ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF TECTONA GRANDIS LINN. IN ALLOXAN INDUCED ALBINO RATS
Abstract
Objective: To evaluate the in vivo antioxidant and antidiabetic activity of the methanolic bark extract of Tectona grandis Linn. (Family: Verbenaceae). Methods: The albino rats divided into four groups (Normal, Diabetic control, Diabetic+TGM (150mg) and Diabetic+TGM(300mg)) and the diabetic was induced by alloxan (120mg/kg i.p) and treated with TGM for 20 days. Then the antioxidant and antidiabetic parameters were evaluated by standard protocol. Results: The altered parameters i.e., blood glucose, glycosylated hemoglobin, protein, total cholesterol, urea, Serum creatinine, Aspartate Transaminase (AST), Alanine Transaminase (ALT), Lactate Dehydrogenase (LDH), Thiobarbituritic acid resactive substances (TBARS), Superoxide dismutase (SOD), Catalase and Glucose 6 phosphatase (G6P) were significantly (p<0.05) significantly (p<0.05) controlled by TGM (300mg/kg). Conclusion: The methanolic bark extract of Tectona grandis Linn. showed potent antioxidant and antidiabetic in alloxan induced diabetic rats and it can be used for the drug discovery development.
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Key Words: antidiabetic, antioxidant, alloxan, glucose and T.grandis.
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