THE EFFECT OF PUGUNTANO (CURANGA FEL-TERRAE [LOUR.]) EXTRACT ON ADIPONECTIN RECEPTOR (ADIPOR) IN RATS WITH TYPE 2 DIABETES MELLITUS

DHARMA LINDARTO; YETTY MACHRINA; SANTI SYAFRIL; AWALUDDIN SARAGIH

doi:10.22159/ajpcr.2019.v12i2.30456

Authors

DHARMA LINDARTO Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.
YETTY MACHRINA Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.
SANTI SYAFRIL Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.
AWALUDDIN SARAGIH Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i2.30456

Keywords:

Type 2 diabetes mellitus, Puguntano, Adiponectin receptor

Abstract

Objective: This study aimed to determine whether the antidiabetic effects of puguntano (Curanga fel-terrae [Lour.]) extract involve anti-inflammatory effects mediated through adiponectin receptors (AdipoRs).

Methods: Type 2 diabetes mellitus (T2DM) Wistar rats were induced by a combination of high-fat diet for 5 weeks and injection small dose streptozotocin 30 mg/kg bw/rat. This study was conducted in 48 T2DM rats, which were randomly assigned into two weight-matched groups (n=24, each). Only the treatment group received 0.2 mg/g bw of puguntano extract suspension through oral for 10 days. The clinical characteristics of T2DM and AdipoR were assessed before and after the treatment period.

Results: The treatment group demonstrated significantly lower body weight, fasting blood glucose, and homeostasis model assessment-insulin resistance (HOMA-IR) but higher AdipoR than the control group (all, p<0.001). Furthermore, there were also negative correlations between AdipoR to body weight and HOMA-IR (all, p<0.05).

Conclusion: Our data suggest that puguntano could improve glucose metabolism and ameliorate insulin resistance and have anti-inflammatory effects mediated through AdipoR in T2DM.

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Author Biography

DHARMA LINDARTO, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.

Department of Internal Medicine, Division of endocrine-metabolic

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