ANTI-HYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF BOESENBERGIA PANDURATA (FINGER ROOT) IN EXPERIMENTAL INDUCED HYPERCHOLESTROLEMIC SPRAGUE DAWLEY RATS
Keywords:Anti-hyperlipidemia, Hypercholesterolemia, Statins, Finger root (Boesenbergia pandurata)
Objective: Hyperlipidemia is one of the risk factors that contribute to the prevalence of coronary heart diseases and antihyperlipidemic agents, such as statin, was used to treat hyperlipidemia as a current therapy. Boesenbergia pandurata has not been exploited for antihyperlipidemic effect. Hence, this study aims to screen for the antihyperlipidemic activity of methanolic extracts of B. pandurata rhizomes (BPR extracts) in hypercholesterolemia-induced Sprague-Dawley rats.
Methods: BPR extracts were prepared using the maceration method with 1500 ml of 80% methanol at room temperature for about 7 days. A toxicity study was carried out based on OECD guidelines. Hypercholesterolemia was induced by 6% lard oil, 2% of cheese, and egg yolks. Two different doses of BPR extracts, 200 and 400 mg/kg, were used to screen for antihyperlipidemic effect. Histopathological study was carried out in the liver. The results were evaluated for the statistically significant difference by using the one-way ANOVA followed by post hoc Dunnett test.
Results: No mortality was witnessed even till 2 g/kg. Only 400 mg/kg of BPR extracts statistically reduced in total cholesterol (p<0.05), low-density lipoprotein-cholesterol (p<0.05) and an increase in high-density lipoprotein-cholesterol (p<0.05) when compared to the positive control. BPR extracts (400 mg/kg) showed less enlargement of lipid droplets as compared to positive control.
Conclusion: BPR extracts can be a promising medicinal plant for treating hyperlipidemia in underdeveloped countries.
Sudha SS, Karthic R, Naveen, Rengaramanujam J. Anti hyperlipidemic activity of Spirulina platensis in triton x-100 induced hyperlipidemic rats. Hygeia J D Med 2011;3:32-7.
Katzung BG, Masters SB, Trevor AJ. Basic and Clinical Pharmacology. New York: McGraw-Hill Medical; 2012.
Girija K, Lakshman K. Anti-hyperlipidemic activity of methanol extracts of three plants of Amaranthus in triton-WR 1339 induced hyperlipidemic rats. Asian Pac J Trop Biomed 2011;1:S62-5.
Subramaniam S, Ramachandran S, Uthrapathi S, Gnamanickam VR, Dubey GP. Anti-hyperlipidemic and antioxidant potential of different fractions of Terminalia arjuna roxb. Bark against PX- 407 induced hyperlipidemia. Indian J Exp Biol 2011;49:282-8.
Rao BS, Srinivasa B, Desu R, Saileela C. Anti-hyperlipidemic activity of methanolic extract of Rhinacanthus nasutus. Int J Res Pharm Chem 2013;3:708-11.
Cheenpracha S, Karalai C, Ponglimanont C, Subhadhirasakul S, Tewtrakul S. Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata. Bioorg Med Chem 2006;14:1710-4.
Abdelwahab SI, Mohan S, Abdulla MA, Sukari MA, Abdul AB, Taha MM, et al. The methanolic extract of Boesenbergia rotunda (L.) mansf. And its major compound pinostrobin induces anti-ulcerogenic property in vivo: Possible involvement of indirect antioxidant action. J Ethnopharmacol 2011;137:963-70.
Balasubramanian MN, Muralidharan P, Balamurugan G. Anti hyperlipidemic activity of Pedalium murex (linn.) fruits on high fat diet fed rats. Int J Pharmacol 2008;4:310-3.
Dhulasavant V, Shinde S, Pawar M, Naikwade NS. Antihyperlipidemic activity of Cinnamomum tamala nees. on high cholesterol diet induced hyperlipidemia. Int J PharmTech Res 2010;2:2517-21.
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