostical and antimicrobial activity from bark of Moringa concanensis Nimmo. Int J Curr Micobiol App Sci 2013;2:117-25.
Gaikwad M, Kale S, Bhandare S, Urunkar V, Rajmane A. Extraction, characterization and comparison of fixed oil of Moringa oleifera L and Moringa concanensis Nimmo Fam. Moringaceae. Int J Pharm Tech Res 2011;3:1567-75.
Arora DS, Onsare JG, Kaur H. Bioprospecting of Moringa (Moringaceae): Microbiological perspective. J Pharm Phytochem 2013;1:193-215.
Available from: http://www.indiabiodiversity.org/species/show/230449. [Last accessed on 2016 Feb 02].
Bagad AS, Joseph JA, Bhaskaran N, Agarwal A. Comparative evaluation of anti-inflammatory activity of curcuminoids, turmerones, and aqueous extract of Curcuma long. Adv Pharm Sci 2013;2013:1-7.
Ghasemian M, Owlia MB. A different look at pulsed glucocorticoid protocols; is high dose oral prednisolone really necessary just after initiation of pulse therapy? J Case Rep Pract 2015;3:1-3.
Ghasemian M, Owlia S, Owlia MB. Review of anti-inflammatory herbal medicines. Adv Pharm Sci 2016;2016:9130979.
Jayabharathi M, Chitra M. Evaluation of anti-inflammatory, analgesic and antipyretic activity of Moringa concanensis Nimmo. J Chem Pharm Res 2011;3:802-6.
Rao CV, Hussain T, Verma AR, Kumar N, Vijaykumar M, Reddy GD. Evaluation of the analgesic and anti-inflammatory activity of Moringa concanensis tender fruits. Asian J Tradit Med 2008;3:95-102.
Schnekenburger M, Dicato M, Diederich M. Plant-derived epigenetic modulators for cancer treatment and prevention. Biotechnol Adv 2014;32:1123-32.
Butler MS, Robertson AA, Cooper MA. Natural product and natural product derived drugs in clinical trials. Nat Prod Rep 2014;31:1612-61.
Hashemzaei M, Barani AK, Iranshahi M, Rezaee R, Tsarouhas K, Tsatsakis AM, et al. Effects of resveratrol on carbon monoxide-induced cardiotoxicity in rats. Environ Toxicol Pharm 2016;46:110-5.
Hashemzaei M, Entezari Heravi R, Rezaee R, Roohbakhsh A, Karimi G. Regulation of autophagy by some natural products as a potential therapeutic strategy for cardiovascular disorders. Eur J Pharm 2017;802:44-51.
DeVita VT Jr. Young RC, Canellos GP. Combination versus single agent chemotherapy: A review of the basis for selection of drug treatment of cancer. Cancer 1975;35:98-110.
Pisani P, Bray F, Parkin DM. Estimates of the world-wide prevalence of cancer for 25 sites in the adult population. Int J Cancer 2002;97:72-81.
Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011;61:212-36.
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer 2013;49:1374-403.
Fridlender M, Kapulnik Y, Koltai H. Plant derived substances with anti-cancer activity: From folklore to practice. Front Plant Sci 2015;6:799.
Karikas GA. Anticancer and chemopreventing natural products: Some biochemical and therapeutic aspects. J BUON 2010;15:627-38.
Balamurugan V, Balakrishnan V, Robinson JP, Ramakrishnan M. Anticancer and apoptosis-inducing effects of Moringa concanensis using hepG2 cell lines. Bangladesh J Pharm 2014;9:604-9.
Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. 5th ed. New Delhi, India: Elsevier Science Ltd.; 2003.
Raquibul SM, Hossain MM, Aktar R, Jamila M, Mazumder ME, Alam MA, et al. Analgesic activity of the different fractions of the aerial parts of Commenila benghalensis Linn. Int J Pharm 2010;6:63-7.
Laurence DR, Benneth PN, Brown MJ. Clinical Pharmacology. 8th ed. Edinburgh: Church Hill Livingstone; 1997.
Mate GS, Naikwade NS, Chowki CS, Patil SB. Evaluation of anti-nociceptive activity of Cissus quadrangularis on Albino mice. Int J Green Pharm 2008;2:118-21.
Ezeja M, Omeh Y, Ezeigbo I, Ekechukwu A. Evaluation of the analgesic activity of the methanolic stem bark extract of Dialium guineense (wild). Ann Med Health Sci Res 2011;1:55-62.
Zeisberger E. From humoral fever to neuroimmunological control of fever. J Therm Biol 1999;24:287-326.
Roth J. Endogenous antipyretics. Clin Chim Acta 2006;371:13-24.
Ashok BK, Ravishankar B, Prajapati PK, Bhat SD. Antipyretic activity of guduchi ghrita formulations in albino rats. Ayu 2010;31:367-70.
Londonkar R, Nayaka HB. Evaluation of anti-implantation and abortificient properties of Portulaca oleracea L. In albino rats. Int J Pharm Bio Sci 2011;2:501-8.
Adhikary P, Banerji J, Chowdhury D, Das A, Deb CC, Mukherje SR, et al. Antifertility effect of Piper betle Linn, extract on ovary and testis of albino rats. Ind J Exp Biol 1989;27:868-70.
Ahmed B, Garg D. Antifertility activity of emerginatosides B and C of fruits of Sapindus emerginatus. J Med Arom Plant Sci 1998;20:362-6.
Shukla S, Mathur R, Prakash AO. Anti-implantation efficacy of Moringa concanensis Nimmo in rats. Int J Crude Drug Res 2008;26:29 32.
Buznego MT, Pérez-Saad H. Acute effect of an extract of Ambrosia paniculata (Willd.) O. E. Schultz (mugwort) in several models of experimental epilepsy. Epilepsy Behav 2004;5:847-51.
Spinella M. Herbal medicines and epilepsy: The potential for benefit and adverse effects. Epilepsy Behav 2001;2:524-32.
Hedge IC. A global survey of the biogeography of the Labiatae. In: Harley RM, Reynolds T, editors. Advances in Labiatae Science. London: Royal Botanical Gardens; 1992. p. 7-17.
Naghibi F, Mosaddegh M, Mohammadi S, Ghorbani A. Labiatae family in folk medicine in Iran: From ethnobotany to pharmacology. Iran J Pharm Sci 2005;2:63-79.
Richardson P. The chemistry of the Labiatae: An introduction and overview. In: Harley RM, Reynolds T, editors. Advances in Labiatae Science. London: Royal Botanical Garden; 1992. p. 291-7.
Khoshnood-Mansoorkhani MJ, Moein MR, Oveisi N. Anticonvulsant activity of Teucrium polium against seizure induced by PTZ and MES in mice. Iran J Pharm Res 2010;9:395-401.
Joy AE, Kunhikatta SB, Manikkoth S. Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice. Arch Med Health Sci 2015;1:6-9.
Farnsworth NR. Ethno pharmacology and future drug development: The North American experience. J Ethnopharm 1993;38:145-52.
Houghton PJ. The role of plants in traditional medicine and current therapy. J Alter Complement Med 1995;1:131-43.
Dubey NK, Kumar R, Tripathi P. Global promotion of herbal medicines: India’s opportunity. Curr Sci 2004;86:37-41.
Cragg GM, Newman DJ. Biodiversity: A continuing source of novel drug leads. Pure Appl Chem 2005;77:7-24.
Lam KS. New aspects of natural products in drug discovery. Trends Microbiol 2007;15:279-89.
Runyoro DK, Matee MI, Ngassapa OD, Joseph CC, Mbwambo ZH. Screening of Tanzanian medicinal plants for anti-candida activity. BMC Complement Altern Med 2006;6:11.
Shahidi BH. Evaluation of antimicrobial properties of Iranian medicinal plants against Micrococcus luteus, Serratia marcescens, Klebsiella pneumonia and Bordetella bronchoseptica. Asian J Plant Sci 2004;3:82-6.
Reddy PS, Jamil K, Madhusudhan P. Antibacterial activity of isolates from Piper longum and Taxus baccata. Pharm Biol 2001;39:236-8.
Maheshwari JK, Singh KK, Saha S. Economic Botany Information Service, NBRI. Lucknow: Ethno botany of tribals of Mirzapur District, Uttar Pradesh; 1986.
Dahanukar SA, Kulkarni RA, Rege NN. Pharmacology of medicinal plants and natural products. Indian J Pharm 2000;32:S81-118.
Cowan MM. Plant products as antimicrobial agents. Clin Microbiol Rev 1999;12:564-82.
Ashwoth A, Christopher J, Reis-Filho S. Genetic interaction in cancer progression and Bull Cell 2011;145:30-8.
Graidist P, Martla M, Sukpondma Y. Cytotoxic activity of Piper cubeba extract in breast cancer cell lines. Nutrients 2015;7:2707-18.
Thun MJ, DeLancey JO, Center MM, Jemal A, Ward EM. The global burden of cancer: Priorities for prevention. Carcinogenesis 2010;31:100-10.
Bingham S, Riboli E. Diet and cancer – the European prospective investigation into cancer and nutrition. Nat Rev Cancer 2004;4:206-15.
Farshori NN, Al-Sheddi ES, Al-Oqail MM, Musarrat J, Al-Khedhairy AA, Siddiqui MA, et al. Anticancer activity of Petroselinum sativum seed extracts on MCF-7 human breast cancer cells. Asian Pac J Cancer Prev 2013;14:5719-23.
Adhami VM, Aziz MH, Mukhtar H, Ahmad N. Activation of pro death Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCa T keratinocytes. Clin Cancer Res 2003;9:3176-82.
Sak K. Cytotoxicity of dietary flavonoids on different human cancer types. Pharm Rev 2014;8:122-46.
Gulcin I, Alici HA, Cesur M. Determination of in vitro antioxidant and radical scavenging activities of propofol. Pharm Bull 2005;53:281-5.
Terao J, Piscula M, Yao MC. Protective effect of epicatechin, epicatechin gallate and quercetin on lipid peroxidation in phoshpolipid bilayers. Arch Biochem Biophy 1994;308:278-84.
Farber JL. Mechanisms of cell injury by activated oxygen species. Environ Health Pers 1994;102:17-24.
Hogg N. Free radicals in disease. Semin Reprod Endocrin 1998;162:41 88.
Marchioli R, Schweiger C, Levantes G, Tavazzi L, Valagussa F. Antioxidant vitamins and prevention of cardiovascular disease: Epidemiological and clinical trial data. Int J Pharm Sci Rev Res 2001;36:53-63.
Robak J, Marcinkiewicz E. Scavenging of reactive oxygen species as the mechanism of drug action. Pol J Pharmacol 1995;47:89-98.
Madhavi DL, Salunkhe DK, Deshpande SS. Toxicological Aspects of Food Antioxidants. New York: Food Antioxidants; 1995. p. 267.
Vijayakumar S, Bhuvaneshwari V, Sumathi A. Antioxidant and anticancer potential of methanolic leaf extract of Moringa concanensis Nimmo against human breast cancer cell line MCF-7. Int J Pharm Phytochem Res 2017;9;750-4.
Singh SN, Vats P, Suri S, Shyam R, Kumria MM, Ranganathan S, et al. Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. J Ethnopharm 2001;76:269-77.
Gupta R, Mathur M, Bajaj VK, Katariya P, Yadav S, Kamal R, et al. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J Diabetes 2012;4:164-71.
Atmakuri LR, Dathi S. Current trends in herbal medicines. J Pharm Res 2010;3:109-13.
Amod A, Ascott-Evans BH, Berg GI, Blom DJ, Brown SL, Carrihill MM. The 2012 SEMDSA guideline for the management of type 2 diabetes (Revised). J Endocrinol Metab Diabetes South Afr 2012;17:1 95.
Dièye AM, Sarr A, Diop SN, Ndiaye M, Sy GY, Diarra M, et al. Medicinal plants and the treatment of diabetes in Senegal: Survey with patients. Fundam Clin Pharm 2008;22:211-6.
Efiong EE, Igile GO, Mgbeje BIA, Otu EA, Ebong PE. Hepatoprotective and anti-diabetic effect of combined extracts of Moringa oleifera and Vernonia amygdalina in streptozotocin-induced diabetic albino wistar rats. Glob J Hematol Endocr 2013;1:5-10.
Ayepola OR., Brooks NL, Oguntibeju OO. Kolaviron improved resistance to oxidative stress and inflammation in the blood (erythrocyte, serum, and plasma) of streptozotocin-induced diabetic rats. Sci World J 2014;2014:1-8.
Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed 2012;2:320-30.
Singh BN, Singh BR, Singh RL, Prakash D, Dhakarey R, Upadhyay G, et al. Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera. Food Chem Toxicol 2009;47:1109-16.
Shanker K, Gupta M, Srivastava S, Bawankule D, Pal A, Khanuja SP. Determination of bioactive nitrile glycoside(s) in drumstick (Moringa oleifera) by reverse phase HPLC. Food Chem 2007;105:376-82.
Prod JN, Resour P, Mensah JK, Ikhajiagbe B, Edema NE, Emokhor J. Phytochemical, nutritional and antibacterial properties of dried leaf powder of Moringa oleifera (Lam) from Edo Central Province, Nigeria. J Nat Prod Plant Resour 2012;2:107-12.
Soliman GZ. Anti-diabetic activity of dried Moringa oleifera leaves in normal and streptozotocin (stz) - Induced diabetic male rats. Indian J Appl Res 2013;3:18-23.
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