ANTI-HYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF BOESENBERGIA PANDURATA (FINGER ROOT) IN EXPERIMENTAL INDUCED HYPERCHOLESTROLEMIC SPRAGUE DAWLEY RATS

Santosh Fattepur; Kiran Chanabasappa Nilugal; Ranya Rajendran; Fadli Asmani; Eddy Yusuf

doi:10.22159/ajpcr.2018.v11s3.29962

Authors

Santosh Fattepur Department of Pharmacology, School of Pharmacy, Management and Science University Shah Alam, Selangor, Malaysia.
Kiran Chanabasappa Nilugal Department of Pharmacology, School of Pharmacy, Management and Science University Shah Alam, Selangor, Malaysia.
Ranya Rajendran Department of Pharmacology, School of Pharmacy, Management and Science University Shah Alam, Selangor, Malaysia.
Fadli Asmani Department of Clinical pharmacy, School of Pharmacy, Management and Science University Shah Alam, Selangor, Malaysia.
Eddy Yusuf Department of Clinical pharmacy, School of Pharmacy, Management and Science University Shah Alam, Selangor, Malaysia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s3.29962

Keywords:

Anti-hyperlipidemia, Hypercholesterolemia, Statins, Finger root (Boesenbergia pandurata)

Abstract

Objective: Hyperlipidemia is one of the risk factors that contribute to the prevalence of coronary heart diseases and antihyperlipidemic agents, such as statin, was used to treat hyperlipidemia as a current therapy. Boesenbergia pandurata has not been exploited for antihyperlipidemic effect. Hence, this study aims to screen for the antihyperlipidemic activity of methanolic extracts of B. pandurata rhizomes (BPR extracts) in hypercholesterolemia-induced Sprague-Dawley rats.

Methods: BPR extracts were prepared using the maceration method with 1500 ml of 80% methanol at room temperature for about 7 days. A toxicity study was carried out based on OECD guidelines. Hypercholesterolemia was induced by 6% lard oil, 2% of cheese, and egg yolks. Two different doses of BPR extracts, 200 and 400 mg/kg, were used to screen for antihyperlipidemic effect. Histopathological study was carried out in the liver. The results were evaluated for the statistically significant difference by using the one-way ANOVA followed by post hoc Dunnett test.

Results: No mortality was witnessed even till 2 g/kg. Only 400 mg/kg of BPR extracts statistically reduced in total cholesterol (p<0.05), low-density lipoprotein-cholesterol (p<0.05) and an increase in high-density lipoprotein-cholesterol (p<0.05) when compared to the positive control. BPR extracts (400 mg/kg) showed less enlargement of lipid droplets as compared to positive control.

Conclusion: BPR extracts can be a promising medicinal plant for treating hyperlipidemia in underdeveloped countries.

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