PREPARATION AND EVALUATION OF ULTRASOUND TRANSMISSION GEL

Amina M Al-nima; Myasar Al-kotaji; Osamah Al-iraqi; Zahraa H Ali

doi:10.22159/ajpcr.2019.v12i1.30150

Authors

Amina M Al-nima Department of Pharmaceutics, College of Pharmacy, Mosul University, Mosul, Iraq.
Myasar Al-kotaji Department of Pharmaceutics, College of Pharmacy, Mosul University, Mosul, Iraq.
Osamah Al-iraqi Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Mosul, Mosul, Iraq.
Zahraa H Ali Department of Pharmaceutics, College of Pharmacy, Mosul University, Mosul, Iraq.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i1.30150

Keywords:

Carbopol 934, Gel, Transmission test, Ultrasonography, Nil

Abstract

Objective: Formulation of an alternative ultrasound transmission gel that is of good quality using the available chemicals in Iraqi market and without any harmful effects to skin.

Methods: Four formulas G1, G2, G3, and G4 with different Carbopol 934 concentrations (0.3, 0.4, 0.5, and 0.6) w/v%, respectively, were prepared and evaluated for different physicochemical characteristics including: Clarity, homogeneity, density, pH, viscosity, and spreadability tests. Other evaluations including skin irritation, microbiological, and stability tests were also performed for the selected formula along with a comparison study with the commercially available ultrasound gel (commercial gel [CG]) which was used as a control. In addition, transmission test was carried out by comparing the transmission between (CG) and (G1) with the assistance of three veterinary radiologists who did ultrasonography of bovine liver for 11 adult cattle breed, aged 3â€“8 years. The three veterinary radiologists were given 33 data sheets to collect results.

Results: Among all the prepared formulas (G1), the formula was considered the best, due to its high clarity, very good homogeneity; its pH was equal to 6.8 which is near to skin pH. Other parameters such as density, viscosity, torque percent, and spreadability showed no significant difference (pâ‰¤0.05) with CG. Skin irritation test which was conducted on animals and humans showed no any adverse effects on skin. Microbiological test manifested that using methylparaben alone was sufficient to prevent the growth of microbes in the gel. The three veterinary radiologists found no significant difference (pâ‰¤0.05) between G1 and CG formulations. Stability study indicated that the gel was stable after storage at room temperature for 3 months.

Conclusion: The overall results suggest that the selected formula (G1) can be considered a successful ultrasound gel and can be used as a good and cheap alternative of the marketed imported gel.

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References

Atlas of Ultrasound-Guided Procedures in Interventional Pain. Narouze SN, editor. Toronto, Canada: Springer Science Business Media, LLC; 2011.

Basic Physics. WHO Manual of Diagnostic Ultrasound. 2nd ed. Geneva, Switzerland: World Health Organization Press; 2011. p. 3-4.

Oâ€™Rourke M, Levan P, Khan T. Current use of ultrasound transmission gel for transesophageal echocardiogram examinations: A survey of cardiothoracic anesthesiology fellowship directors. J Cardiothorac Vasc Anesth 2014;28:1208-10.

Binkowski A, Riguzzi C, Price D, Fahimi J. Evaluation of a cornstarch-based ultrasound gel alternative for low-resource settings. J Emerg Med 2014;47:e5-9.

Garcia-Miguel J, Lamas-DomÃ©nech N, BarcelÃ³-Garcia P. Allergic contact dermatitis in medical professionals due to exposure to ultrasound gel. Reumatol Clin 2016;12:115-6.

Chasset F, Soria A, Moguelet P, Mathian A, Auger Y, FrancÃ¨s C, et al. Contact dermatitis due to ultrasound gel: A case report and published work review. J Dermatol 2016;43:318-20.

Sekar M, Ali A, Subramanian GS, Manoharan VS, Jason JI, Yean PA. Formulation and evaluation of natural ultrasound gel for physiotherapy treatment. Indo Am J Pharm Sci 2017;4:2548-54.

Nanda S, Saroha K, Sharma B. Formulation, evaluation and optimization of transdermal gel of ketorolac tromethamine using face centered central composite design. Int J Pharm Pharm Sci 2014;6:133 9.

Helal DA, El-Rhman DA, Abdel-Halim SA, El Nabarawi MA. Formulation and evaluation of fluconazole topicl gel. Int J Pharm Pharm Sci 2012;4 Suppl 5:176-83.

Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients. 6th ed. UK, USA: Pharmaceutical Press; 2009.

Kaur D, Raina A, Singh N. Formulation and evaluation of carbopol 940 based glibenclamide transdermal gel. Int J Pharm Pharm Sci 2014;6:434-40.

Lee JS, Song KW. Rheological characterization of carbopol 940 in steady shear and start-up flow fields. Annu Trans Nord Rheol Soc 2011; 19: 609-753.

Desai DD, Schmucker JF, Light D. CarbopolUltrez 10 Polymer: A New Universal Thickener fort the Personal Care Industry. Clevelend: Noveon, the Lubrizol Corporation; 2006.

Gaikwad VL, Yadav VD, Dhavale RP, Choudhari PB, Jadhav SD. Effect of carbopol 934 and 940 on fluconazole release from topical gel formulation: A factorial approach. CPR 2012;2:487-93.

Gardouh AR, Ghorab M, Badawy S, Gales RB. Preparation and characterization of mucoadhesive buccal film for delivery of meloxicam. Br J Pharm Res 2013;3:743-66.

Esmaeel ST. Formulation and Evaluation of Nystatin Microspheres as a Topical Dosage Form MSc Thesis. Pharmacy Collage, University of Mosul; 2017. p. 40-6.

Patil S, Kadam A, Bandgar S. Formulation and evaluation of an in situ gel for ocular drug delivery of anti conjunctival drug. Cellulose Chem Technol 2015;49:35-40.

Prasanthi D, Lakshmi PK. Optimisation of transdermal gel formulations of tolterodine tartrate by experimental design. Turk J Pharm Sci 2013;10:273-86.

Nawaz A, Jan SU, Khan NR, Hussain A, Khan GM. Formulation and in vitro evaluation of clotrimazole gel containing almond oil and tween 80 as penetration enhancer for topical application. Pak J Pharm Sci 2013;26:617-22.

United States Pharmacopeial Convention. USP 30 NF 25. 30th ed. Mexico: United States Pharmacopeial Convention; 2007. p. 365-490.

Jadhav VD, Swati GT, Akshada AB, Chaudhari GN. Formulation and evaluation of herbal gel containing leaf extract of Tridax Procumbens. J Pharm BioSci 2015;3:65-72.

Shukr MH, Metwally GF. Evaluation of topical gel bases formulated with various essential oils for antibacterial activity against methicillin-resistant Staphylococcus aureus trop. J Pharm Res 2013;12:877-84.

Hussain A, Khan GM, Shah SU, Shah KU, Rahim N, Wahab A, et al. Development of a novel ketoprofen transdermal patch: Effect of almond oil as penetration enhancers on in-vitro and ex-vivo penetration of ketoprofen through rabbit skin. Pak J Pharm Sci 2012;25:227-32.

Chakole CM, Shende MA, Khadatkar SN. Formulation and development of novel combined halobetasol propionate and fusidic acid ointment. Int J Chem Tech Res 2009;1:103-6.

Khullar R, Kumar D, Seth N, Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharm J 2012;20:63 7.

Shende V, Telrandhe R. Formulation and evaluation of tooth gel from Aloe vera leaves extract. Int J Pharm Drug Anal 2017;5:394-8.

Braun U. Ultrasonography of the liver in cattle. Vet Clin North Am Food Anim Pract 2009;25:591-609, Table of Contents.

Riguzzi C, Binkowski A, Butterfield M, Sani F, Teismann N, Fahimi J, et al. A randomised experiment comparing low-cost ultrasound gel alternative with commercial gel. Emerg Med J 2017;34:227-30.

Chaudhary H, Rohilla A, Rathee P, Kumar V. Optimization and formulation design of carbopol loaded piroxicam gel using novel penetration enhancers. Int J Biol Macromol 2013;55:246-53.

Laxmi RJ, Karthikeyan R, Babu PS, Babu RV. Formulation and evaluation of antipsoriatic gel using natural excipients. J Acute Dis 2013;1:115-21.

Kim JU, Song JY, Park SK, Lee EJ. Rheological properties and microstructures of carbopol gel network system. Colloid Polym Sci 2003;281:614-23.