ANTI-METALOTOXIC PROPERTIES OF KELAKAI (STENOCHLAENA PALUSTRIS) LEAVES EXTRACT AGAINST CADMIUM-INDUCED LIVER TISSUE DAMAGE

Agung Biworo; Nurul Ainun Azizi; Rizki Padelia; Muhammad Andino Raharja; Ozanata Azima; Eko Suhartono

doi:10.22159/ajpcr.2018.v11s3.30028

Authors

Agung Biworo Department of Pharmacology, Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Nurul Ainun Azizi Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Rizki Padelia Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Muhammad Andino Raharja Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Ozanata Azima Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.
Eko Suhartono Department of Medical Chemistry/ Biochemistry, Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s3.30028

Keywords:

Cadmium, Liver, Oxidative Stress, Stenochlaena palustris

Abstract

Objective: The present study was undertaken to investigate the anti-metalotoxic activity of the leaves extract of Stenochlaena palustris (kelakai; S. palsutris) on cadmium (Cd)-induced liver tissue damage.

Methods: Liver tissue damage was induced by the administration of cadmium sulfate (CdSO4) at a dose 3 mg/l. Anti-metalotoxic effect of the extracts was determined by assessing the concentration of malondialdehyde (MDA), carbonyl compound (CC), conjugated dienes (CD), and advanced oxidation protein products (AOPPs) induced by Cd with and without the presence of the extract.

Results: The results of this present studies showed that treatment with CdSO4 significantly increase the levels of MDA, CC, CD, and AOPPs. The leaves extract of S. palustris significantly decrease the levels of all measured parameter in liver tissue.

Conclusion: The present study demonstrated that Cd could induced the liver tissue damage, and the extract of S. palsutris showed the anti-metalotoxic activity to reduce the damage.

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