BIOMARKER POTENTIAL OF IQ-DOMAIN GTPASE-ACTIVATING PROTEINS FAMILY PROTEIN IN PANCREATIC CANCER: A MINI REVIEW

Anton Sumarpo; Agnes Anania Triavika Sahamastuti; Gisella Edny Tjugianto; Kenny Yonathan; David Agustriawan

doi:10.22159/ajpcr.2018.v11s3.30021

Authors

Anton Sumarpo Department of Biochemistry, Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Agnes Anania Triavika Sahamastuti Department of Pharmacy, Indonesia International Institute for Life Sciences, Jakarta, Indonesia.
Gisella Edny Tjugianto Department of Pharmacy, Indonesia International Institute for Life Sciences, Jakarta, Indonesia.
Kenny Yonathan Department of Biomedicine, Indonesia International Institute for Life Sciences, Jakarta, Indonesia.
David Agustriawan Department of Bioinformatics, Indonesia International Institute for Life Sciences, Jakarta, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s3.30021

Keywords:

Pancreatic cancer, IQ-domain GTPase-activating proteins, Tumor biomarker, Early detection, Prognostic value

Abstract

Objectives: Our present study was done to understand molecular regulatory mechanisms of IQGAP proteins and their potentials as biomarker in pancreatic cancer.

Methods: In this review, relevant studies were obtained by assessing the PubMed database using the combination of words that included IQGAPâ€ and pancreatic cancerâ€.

Results: There is an increasing evidence showing that the expression of IQGAP1 and IQGAP3 is positively correlated with tumorigenesis; however, IQGAP2 might play a role to suppress tumor progression.

Conclusion: IQGAP proteins might have potentials as predictive and prognostic biomarker for human pancreatic cancer.

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