THE HEMOSTATIC ACTIVITY OF BIS (2-AMINOETHAN-1-SULFONATE) CALCIUM

Authors

  • Konstantin G Gurevich UNESCO Chair Healthy Lifestyle - the Key to Successful Development,” Moscow State University of Medicine and Dentistry named after A. I. Evdakimov, Moscow, Russia.
  • Aleksandr L Urakov Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Izhevsk, Russia.
  • Linara I Bashirova Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Izhevsk, Russia.
  • Aleksandr V Samorodov Departement of Anesthesiology, Bashkir State Medical University, Ufa, Russia.
  • Peter P Purygin Departement of Organic Chemistry, Samara National Research University N.A. Academician S.P. Korolev, Samara, Russia.
  • Vladimir A Yermokhin Departement of Organic Chemistry, Samara National Research University N.A. Academician S.P. Korolev, Samara, Russia.
  • Alfiya S Gilmutdinova Departement of Organic Chemistry, Samara National Research University N.A. Academician S.P. Korolev, Samara, Russia.
  • Nataliia A Bondareva Departement of Organic Chemistry, Samara National Research University N.A. Academician S.P. Korolev, Samara, Russia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i11.29049

Keywords:

Taurate of calcium, Hemostasis system, Proaggregatory activity, Hemostatic activity

Abstract

Objective: It is known that local or systemic injection of hemostatic drugs is used to reduce blood loss and number of blood transfusions in patients with hypocoagulation and hemorrhagic diathesis. However, the analysis of literature data shows that the drugs applied for the control of bleeding, traditionally used in medical practice, are not effective enough. This study deals with the systemic hemostatic activity of bis (2-aminoethan-1- sulfonate) calcium in the experiment.

Methods: Experimental work in vitro is performed on the blood of healthy male donors, under conditions in vivo it is done on intraperitoneal injection in male rats. Thromboelastography was carried out with apparatus Thromboelastography (TEG) 5000 (Haemoscope Corporation, United States). The influence of first synthesized derivative and ethamsylate on functional activity of platelets was studied using a platelet aggregation analyzer Biola 230LA†(Russia). Experimental evaluation of the system specific hemostatic activity in vivo was carried out using the model of parenchymatous bleeding in mature male rats. The interference came amid registration of bleeding stop time and extent of blood loss.

Results: Bis (2-aminoethan-1-sulfonate) calcium shows procoagulation and proaggregant activity both in vitro and in vivo. Proaggregatory effect of bis (2-aminoethan-1-sulfonate) calcium is successfully implemented in the systemic hemostatic activity in terms of parenchymal bleeding, surpassing the control group and the group of etamsylate.

Conclusion: The results of these studies reveal potentially high systemic hemostatic activity of bis (2-aminoethan-1-sulfonate) calcium, urging the need for further study on this compound and its analogs to create on their basis highly efficient, selective correctors of the hemostatic system.

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Author Biographies

Konstantin G Gurevich, UNESCO Chair Healthy Lifestyle - the Key to Successful Development,” Moscow State University of Medicine and Dentistry named after A. I. Evdakimov, Moscow, Russia.

MD, Professor, Head of the UNESCO Chair "Healthy Lifestyle - the Key to Successful Development"

Aleksandr L Urakov, Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Izhevsk, Russia.

MD, Professor, Head of the Department of General and Clinical Pharmacology

Linara I Bashirova, Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Izhevsk, Russia.

post-graduate student, Department of General and Clinical Pharmacology

Aleksandr V Samorodov, Departement of Anesthesiology, Bashkir State Medical University, Ufa, Russia.

PhD, assistant professor, Departement of Anesthesiology

Peter P Purygin, Departement of Organic Chemistry, Samara National Research University N.A. Academician S.P. Korolev, Samara, Russia.

Professor, Head of the Departement of Organic Chemistry

Vladimir A Yermokhin, Departement of Organic Chemistry, Samara National Research University N.A. Academician S.P. Korolev, Samara, Russia.

PhD, assistant professor, Departement of Organic Chemistry

Alfiya S Gilmutdinova, Departement of Organic Chemistry, Samara National Research University N.A. Academician S.P. Korolev, Samara, Russia.

post-graduate student, Departement of Organic Chemistry

Nataliia A Bondareva, Departement of Organic Chemistry, Samara National Research University N.A. Academician S.P. Korolev, Samara, Russia.

post-graduate student, Departement of Organic Chemistry

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Published

07-11-2018

How to Cite

Gurevich, K. G., A. L Urakov, L. I Bashirova, A. V Samorodov, P. P Purygin, V. A Yermokhin, A. S Gilmutdinova, and N. A Bondareva. “THE HEMOSTATIC ACTIVITY OF BIS (2-AMINOETHAN-1-SULFONATE) CALCIUM”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 11, Nov. 2018, pp. 452-5, doi:10.22159/ajpcr.2018.v11i11.29049.

Issue

Vol 11 Issue 11 November 2018

Section

Original Article(s)

The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.

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