PREPARATION OF MUCOADHESIVE GASTRORETENTIVE DRUG DELIVERY SYSTEM OF ALGINATE BEADS CONTAINING TURMERIC EXTRACT AND ANTI-GASTRIC ULCER ACTIVITY

Hakim Bangun; Fadlina Aulia; Anayanti Arianto; Marline Nainggolan

doi:10.22159/ajpcr.2019.v12i1.29715

Authors

Hakim Bangun Department of Pharmaceutical Technology, Faculty of Pharmacy, Nanomedicine Centre of Innovation, University of Sumatera Utara, Medan, Indonesia.
Fadlina Aulia Department of Pharmaceutical Technology, Faculty of Pharmacy, Nanomedicine Centre of Innovation, University of Sumatera Utara, Medan, Indonesia.
Anayanti Arianto Department of Pharmaceutical Technology, Faculty of Pharmacy, Nanomedicine Centre of Innovation, University of Sumatera Utara, Medan, Indonesia.
Marline Nainggolan Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i1.29715

Keywords:

Turmeric extract, Alginate beads, Mucoadhesive, Gastroretentive, Anti-gastric ulcer

Abstract

Objectives: The objectives of this study were to prepare the mucoadhesive mucoadhesive gastroretentive drug delivery system of alginate beads containing turmeric extract and to evaluate its anti-gastric effect.

Methods: Turmeric extract was made by macerating turmeric powder in ethanol 96% and evaporated using rotary evaporator at 50Â°C to obtained concentrated extract. Then, it was prepared alginate beads containing 5% turmeric extract by gelation method. The mucoadhesive properties of alginate beads containing turmeric extract were tested in vitro in male rats and the anti-gastric ulcer effect was tested on HCl-induced gastric ulcer in rats.

Results: The mean diameter of alginate beads obtained was 1.13Â±0.19 mm. Bioadhesion test showed that alginate beads containing turmeric extract could be attached on gastric rats mucosa. Anti-gastric ulcer test showed that the healing of gastric lesions in rats was faster using alginate beads containing turmeric extract compared to untreated ones.

Conclusions: The results of this study suggest that mucoadhesive drug delivery systems of alginate beads containing turmeric extract are potentially developed as an anti-gastric ulcer.

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