OXIDATIVE STRESS AND DIABETES: AN OVERVIEW
Abstract
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Oxidative stress is well known to be involved in the pathogenesis of lifestyle related diseases. Oxidative stress contributes to many pathological
conditions including cancer, asthma, atherosclerosis, hypertension, and diabetes. It is a state in which oxidation exceeds the antioxidant systems in the
body secondary to a loss of balance between them. Reactive oxygen species (ROS) are produced from molecular oxygen as a result of normal cellular
metabolism and environmental factors such as air pollutants, cigarette smoke and sedentary lifestyle. ROS are highly reactive molecules that can
damage carbohydrates, nucleic acids, lipids and proteins. There is considerable evidence that induction of oxidative stress is a key process in the onset
of diabetes. Lipid peroxidation owing to free radical activity plays an important role in complications of diabetes. Increased levels of lipid peroxidation
are a consequence of free radical activity in both Type 1 and Type 2 diabetes. The human body has several mechanisms to counter the effects of these
reactive species by the production of antioxidant enzymes like glutathione and catalase. Antioxidants can also be taken exogenously through the diet.
In this review article, we summarize the effect of oxidative stress in the development of diabetes.
Keywords: Diabetes, Oxidative stress, Lipid peroxidation, Reactive oxygen species.
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Haliwell B, Gutteridge JM. Free Radicles in Biology and Medicine. 3rd ed. New York: Oxford University Press; 1999.
Yeh HC, Platz EA, Wang NY, Visvanathan K, Helzlsouer KJ, Brancati FL. A prospective study of the associations between treated diabetes and cancer outcomes. Diabetes Care 2012;35(1):113-8.
Li D. Diabetes and pancreatic cancer. Mol Carcinog 2012;51(1):64-74.
Kashiwagi A. Complications of diabetes mellitus and oxidative stress. JMAJ 2001;44(12):521-8.
Lister J, Nash J, Ledingham U. Constitution and insulin sensitivity in diabetes mellitus. Br Med J 1951;1(4703):376-9.
Cudworth AG. The etiology of diabetis mellitus. Br J Hosp Med 1976;16:207-16.
Arora R, Vig AP, Arora S. Lipid peroxidation: A possible marker for diabetes. J Diabetes Metab 2013;S11:007.
Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001;345(11):790-7.
Zeyda M, Stulnig TM. Obesity, inflammation, and insulin resistence - A mini review. Gerontology 2009;55:379-86.
Chaput JP, Després JP, Bouchard C, Tremblay A. Association of sleep duration with type 2 diabetes and impaired glucose tolerance. Diabetologia 2007;50(11):2298-304.
Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J 2012;5(1):9-19.
Miller DM, Buettner GR, Aust SD. Transition metals as catalysts of autoxidation†reactions. Free Radic Biol Med 1990;8(1):95-108.
Dupuy C, Virion A, Ohayon R, Kaniewski J, Dème D, Pommier J. Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane. J Biol Chem 1991;266(6):
‑43.
Sen S, Chakraborty R, Sridhar C, Reddy YS, De B. Free radicals, antioxidants, diseases and phytomedicines: Current status and future prospect. Int J Pharm Sci Rev Res 2010;3(1):91-100.
Agarwal A, Gupta S. The Role of Free Radicals and Antioxidants in Female Infertility and Assisted Reproduction. UD Genito - Urinary Disease; 2006. p. 60-5.
Niki E. Lipid peroxidation: Physiological levels and dual biological effects. Free Radic Biol Med 2009;47(5):469-84.
Spiteller G. Are lipid peroxidation process induced by changes in the cell wall structure and how are these processes connected with diseases? Med Hypotheses 2003;60:69-83.
Donath MY, Størling J, Maedler K, Mandrup-Poulsen T. Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes. J Mol Med (Berl) 2003;81(8):455-70.
Pinkse GG, Tysma OH, Bergen CA, Kester MG, Ossendorp F, van Veelen PA, et al. Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A 2005;102:18425-30.
Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes care 2004;27:813-23.
Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003;112(12):1785-8.
Wiley J. Evaluation of some biochemical changes in diabetic patients. Diabetes Care 1992;15(10):413-22.
Akkus I, Kalak S, Vural H, Caglayan O, Menekse E, Can G, et al. Leukocyte lipid peroxidation, superoxide dismutase, glutathione peroxidase and serum and leukocyte vitamin C levels of patients with type II diabetes mellitus. Clin Chim Acta 1996;244(2):221-7.
Kalaivanam KN, Dharmalingam M, Marcus SR. Lipid peroxidation in type 2 diabetes. Int J Diabetes Dev Ctries 2006;26(1);30-2.
Niedowicz DM, Daleke DL. The role of oxidative stress in diabetic complications. Cell Biochem Biophys 2005;43(2):289-330.
Akbar S, Bellary S, Helen RG. A meta analysis. Br J Diabetes Vasc Dis 2011;11(2):62-8.
Basta G, Schmidt AM, De Caterina R. Advanced glycation end products and vascular inflammation: Implications for accelerated atherosclerosis in diabetes. Cardiovasc Res 2004;63(4):582-92.
Balu KC, Colin R, Gloria AB, Johnson MS, Darley-Usmar V. Chronic hyperglycaemia – Induced attenuation of mitochondrial reserve capacity mediates mesangial cell dysfunction in diabetes. Cent Free Radic Biol 2010;49:S36.
Jang YY, Song JH, Shin YK, Han ES, Lee CS. Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats. Pharmacol Res 2000;42(4):361-71.
Dalton TP, Shertzer HG, Puga A. Regulation of gene expression by reactive oxygen. Annu Rev Pharmacol Toxicol 1999;39:67-101.31. Dyer DG, Dunn JA, Thorpe SR, Bailie KE, Lyons TJ, McCance DR, et al. Accumulation of Maillard reaction products in skin collagen in diabetes and aging. J Clin Invest 1993;91(6):2463-9.
Ha H, Lee HB. Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose. Kidney Int Suppl 2000;77:S19-25.
Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414(6865):813-20.
Martin-Gallan P, Carrascosa A, Gussinye N, Dominguez C. Biomarkers of diabetes associated oxidative stress and antioxidative status in young diabetic patients with or without subclinical complications. Free Radic Biol Med 2003;34:1563-74.
Ceriello A. Oxidative stress and diabetes-associated complications. Endocr Pract 2006;12 Suppl 1:60-2.
Yung LM, Leung FP, Yao X, Chen ZY, Huang Y. Reactive oxygen species in vascular wall. Cardiovasc Hematol Disord Drug Targets 2006;6(1):1-19.
Niiya Y, Abumiya T, Shichinohe H, Kuroda S, Kikuchi S, Ieko M, et al. Susceptibility of brain microvascular endothelial cells to advanced glycation end products-induced tissue factor upregulation is associated with intracellular reactive oxygen species. Brain Res 2006;1108(1):179‑87.
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39(1):44-84.
Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci 2008;4(2):89-96.
Kojda G, Harrison D. Interactions between NO and reactive oxygen species: Pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res 1999;43:562‑71.
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