STUDY OF PANEL OF DIAGNOSTIC CARDIAC MARKERS FOR ACUTE MYOCARDIAL INFARCTION

ANOOP KUMAR; PREETI SHARMA; PRADEEP KUMAR; ASHOK KUMAR

doi:10.22159/ajpcr.2019.v12i3.29560

Authors

ANOOP KUMAR Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India,
PREETI SHARMA Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India,
PRADEEP KUMAR Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India,
ASHOK KUMAR Department of Medicine, Santosh Medical College and Hospital, Ghaziabad.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i3.29560

Keywords:

Myocardial, Troponin, Dehydrogenase

Abstract

Objectives: The aim of this study is to estimate the level of creatine kinase-myocardial band (CK-MB), C-reactive protein (CRP), and lactate dehydrogenase (LDH) biomarker in myocardial infarction (MI) (troponin T-positive) and compare with normal healthy individuals (Troponin-T [TnT] negative).

Methods: A cross-sectional study on 172 patients involving 100 patients with nondiabetic MI and 72 apparently healthy controls with no history of diabetes and/or MI was done from December 2017 to May 2018. The diagnosis of MI was established with electrocardiogram findings and TnT estimation. Blood samples were gathered and processed for the estimation of CK-MB, LDH, and CRP.

Results: The mean age of the cases was 62.15±7.75 years and in the controls was 61.49±8.35 years (p=0.592). The mean value of CK-MB, LDH, and CRP in the TnT positive group was 111.94±29.59 IU/L, 564.43±110.99 IU/L, and 15.69±4.04 mg/L, whereas in the TnT negative group was 16.36±3.77 IU/L, 223.68±36.23 IU/L, and 6.08±2.02 mg/L, respectively (p<0.0001). CK-MB was deranged in 100% of TnT positive group, and in only 2.78% in TnT negative group (p<0.0001). LDH was deranged in 100% TnT positive group, and in 16.67% in TnT negative group (p<0.0001). CRP was deranged in 4% TnT positive group, and in 0% in TnT negative group (p=0.141).

Conclusion: This study indicated that CK-MB and LDH are sensitive cardiac markers for the diagnosis of MI.

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Author Biography

ANOOP KUMAR, Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India,

Associate Professor, Department of Biochemistry.

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